EA201992076A1 - BETA-SECRETASE INHIBITORS - Google Patents
BETA-SECRETASE INHIBITORSInfo
- Publication number
- EA201992076A1 EA201992076A1 EA201992076A EA201992076A EA201992076A1 EA 201992076 A1 EA201992076 A1 EA 201992076A1 EA 201992076 A EA201992076 A EA 201992076A EA 201992076 A EA201992076 A EA 201992076A EA 201992076 A1 EA201992076 A1 EA 201992076A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- beta
- dementia
- compounds
- dementia associated
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Настоящее изобретение относится к трициклическим ингибиторам бета-секретазы, имеющим структуру, показанную в виде формул (I) и (II)и к их таутомерам и стереоизомерным формам, при этом радикалы определены в описании. Настоящее изобретение также относится к фармацевтическим композициям, содержащим такие соединения, к способам получения таких соединений и композиций и к применению таких соединений и композиций для предупреждения и лечения расстройств, в которые вовлечена бета-секретаза, таких как болезнь Альцгеймера (AD), умеренное когнитивное нарушение, угасание, деменция, деменция с тельцами Леви, синдром Дауна, деменция, ассоциированная с инсультом, деменция, ассоциированная с болезнью Паркинсона, деменция, ассоциированная с накоплением бета-амилоида, возрастная макулярная дегенерация, диабет 2 типа и другие нарушения обмена веществ.The present invention relates to tricyclic beta-secretase inhibitors having the structure shown in the form of formulas (I) and (II) and their tautomers and stereoisomeric forms, with radicals defined in the description. The present invention also relates to pharmaceutical compositions containing such compounds, to methods for producing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders involving beta-secretase, such as Alzheimer's disease (AD), mild cognitive impairment , extinction, dementia, dementia with Levi bodies, Down syndrome, dementia associated with stroke, dementia associated with Parkinson's disease, dementia associated with accumulation of beta-amyloid, age-related macular degeneration, type 2 diabetes and other metabolic disorders.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17189762 | 2017-09-07 | ||
PCT/EP2018/055401 WO2018162443A1 (en) | 2017-03-07 | 2018-03-06 | Inhibitors of beta secretase |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201992076A1 true EA201992076A1 (en) | 2020-03-19 |
Family
ID=59811157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201992076A EA201992076A1 (en) | 2017-09-07 | 2018-03-06 | BETA-SECRETASE INHIBITORS |
Country Status (2)
Country | Link |
---|---|
EA (1) | EA201992076A1 (en) |
WO (1) | WO2018162443A1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR077277A1 (en) * | 2009-07-09 | 2011-08-17 | Lilly Co Eli | BICYCLE COMPOUNDS (1,3) TIAZIN-2-AMINA PHARMACEUTICAL FORMULATION THAT INCLUDES IT AND ITS USE FOR THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
WO2011071109A1 (en) * | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | Fused heterocyclic compound having amino group |
WO2014059185A1 (en) * | 2012-10-12 | 2014-04-17 | Amgen Inc. | Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use |
-
2018
- 2018-03-06 WO PCT/EP2018/055401 patent/WO2018162443A1/en unknown
- 2018-03-06 EA EA201992076A patent/EA201992076A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2018162443A1 (en) | 2018-09-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201791367A1 (en) | 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE AND 3,4-DIHYDRO-2H-PIRROL-5-AMIN COMPOUNDS - BETA SECRETASE INHIBITORS | |
BR112017022568A2 (en) | compounds and their uses as bace1 inhibitors | |
EA201291366A1 (en) | DERIVATIVES 5-AMINO-3,6-DIHYDRO-1H-PYRAZIN-2-SHE AS BETA SECRETASE INHIBITORS (BACE) | |
NZ718728A (en) | Compound inhibiting activities of btk and/or jak3 kinases | |
EA201391296A1 (en) | DERIVATIVES 3,4-DIHYDROPYRROLO [1,2-a] PIRAZIN-1-ILAMINA, SUITABLE AS BETA SECRETASE INHIBITORS (BACE) | |
EA201391251A1 (en) | DERIVATIVES 6,7-DIHYDROPYRAZOLO [1,5-a] PIRAZIN-4-ILAMINA, SUITABLE AS BETA SECRETASE INHIBITORS (BACE) | |
EA201790817A1 (en) | 2-AMINO-3,5-DIFTOR-3,6-DIMETHYL-6-PHENYL-3,4,5,6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS FOR THE TREATMENT OF ALLZHEIMER'S DISEASE | |
UA109459C2 (en) | 5,6-Dihydroimidazo derivatives [1,2-a] Pyrazine-8-ylamine, Suitable as BACE-SECRETASE INHIBITORS (BACE) | |
EA201891067A1 (en) | [1,2,4] TRIAZOLO [1,5-a] PYRIMIDIN-7-ILY COMPOUND | |
JO3458B1 (en) | 2-Amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors | |
BR112012033291A2 (en) | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatment of alzheimer's disease and other forms of dementia | |
EA201491116A1 (en) | DERIVATIVES 6-DIFTORMETYL-5,6-DIGIDRO-2H- [1,4] OXAZIN-3-AMINE | |
MX2019004859A (en) | Combination treatments comprising administration of imidazopyrazinones. | |
EA201990400A1 (en) | COMPOUNDS AND COMPOSITIONS AND THEIR APPLICATION | |
EA201890449A1 (en) | FUMAGILLINUM HETEROCYCLIC COMPOUNDS AND METHODS FOR THEIR PRODUCTION AND APPLICATION | |
EA201592277A1 (en) | DERIVATIVES 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO [1,5-A] PYRAZINE AS BETA SECRETASE INHIBITORS | |
EA201790626A1 (en) | MACRO CYCLIC INHIBITORS LRRK2-KINASE | |
MX2020000523A (en) | Isochroman compounds and uses thereof. | |
MX2019006495A (en) | Treatment of neurological diseases. | |
EA201592307A1 (en) | DERIVATIVES 4-AMINO-6-PHENYL-6,7-DIHYDRO [1,2,3] TRIAZOLO [1,5-A] PIRAZINE AS BETA SECRETASE INHIBITORS (BACE) | |
EA201592278A1 (en) | DERIVATIVES 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO [1,5-A] PYRAZIN-3 (2H) -ON AS BETA SECRETASE INHIBITORS (BACE) | |
CR20220216A (en) | Heteroaryl-biphenyl amines for the treatment of pd-l1 diseases | |
CL2022001178A1 (en) | tyk2 pseudokinase ligands | |
PH12019500198A1 (en) | Compounds and compositions and uses thereof | |
EA201691788A1 (en) | HETEROAROMATIC COMPOUNDS AND THEIR APPLICATION AS DOPAMINE D1 LIGANDS |