EA201991977A1 - NEW CRYSTAL FORMS 1- (4 - {[6-AMINO-5- (4-PHENOXYPHENYL) PYRIMIDIN-4-ILAMINO] METHYL} PIPERIDIN-1-IL) PROPENONE - Google Patents

NEW CRYSTAL FORMS 1- (4 - {[6-AMINO-5- (4-PHENOXYPHENYL) PYRIMIDIN-4-ILAMINO] METHYL} PIPERIDIN-1-IL) PROPENONE

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Publication number
EA201991977A1
EA201991977A1 EA201991977A EA201991977A EA201991977A1 EA 201991977 A1 EA201991977 A1 EA 201991977A1 EA 201991977 A EA201991977 A EA 201991977A EA 201991977 A EA201991977 A EA 201991977A EA 201991977 A1 EA201991977 A1 EA 201991977A1
Authority
EA
Eurasian Patent Office
Prior art keywords
propenone
phenoxyphenyl
pyrimidin
piperidin
amino
Prior art date
Application number
EA201991977A
Other languages
Russian (ru)
Inventor
Аксель Беккер
Марко Пома
Эдоардо Бурини
Кристоф Заль
Ведад Тойеркорн
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Priority claimed from PCT/EP2018/054741 external-priority patent/WO2018154131A1/en
Publication of EA201991977A1 publication Critical patent/EA201991977A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к твердой форме 1-(4-{[6-амино-5-(4-феноксифенил)пиримидин-4-иламино]метил}пиперидин-1-ил)пропенона, или его фармацевтически приемлемым солям, применимым в качестве BTK ингибиторов.This invention relates to the solid form of 1- (4 - {[6-amino-5- (4-phenoxyphenyl) pyrimidin-4-ylamino] methyl} piperidin-1-yl) propenone, or its pharmaceutically acceptable salts, useful as BTK inhibitors.

EA201991977A 2017-07-03 2018-02-27 NEW CRYSTAL FORMS 1- (4 - {[6-AMINO-5- (4-PHENOXYPHENYL) PYRIMIDIN-4-ILAMINO] METHYL} PIPERIDIN-1-IL) PROPENONE EA201991977A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762528238P 2017-07-03 2017-07-03
PCT/EP2018/054741 WO2018154131A1 (en) 2017-02-27 2018-02-27 Novel crystalline forms of 1-(4-{[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-methyl}-piperidin-1-yl)-propenone

Publications (1)

Publication Number Publication Date
EA201991977A1 true EA201991977A1 (en) 2020-03-04

Family

ID=69942833

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201991977A EA201991977A1 (en) 2017-07-03 2018-02-27 NEW CRYSTAL FORMS 1- (4 - {[6-AMINO-5- (4-PHENOXYPHENYL) PYRIMIDIN-4-ILAMINO] METHYL} PIPERIDIN-1-IL) PROPENONE

Country Status (1)

Country Link
EA (1) EA201991977A1 (en)

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