EA201991517A1 - COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY - Google Patents

COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY

Info

Publication number
EA201991517A1
EA201991517A1 EA201991517A EA201991517A EA201991517A1 EA 201991517 A1 EA201991517 A1 EA 201991517A1 EA 201991517 A EA201991517 A EA 201991517A EA 201991517 A EA201991517 A EA 201991517A EA 201991517 A1 EA201991517 A1 EA 201991517A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
compositions
arginase activity
inhibiting arginase
compounds
Prior art date
Application number
EA201991517A
Other languages
Russian (ru)
Other versions
EA038517B1 (en
Inventor
Эрик Б. Сьорген
Джим Ли
Лицзин Чень
Роланд Дж. Бильдо
Тимоти Ф. Стэнтон
Майкл Ван Зандт
Даррен Уайтхауз
Гуннар Е. мл. Ягдманн
Лене Раункйер Петерсен
Франческо Парлати
Мэтью И. Гросс
Original Assignee
Калитера Байосайнсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Калитера Байосайнсиз, Инк. filed Critical Калитера Байосайнсиз, Инк.
Priority claimed from PCT/US2017/068307 external-priority patent/WO2018119440A1/en
Publication of EA201991517A1 publication Critical patent/EA201991517A1/en
Publication of EA038517B1 publication Critical patent/EA038517B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds

Abstract

Изобретение относится к новому классу соединений, которые проявляют ингибирующую активность в отношении аргиназы, и к фармацевтическим композициям, содержащим соединения по изобретению. Также обеспечиваются способы лечения рака с помощью ингибиторов аргиназы в соответствии с изобретением.The invention relates to a new class of compounds that exhibit arginase inhibitory activity and to pharmaceutical compositions containing the compounds of the invention. Also provided are methods for treating cancer with arginase inhibitors in accordance with the invention.

EA201991517A 2016-12-28 2017-12-22 Compositions and methods for inhibiting arginase activity EA038517B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662439614P 2016-12-28 2016-12-28
PCT/US2017/068307 WO2018119440A1 (en) 2016-12-22 2017-12-22 Compositions and methods for inhibiting arginase activity

Publications (2)

Publication Number Publication Date
EA201991517A1 true EA201991517A1 (en) 2019-12-30
EA038517B1 EA038517B1 (en) 2021-09-09

Family

ID=69061839

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201991517A EA038517B1 (en) 2016-12-28 2017-12-22 Compositions and methods for inhibiting arginase activity
EA202191495A EA202191495A1 (en) 2016-12-28 2017-12-22 COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202191495A EA202191495A1 (en) 2016-12-28 2017-12-22 COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY

Country Status (1)

Country Link
EA (2) EA038517B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012325909B2 (en) * 2011-10-20 2016-06-09 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators

Also Published As

Publication number Publication date
EA202191495A1 (en) 2021-09-13
EA038517B1 (en) 2021-09-09

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