EA201990689A1 - Бактериальные мини-клетки для доставки адъювантов на основе нуклеиновых кислот и способы их применения - Google Patents

Бактериальные мини-клетки для доставки адъювантов на основе нуклеиновых кислот и способы их применения

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Publication number
EA201990689A1
EA201990689A1 EA201990689A EA201990689A EA201990689A1 EA 201990689 A1 EA201990689 A1 EA 201990689A1 EA 201990689 A EA201990689 A EA 201990689A EA 201990689 A EA201990689 A EA 201990689A EA 201990689 A1 EA201990689 A1 EA 201990689A1
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Eurasian Patent Office
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adjuvents
ways
delivery
application
nucleic acids
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EA201990689A
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English (en)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1235—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Salmonella (G)
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
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  • Wood Science & Technology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Analytical Chemistry (AREA)
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Abstract

Настоящее изобретение относится к интактным мини-клеткам бактериального происхождения, содержащим адъюванты на основе нуклеиновых кислот или плазмиды, кодирующие адъюванты на основе нуклеиновых кислот, которые могут вызывать желаемый иммунный ответ в клетках-мишенях. Настоящее изобретение дополнительно относится к способам, где используются мини-клетки для доставки адъювантов на основе нуклеиновых кислот для применения при лечении заболеваний, включая неопластическое заболевание и рак.
EA201990689A 2016-10-06 2017-10-04 Бактериальные мини-клетки для доставки адъювантов на основе нуклеиновых кислот и способы их применения EA201990689A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662405074P 2016-10-06 2016-10-06
PCT/IB2017/056131 WO2018065923A1 (en) 2016-10-06 2017-10-04 Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same

Publications (1)

Publication Number Publication Date
EA201990689A1 true EA201990689A1 (ru) 2019-10-31

Family

ID=61829954

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201990689A EA201990689A1 (ru) 2016-10-06 2017-10-04 Бактериальные мини-клетки для доставки адъювантов на основе нуклеиновых кислот и способы их применения

Country Status (11)

Country Link
US (1) US11485976B2 (ru)
EP (1) EP3522935A4 (ru)
JP (2) JP7213798B2 (ru)
CN (1) CN110022905B (ru)
AU (1) AU2017339841A1 (ru)
CA (1) CA3039010A1 (ru)
EA (1) EA201990689A1 (ru)
IL (1) IL265855A (ru)
MA (1) MA46469A (ru)
SG (1) SG11201902940RA (ru)
WO (1) WO2018065923A1 (ru)

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SG11201702627UA (en) * 2014-10-03 2017-04-27 Engeneic Molecular Delivery Pty Ltd Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
CA3107095A1 (en) * 2018-07-23 2020-01-30 Engeneic Molecular Delivery Pty Ltd Compositions comprising bacterially derived minicells and methods of using the same

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WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
EP0970212A1 (en) 1997-03-19 2000-01-12 ZymoGenetics, Inc. Secreted salivary zsig32 polypeptides
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Also Published As

Publication number Publication date
WO2018065923A1 (en) 2018-04-12
US11485976B2 (en) 2022-11-01
US20180100159A1 (en) 2018-04-12
SG11201902940RA (en) 2019-05-30
AU2017339841A1 (en) 2019-05-02
IL265855A (en) 2019-06-30
JP7213798B2 (ja) 2023-01-27
CN110022905B (zh) 2024-02-06
JP2023022207A (ja) 2023-02-14
MA46469A (fr) 2019-08-14
CN110022905A (zh) 2019-07-16
TW201828994A (zh) 2018-08-16
JP2019533663A (ja) 2019-11-21
CA3039010A1 (en) 2018-04-12
EP3522935A4 (en) 2020-05-13
EP3522935A1 (en) 2019-08-14

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