EA201892724A1 - TETRAHYDROPYRIDO [3,4-b] INDOL MODELERS OF ESTROGEN RECEPTORS AND THEIR APPLICATION - Google Patents

TETRAHYDROPYRIDO [3,4-b] INDOL MODELERS OF ESTROGEN RECEPTORS AND THEIR APPLICATION

Info

Publication number
EA201892724A1
EA201892724A1 EA201892724A EA201892724A EA201892724A1 EA 201892724 A1 EA201892724 A1 EA 201892724A1 EA 201892724 A EA201892724 A EA 201892724A EA 201892724 A EA201892724 A EA 201892724A EA 201892724 A1 EA201892724 A1 EA 201892724A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetrahydropyrido
indol
modelers
estrogen receptors
application
Prior art date
Application number
EA201892724A
Other languages
Russian (ru)
Other versions
EA038835B1 (en
Inventor
Саймон Чарльз Гудакр
Шарада Лабади
Цзюнь Лян
Даниэль Фред Ортвайн
Николас Чарльз Рэй
Сяоцзин Ван
Джейсон Збиг
Бижун Чжан
Томми Лай
Цзянпэн Ляо
Чжиго Лю
Джон Вай
Тао Ван
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201892724A1 publication Critical patent/EA201892724A1/en
Publication of EA038835B1 publication Critical patent/EA038835B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В данном документе описаны соединения тетрагидропиридо[3,4-b]индол-1-ила с модулирующей активностью или функцией рецептора эстрогена, имеющие структуру формулы Iа также их стереоизомеры, таутомеры или фармацевтически приемлемые соли, и с заместителями и структурными особенностями, описанными в данном документе. Также описаны фармацевтические композиции и лекарственные препараты, которые включают соединения формулы I, а также способы применения таких модуляторов эстрогеновых рецепторов отдельно и в сочетании с другими терапевтическими агентами для лечения заболеваний или состояний, опосредованных или зависимых от эстрогеновых рецепторов.This document describes tetrahydropyrido [3,4-b] indol-1-yl compounds with modulating activity or estrogen receptor function, having a structure of formula Ia as well as their stereoisomers, tautomers or pharmaceutically acceptable salts, and with the substituents and structural features described in this document. Also described are pharmaceutical compositions and drugs that include compounds of formula I, as well as methods for using such estrogen receptor modulators separately and in combination with other therapeutic agents for treating diseases or conditions mediated or dependent on estrogen receptors.

EA201892724A 2015-04-02 2015-12-17 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF EA038835B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562142077P 2015-04-02 2015-04-02

Publications (2)

Publication Number Publication Date
EA201892724A1 true EA201892724A1 (en) 2019-04-30
EA038835B1 EA038835B1 (en) 2021-10-27

Family

ID=66436965

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201892724A EA038835B1 (en) 2015-04-02 2015-12-17 TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
EA202192092A EA202192092A3 (en) 2015-04-02 2015-12-17 TETRAHYDRO-PYRIDO[3,4-B]INDOL MODULATORS OF ESTROGEN RECEPTORS AND THEIR APPLICATION

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202192092A EA202192092A3 (en) 2015-04-02 2015-12-17 TETRAHYDRO-PYRIDO[3,4-B]INDOL MODULATORS OF ESTROGEN RECEPTORS AND THEIR APPLICATION

Country Status (1)

Country Link
EA (2) EA038835B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076352B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US20120202801A1 (en) * 2009-05-27 2012-08-09 Liangxian Cao Methods for treating breast cancer
CA2763485C (en) * 2009-05-27 2018-05-15 Neil Almstead Methods for treating cancer and non-neoplastic conditions
WO2010138695A1 (en) * 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating neurofibromatosis
SG11201403002RA (en) * 2011-12-14 2014-07-30 Seragon Pharmaceuticals Inc Fluorinated estrogen receptor modulators and uses thereof

Also Published As

Publication number Publication date
EA038835B1 (en) 2021-10-27
EA202192092A2 (en) 2021-11-30
EA202192092A3 (en) 2022-03-31

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