EA201892337A1 - ACTIVIN-LIKE RECEPTOR KINASE INHIBITORS - Google Patents

ACTIVIN-LIKE RECEPTOR KINASE INHIBITORS

Info

Publication number
EA201892337A1
EA201892337A1 EA201892337A EA201892337A EA201892337A1 EA 201892337 A1 EA201892337 A1 EA 201892337A1 EA 201892337 A EA201892337 A EA 201892337A EA 201892337 A EA201892337 A EA 201892337A EA 201892337 A1 EA201892337 A1 EA 201892337A1
Authority
EA
Eurasian Patent Office
Prior art keywords
activin
kinase inhibitors
receptor kinase
compounds
compositions
Prior art date
Application number
EA201892337A
Other languages
Russian (ru)
Inventor
Наташа Бройманс
Джейсон Д. Брубэйкер
Пол Е. Флеминг
Брайан Л. Ходаус
Джозеф Л. Ким
Джош Уэйтзиг
Бретт Уилльямс
Дуглас Уилсон
Кевин Дж. Уилсон
Original Assignee
Блюпринт Медсинс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Блюпринт Медсинс Корпорейшн filed Critical Блюпринт Медсинс Корпорейшн
Priority claimed from PCT/US2017/027775 external-priority patent/WO2017181117A1/en
Publication of EA201892337A1 publication Critical patent/EA201892337A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

В данном документе описаны соединения, которые ингибируют ALK2 и его мутантов, фармацевтические композиции, включая такие соединения, и способы применения таких соединений и композиций.This document describes compounds that inhibit ALK2 and its mutants, pharmaceutical compositions, including such compounds, and methods of using such compounds and compositions.

EA201892337A 2016-10-21 2017-04-14 ACTIVIN-LIKE RECEPTOR KINASE INHIBITORS EA201892337A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662411172P 2016-10-21 2016-10-21
PCT/US2017/027775 WO2017181117A1 (en) 2016-04-15 2017-04-14 Inhibitors of activin receptor-like kinase

Publications (1)

Publication Number Publication Date
EA201892337A1 true EA201892337A1 (en) 2020-01-09

Family

ID=69374457

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892337A EA201892337A1 (en) 2016-10-21 2017-04-14 ACTIVIN-LIKE RECEPTOR KINASE INHIBITORS

Country Status (1)

Country Link
EA (1) EA201892337A1 (en)

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