EA201892327A1 - Ингаляционные и назальные бензодиазепины - Google Patents
Ингаляционные и назальные бензодиазепиныInfo
- Publication number
- EA201892327A1 EA201892327A1 EA201892327A EA201892327A EA201892327A1 EA 201892327 A1 EA201892327 A1 EA 201892327A1 EA 201892327 A EA201892327 A EA 201892327A EA 201892327 A EA201892327 A EA 201892327A EA 201892327 A1 EA201892327 A1 EA 201892327A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- benzodiazepina
- nazal
- inhalation
- remiamazolam
- oindp
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Anesthesiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к ингаляционному и назальному лекарственному продукту (OINDP), содержащему бензодиазепин, в частности ремимазолам.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU93027 | 2016-04-14 | ||
PCT/EP2017/059214 WO2017178663A1 (en) | 2016-04-14 | 2017-04-18 | Orally inhaled and nasal benzodiazepines |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201892327A1 true EA201892327A1 (ru) | 2019-04-30 |
EA036520B1 EA036520B1 (ru) | 2020-11-19 |
Family
ID=55949007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892327A EA036520B1 (ru) | 2016-04-14 | 2017-04-18 | Ингаляционные и назальные бензодиазепины |
Country Status (12)
Country | Link |
---|---|
US (3) | US20190175613A1 (ru) |
EP (1) | EP3442539A1 (ru) |
JP (2) | JP2019513796A (ru) |
KR (1) | KR20180131617A (ru) |
CN (1) | CN109641000A (ru) |
AU (1) | AU2017248683A1 (ru) |
BR (1) | BR112018071082A2 (ru) |
CA (1) | CA3020722A1 (ru) |
EA (1) | EA036520B1 (ru) |
IL (1) | IL262087B (ru) |
MX (1) | MX2018012498A (ru) |
WO (1) | WO2017178663A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111346098B (zh) * | 2018-12-21 | 2022-05-27 | 宜昌人福药业有限责任公司 | 苯二氮䓬类化合物局部用药物组合物及制备方法和用途 |
CN111346058B (zh) * | 2018-12-21 | 2022-05-17 | 宜昌人福药业有限责任公司 | 一种苯二氮䓬类化合物经鼻粘膜给药的药物组合物及其制备方法和用途 |
CN111346065B (zh) * | 2018-12-21 | 2022-05-20 | 宜昌人福药业有限责任公司 | 苯二氮䓬类化合物口腔用固体药物组合物及其制备方法 |
EP3714884A1 (en) | 2019-03-27 | 2020-09-30 | Paion UK Limited | Medical uses for benzodiazepines with a particular eeg pattern |
CN112209932B (zh) * | 2019-07-12 | 2023-03-24 | 成都倍特药业股份有限公司 | 一种化合物氢溴酸盐的新固体形态及其制备方法和用途 |
CN112462015B (zh) * | 2020-11-18 | 2022-07-12 | 海南倍特药业有限公司 | 一种氢溴酸瑞马***细菌内毒素的检测方法 |
CN112402428B (zh) * | 2020-11-26 | 2022-02-25 | 李依泽 | 瑞马***在制备治疗阿片类药物诱发的术后痛觉过敏的药物中的应用 |
CN114588164B (zh) * | 2022-04-19 | 2023-08-11 | 天津医科大学总医院 | 瑞马***在预防围术期低体温和寒战中的应用 |
WO2024126745A1 (en) * | 2022-12-16 | 2024-06-20 | Lts Lohmann Therapie-Systeme Ag | Oromucosal delivery system containing remimazolam |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4950664A (en) * | 1988-09-16 | 1990-08-21 | Rugby-Darby Group Companies, Inc. | Nasal administration of benzodiazepine hypnotics |
CA2143246C (en) | 1994-03-16 | 2000-08-22 | Thierry Godel | Imidazodiazepines |
US6174881B1 (en) | 1995-01-06 | 2001-01-16 | Hoffman-La Roche Inc. | Hydroxymethylimidazodiazepines and their esters |
WO1996023790A1 (de) | 1995-02-02 | 1996-08-08 | F. Hoffmann-La Roche Ag | Acetylimidazobenzodiazepine |
GB9911152D0 (en) | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
US7160880B1 (en) * | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
KR20090045233A (ko) * | 2006-07-10 | 2009-05-07 | 파이온 유케이 리미티드 | 속효형 벤조디아제핀 염 및 이의 중합체 형태 |
GB0613693D0 (en) | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
GB0613692D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts |
GB0716907D0 (en) * | 2007-08-31 | 2007-10-10 | Archimedes Dev Ltd | Pharmaceutical powder compositions |
EP2305647A1 (en) * | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
EP2450039A1 (en) * | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
WO2012075286A2 (en) * | 2010-12-01 | 2012-06-07 | The Regents Of The University Of California | Intrapulmonary benzodiazepine for the treatment and prevention of seizures |
EP2694076A4 (en) * | 2011-04-01 | 2014-08-27 | Cpex Pharmaceuticals Inc | NASAL FORMULATIONS FROM BENZODIAZEPINE |
CN102964349A (zh) | 2011-08-31 | 2013-03-13 | 江苏恒瑞医药股份有限公司 | 苯并二氮杂*衍生物的托西酸盐及其多晶型、它们的制备方法和用途 |
CN104968348B (zh) | 2012-05-22 | 2018-04-17 | Paion英国有限公司 | 包含短效苯二氮杂*类化合物的组合物 |
JP6199869B2 (ja) * | 2012-08-31 | 2017-09-20 | パイオン ユーケー リミティド | 催眠鎮静剤の投与方式 |
AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
CN103232454A (zh) * | 2013-05-05 | 2013-08-07 | 王元青 | 治疗精神疾病的药物 |
CN107198691A (zh) * | 2016-03-17 | 2017-09-26 | 江苏恒瑞医药股份有限公司 | 一种瑞马***的药物组合物 |
-
2017
- 2017-04-18 BR BR112018071082A patent/BR112018071082A2/pt not_active Application Discontinuation
- 2017-04-18 EA EA201892327A patent/EA036520B1/ru unknown
- 2017-04-18 EP EP17721067.1A patent/EP3442539A1/en active Pending
- 2017-04-18 MX MX2018012498A patent/MX2018012498A/es unknown
- 2017-04-18 CN CN201780032691.5A patent/CN109641000A/zh active Pending
- 2017-04-18 JP JP2018554457A patent/JP2019513796A/ja not_active Ceased
- 2017-04-18 US US16/093,112 patent/US20190175613A1/en not_active Abandoned
- 2017-04-18 AU AU2017248683A patent/AU2017248683A1/en not_active Abandoned
- 2017-04-18 KR KR1020187032827A patent/KR20180131617A/ko active IP Right Grant
- 2017-04-18 CA CA3020722A patent/CA3020722A1/en not_active Abandoned
- 2017-04-18 WO PCT/EP2017/059214 patent/WO2017178663A1/en active Application Filing
-
2018
- 2018-10-03 IL IL262087A patent/IL262087B/en unknown
-
2020
- 2020-03-24 US US16/828,719 patent/US20200253983A1/en not_active Abandoned
-
2021
- 2021-08-20 JP JP2021134968A patent/JP2021185170A/ja not_active Withdrawn
-
2022
- 2022-01-06 US US17/569,887 patent/US20220273672A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220273672A1 (en) | 2022-09-01 |
WO2017178663A1 (en) | 2017-10-19 |
BR112018071082A2 (pt) | 2019-02-05 |
AU2017248683A1 (en) | 2018-10-25 |
MX2018012498A (es) | 2019-07-01 |
EA036520B1 (ru) | 2020-11-19 |
CA3020722A1 (en) | 2017-10-19 |
US20190175613A1 (en) | 2019-06-13 |
JP2019513796A (ja) | 2019-05-30 |
IL262087B (en) | 2021-09-30 |
KR20180131617A (ko) | 2018-12-10 |
IL262087A (en) | 2018-11-29 |
EP3442539A1 (en) | 2019-02-20 |
US20200253983A1 (en) | 2020-08-13 |
CN109641000A (zh) | 2019-04-16 |
JP2021185170A (ja) | 2021-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201892327A1 (ru) | Ингаляционные и назальные бензодиазепины | |
CY1124729T1 (el) | Φαρμακοτεχνικες μορφες του ενζαλουταμιδιου | |
MX2022001755A (es) | Compuestos de dinucleotidos ciclicos y metodos de uso. | |
HK1246103A1 (zh) | 非燃燒型香味抽吸器、香吸味源單元及霧化單元 | |
MX2020009649A (es) | Anticuerpos monoclonales contra bcma. | |
EA202091615A1 (ru) | Интраназальные составы на основе эпинефрина и способы лечения заболевания | |
BR112018012145A2 (pt) | partículas de entrega de pró-sabor | |
EA201891791A1 (ru) | Надежно прикрепляющиеся картриджи для испарительных устройств | |
MX2017004838A (es) | Composiciones de interleucina-15 y usos de estas. | |
MY187540A (en) | Compounds active towards bromodomains | |
MY184586A (en) | Adenoassociated virus vectors for the treatment of mucopolysaccharidoses | |
UA116648C2 (uk) | Фумарати як проліки та їх застосування при лікуванні різних захворювань | |
PH12016502248A1 (en) | Adenoassociated virus vectors for the treatment of lysosomal storage disorders | |
EA201790575A1 (ru) | Триазолопиразиноны в качестве ингибиторов pde1 | |
MX2018007304A (es) | Composiciones de interleucina-15 y sus usos. | |
EA201792157A1 (ru) | Имидазопиразиноны в качестве ингибиторов pde1 | |
EA202090683A3 (ru) | Способы и композиции для лечения рака | |
PH12019501018A1 (en) | Pharmaceutical composition, methods for treating and uses thereof | |
TR201910866T4 (tr) | Kanser tedavisi için birleşik preparasyonlar. | |
EA033510B1 (ru) | Содержащая цинеол композиция для назального применения | |
MX2017012596A (es) | Una composicion farmaceutica y el uso de la misma. | |
CO2017001601A2 (es) | Derivados de 1-acetil-4-((pirazin-2-il) amino)-1,2,3,4-tetrahydroquinolina-6 carboxamida como inhibidores de bromodominio | |
EA201792571A1 (ru) | Терапевтическое применение l-4-хлорокинуренина | |
SG10201805646WA (en) | Angiopoietin-like 4 antibodies and methods of use | |
MX2018005358A (es) | Comprimido de dosis alta que contiene mesalazina optimizado. |