EA201890390A8 - БИСПЕЦИФИЧЕСКИЕ КОНСТРУКТЫ АНТИТЕЛ, СВЯЗЫВАЮЩИЕ EGFRvIII И CD3 - Google Patents

БИСПЕЦИФИЧЕСКИЕ КОНСТРУКТЫ АНТИТЕЛ, СВЯЗЫВАЮЩИЕ EGFRvIII И CD3

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Publication number
EA201890390A8
EA201890390A8 EA201890390A EA201890390A EA201890390A8 EA 201890390 A8 EA201890390 A8 EA 201890390A8 EA 201890390 A EA201890390 A EA 201890390A EA 201890390 A EA201890390 A EA 201890390A EA 201890390 A8 EA201890390 A8 EA 201890390A8
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EA
Eurasian Patent Office
Prior art keywords
antibody construct
present
specific antibody
antibody structures
egfrviii
Prior art date
Application number
EA201890390A
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English (en)
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EA039859B1 (ru
EA201890390A1 (ru
Inventor
Тобиас РАУМ
Петер КУФЕР
Дорис РАУ
Маркус Мюнц
Инес Херрманн
Патрик ХОФФМАНН
Йоханнес Брози
Маттиас Фридрих
Бенно Раттель
Памела Богнер
Андреас Вольф
Корнелиус Помпе
Original Assignee
Эмджен Рисерч (Мюник) Гмбх
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Application filed by Эмджен Рисерч (Мюник) Гмбх filed Critical Эмджен Рисерч (Мюник) Гмбх
Priority claimed from PCT/EP2016/068332 external-priority patent/WO2017021370A1/en
Publication of EA201890390A1 publication Critical patent/EA201890390A1/ru
Publication of EA201890390A8 publication Critical patent/EA201890390A8/ru
Publication of EA039859B1 publication Critical patent/EA039859B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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Abstract

Настоящее изобретение относится к биспецифическому конструкту антитела, содержащему первый связывающий домен, связывающийся с EGFRvIII человека на поверхности клетки-мишени, и второй связывающий домен, связывающийся с CD3 человека на поверхности T-клетки. Кроме того, в настоящем изобретении предложены полинуклеотид, кодирующий конструкт антитела, вектор, содержащий указанный полинуклеотид, и клетка-хозяин, трансформированная или трансфицированная указанным полинуклеотидом или вектором. Кроме того, в настоящем изобретении предложены способ получения конструкта антитела согласно настоящему изобретению, медицинское применение указанного конструкта антитела и набор, содержащий указанный конструкт антитела.
EA201890390A 2016-02-03 2016-08-01 Биспецифические конструкты антител, связывающие egfrviii и cd3 EA039859B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662290861P 2016-02-03 2016-02-03
PCT/EP2016/068332 WO2017021370A1 (en) 2015-07-31 2016-08-01 Bispecific antibody constructs binding egfrviii and cd3

Publications (3)

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EA201890390A1 EA201890390A1 (ru) 2018-06-29
EA201890390A8 true EA201890390A8 (ru) 2019-09-30
EA039859B1 EA039859B1 (ru) 2022-03-21

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EA201890390A EA039859B1 (ru) 2016-02-03 2016-08-01 Биспецифические конструкты антител, связывающие egfrviii и cd3
EA201891749A EA201891749A1 (ru) 2016-02-03 2017-02-02 Биспецифические конструкции антител, вовлекающие т-клетки

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US (2) US11434302B2 (ru)
EP (1) EP3411403A1 (ru)
JP (2) JP7016217B2 (ru)
KR (1) KR20180104137A (ru)
CN (1) CN109071662A (ru)
AR (1) AR107520A1 (ru)
AU (1) AU2017214251B2 (ru)
BR (1) BR112018015670A2 (ru)
CA (1) CA3010685A1 (ru)
CL (3) CL2018002046A1 (ru)
CO (1) CO2018009112A2 (ru)
CR (1) CR20180417A (ru)
EA (2) EA039859B1 (ru)
HK (1) HK1257748A1 (ru)
IL (2) IL306066A (ru)
JO (2) JOP20170028B1 (ru)
MA (1) MA43956A (ru)
MX (1) MX2018009383A (ru)
MY (1) MY192682A (ru)
PE (2) PE20230995A1 (ru)
PH (1) PH12018501548A1 (ru)
SG (2) SG10202007213QA (ru)
TN (1) TN2018000265A1 (ru)
TW (2) TWI754628B (ru)
UA (1) UA126280C2 (ru)
UY (1) UY37104A (ru)
WO (1) WO2017134140A1 (ru)
ZA (1) ZA201804514B (ru)

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