EA201792642A1 - Способы диагностики для т-клеточной терапии - Google Patents

Способы диагностики для т-клеточной терапии

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Publication number
EA201792642A1
EA201792642A1 EA201792642A EA201792642A EA201792642A1 EA 201792642 A1 EA201792642 A1 EA 201792642A1 EA 201792642 A EA201792642 A EA 201792642A EA 201792642 A EA201792642 A EA 201792642A EA 201792642 A1 EA201792642 A1 EA 201792642A1
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EA
Eurasian Patent Office
Prior art keywords
cell therapy
patient
diagnostic methods
physiological adaptation
introduction
Prior art date
Application number
EA201792642A
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English (en)
Inventor
Эдриан Бот
Джеффри С. Вьезорек
Уилльям Го
Раджул Джаин
Джеймс Н. Кохендерфер
Стивен А. Розенберг
Original Assignee
Кайт Фарма, Инк.
Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57393492&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201792642(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Кайт Фарма, Инк., Дзе Юнайтед Стейтс Оф Эмерика, Эз Репрезентед Бай Дзе Секретэри, Дипартмент Оф Хелт Энд Хьюман Сервисиз filed Critical Кайт Фарма, Инк.
Publication of EA201792642A1 publication Critical patent/EA201792642A1/ru

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Abstract

Изобретение предоставляет способы повышения эффективности T-клеточной терапии для нуждающегося в ней пациента. Изобретение включает в себя способы идентификации пациента, который хорошо отвечал бы на T-клеточную терапию, или физиологическую адаптацию пациента до T-клеточной терапии таким образом, чтобы пациент хорошо отвечал на T-клеточную терапию. Физиологическая адаптация включает в себя введение одного или более средств предварительной физиологической адаптации до T-клеточной терапии и идентификацию цитокинов-биомаркеров до введения T-клеточной терапии.
EA201792642A 2015-05-28 2016-05-27 Способы диагностики для т-клеточной терапии EA201792642A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562167738P 2015-05-28 2015-05-28
US201562262111P 2015-12-02 2015-12-02
PCT/US2016/034885 WO2016191755A1 (en) 2015-05-28 2016-05-27 Diagnostic methods for t cell therapy

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EA201792642A1 true EA201792642A1 (ru) 2018-10-31

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US (2) US11779601B2 (ru)
EP (2) EP3302507B1 (ru)
JP (3) JP6917903B2 (ru)
KR (3) KR20230005428A (ru)
CN (2) CN107921064A (ru)
AU (2) AU2016268863B2 (ru)
BR (1) BR122023022076A2 (ru)
CA (1) CA2986793A1 (ru)
CL (1) CL2017003005A1 (ru)
DO (1) DOP2017000272A (ru)
EA (1) EA201792642A1 (ru)
ES (1) ES2944962T3 (ru)
HK (2) HK1246150A1 (ru)
IL (2) IL255888B2 (ru)
MA (1) MA45281A (ru)
MX (2) MX2017015190A (ru)
PH (1) PH12017502153A1 (ru)
PL (1) PL3302507T3 (ru)
PT (1) PT3302507T (ru)
SG (2) SG10201913620QA (ru)
SI (1) SI3302507T1 (ru)
WO (1) WO2016191755A1 (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014117121A1 (en) 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
PT3143134T (pt) 2014-05-15 2020-12-04 Nat Univ Singapore Células assassinas naturais modificadas e seus usos
CN107921066A (zh) 2015-05-28 2018-04-17 凯德药业股份有限公司 为t细胞疗法而调理患者的方法
CA2986793A1 (en) 2015-05-28 2016-12-01 Kite Pharma, Inc. Diagnostic methods for t cell therapy
KR102624509B1 (ko) 2017-03-27 2024-01-12 싱가포르국립대학교 자연 살해 세포의 ex vivo 확장 및 활성화를 위한 자극성 세포주
US11365236B2 (en) 2017-03-27 2022-06-21 Nkarta, Inc. Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy
KR20220144888A (ko) 2017-04-03 2022-10-27 카이트 파마 인코포레이티드 최적화된 다기능 t 세포를 포함하는 키메라 수용체 t 세포를 사용하는 치료
MX2019014268A (es) 2017-06-02 2020-08-03 Juno Therapeutics Inc Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva.
WO2019207942A1 (ja) * 2018-04-27 2019-10-31 OTA Takayo 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー
SG11202011541SA (en) * 2018-06-01 2020-12-30 Kite Pharma Inc Chimeric antigen receptor t cell therapy
US20210155941A1 (en) 2018-06-22 2021-05-27 Kite Pharma Eu B.V. Compositions and methods for making engineered t cells
CN109207430A (zh) * 2018-09-25 2019-01-15 华东师范大学 一种嵌合抗原受体nk细胞及其制备方法和应用
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
JP2023513434A (ja) * 2020-01-24 2023-03-31 ジュノー セラピューティクス インコーポレイテッド 養子細胞療法における投与ならびに濾胞性リンパ腫および辺縁帯リンパ腫の処置のための方法
IL297594A (en) 2020-04-28 2022-12-01 Achilles Therapeutics Uk Ltd t cell therapy
JP2023552773A (ja) * 2020-12-04 2023-12-19 セルジーン コーポレーション 炎症関連可溶性因子の阻害剤と組み合わせたキメラ抗原受容体（ｃａｒ）ｔ細胞療法の使用
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
EP4320435A1 (en) 2021-04-09 2024-02-14 Achilles Therapeutics UK Limited Batch release assay for pharmaceutical products relating to t cell therapies
IL309200A (en) 2021-06-22 2024-02-01 Achilles Therapeutics Uk Ltd A method for producing antigen-specific T cells
US20230392119A1 (en) 2022-05-27 2023-12-07 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
WO2024092227A1 (en) 2022-10-28 2024-05-02 Kite Pharma, Inc. Factors for optimizing immunotherapy
WO2024092145A1 (en) 2022-10-28 2024-05-02 Kite Pharma, Inc. Expedited administration of engineered lymphocytes

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US20030031652A1 (en) 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
US7718196B2 (en) 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
DK1545204T3 (en) 2002-09-06 2016-11-14 The Government Of The Us Secretary Dept Of Health And Human Services Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
KR20180108886A (ko) 2010-03-23 2018-10-04 인트렉손 코포레이션 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도
AU2011338200B2 (en) 2010-12-09 2017-02-23 The Trustees Of The University Of Pennsylvania Use of chimeric antigen receptor-modified T cells to treat cancer
AU2012207356A1 (en) 2011-01-18 2013-08-01 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
MX2014003176A (es) 2011-09-16 2015-08-05 Univ Pennsylvania Celulas t diseñadas mediante arn para el tratamiento de cancer.
US9931359B2 (en) 2012-05-08 2018-04-03 The Johns Hopkins University Methods and compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes to treat cancer
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014204762A1 (en) 2013-06-19 2014-12-24 Massachusetts Institute Of Technology In vivo targeting of cells with ligand-conjugated particles
AU2014346852A1 (en) 2013-11-05 2016-06-16 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
CA2986793A1 (en) 2015-05-28 2016-12-01 Kite Pharma, Inc. Diagnostic methods for t cell therapy
CN107921066A (zh) * 2015-05-28 2018-04-17 凯德药业股份有限公司 为t细胞疗法而调理患者的方法
AU2017240667C1 (en) 2016-04-01 2022-11-24 Kite Pharma, Inc. Chimeric antigen and T cell receptors and methods of use

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