EA201792394A2 - Derivatives of 2- (2,4,5-substituted-anilino) pyrimidine as modulators of EGFR, useful for the treatment of cancer - Google Patents
Derivatives of 2- (2,4,5-substituted-anilino) pyrimidine as modulators of EGFR, useful for the treatment of cancerInfo
- Publication number
- EA201792394A2 EA201792394A2 EA201792394A EA201792394A EA201792394A2 EA 201792394 A2 EA201792394 A2 EA 201792394A2 EA 201792394 A EA201792394 A EA 201792394A EA 201792394 A EA201792394 A EA 201792394A EA 201792394 A2 EA201792394 A2 EA 201792394A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- useful
- salts
- egfr
- pyrimidine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Настоящее изобретение относится к некоторым 2-(2,4,5-замещенным анилино)пиримидиновым соединениям и их фармацевтически приемлемым солям, которые могут быть полезны в лечении или предупреждении заболевания или медицинского состояния, опосредованного некоторыми мутированными формами рецептора эпидермального фактора роста (например, L858R активирующий мутант, активирующий мутант с делецией в экзоне 19 и Т790М резистентный мутант). Такие соединения и их соли могут быть полезны в лечении или предупреждении ряда различных злокачественных новообразований. Изобретение также относится к фармацевтическим композициям, содержащим указанные соединения и их соли, особенно полезным полиморфным формам этих соединений и солей, промежуточным соединениям, полезным в получении указанных соединений, и к способам лечения заболеваний, опосредованных разнообразными различными формами EGFR, с использованием указанных соединений и их солей.The present invention relates to certain 2- (2,4,5-substituted anilino) pyrimidine compounds and their pharmaceutically acceptable salts, which may be useful in treating or preventing a disease or medical condition mediated by certain mutated forms of the epidermal growth factor receptor (for example, L858R activating mutant, activating deletion mutant in exon 19 and T790M resistant mutant). Such compounds and their salts may be useful in treating or preventing a number of different malignant neoplasms. The invention also relates to pharmaceutical compositions containing said compounds and their salts, particularly useful polymorphic forms of these compounds and salts, intermediate compounds useful in preparing said compounds, and methods for treating diseases mediated by various different forms of EGFR using these compounds and their salts.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201161512061P | 2011-07-27 | 2011-07-27 | |
US201261591363P | 2012-01-27 | 2012-01-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201792394A2 true EA201792394A2 (en) | 2018-03-30 |
EA201792394A3 EA201792394A3 (en) | 2018-07-31 |
EA033733B1 EA033733B1 (en) | 2019-11-20 |
Family
ID=46875901
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690328A EA029488B1 (en) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer |
EA201792394A EA033733B1 (en) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer and intermediates for manufacture thereof |
EA201391491A EA024421B1 (en) | 2011-07-27 | 2012-07-25 | N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide and pharmaceutically acceptable salts thereof as egfr modulators useful for treating cancer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690328A EA029488B1 (en) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-substituted-anilino)pyrimidine derivatives as egfr modulators useful for treating cancer |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201391491A EA024421B1 (en) | 2011-07-27 | 2012-07-25 | N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide and pharmaceutically acceptable salts thereof as egfr modulators useful for treating cancer |
Country Status (39)
Country | Link |
---|---|
US (6) | US8946235B2 (en) |
EP (7) | EP3009431B1 (en) |
JP (3) | JP5427321B2 (en) |
KR (3) | KR101691268B1 (en) |
CN (7) | CN105348266B (en) |
AR (1) | AR087336A1 (en) |
AU (1) | AU2012288626C1 (en) |
BR (4) | BR122014026094B1 (en) |
CA (5) | CA2881993C (en) |
CL (1) | CL2013003281A1 (en) |
CO (1) | CO6811863A2 (en) |
CR (1) | CR20130629A (en) |
CY (4) | CY1117431T1 (en) |
DK (5) | DK3333161T3 (en) |
DO (1) | DOP2013000263A (en) |
EA (3) | EA029488B1 (en) |
EC (1) | ECSP13013033A (en) |
ES (5) | ES2914854T3 (en) |
GT (1) | GT201300288A (en) |
HK (4) | HK1192549A1 (en) |
HR (4) | HRP20211682T1 (en) |
HU (4) | HUE026429T2 (en) |
IL (6) | IL229199A (en) |
LT (3) | LT3333161T (en) |
ME (3) | ME02887B (en) |
MX (2) | MX2014000528A (en) |
MY (2) | MY161925A (en) |
NI (1) | NI201300134A (en) |
PE (1) | PE20141700A1 (en) |
PH (1) | PH12015501326B1 (en) |
PL (5) | PL3009431T3 (en) |
PT (4) | PT3686193T (en) |
RS (4) | RS54653B1 (en) |
SG (5) | SG10201910986QA (en) |
SI (4) | SI3333161T1 (en) |
SM (1) | SMT201600070B (en) |
TW (3) | TWI465445B (en) |
UY (1) | UY34219A (en) |
WO (1) | WO2013014448A1 (en) |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2702631C2 (en) * | 2014-10-11 | 2019-10-09 | Шанхай Хэнсох Биомедикал Ко., Лтд. | Inhibitor of egfr and production and use thereof |
RU2734849C2 (en) * | 2015-07-16 | 2020-10-23 | Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. | Aniline pyrimidine derivatives and use thereof |
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