EA201791918A1 - MODIFICATION OF PROTEINS OF CELL-OWNERS - Google Patents
MODIFICATION OF PROTEINS OF CELL-OWNERSInfo
- Publication number
- EA201791918A1 EA201791918A1 EA201791918A EA201791918A EA201791918A1 EA 201791918 A1 EA201791918 A1 EA 201791918A1 EA 201791918 A EA201791918 A EA 201791918A EA 201791918 A EA201791918 A EA 201791918A EA 201791918 A1 EA201791918 A1 EA 201791918A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- proteins
- owners
- modification
- cell
- proposed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
Abstract
Предлагаются композиции и способы для сконструированных клеточных линий и экспрессионных систем, которые позволяют экспрессировать рекомбинантные белки в эукариотических клетках и облегчают их выделение. Также предлагаются клеточные экспрессирующие системы, способные экспрессировать белок, представляющий интерес, по существу, свободный от связанного белка клетки-хозяина.Compositions and methods for engineered cell lines and expression systems are proposed that allow the expression of recombinant proteins in eukaryotic cells and facilitate their isolation. Cellular expression systems are also proposed that are capable of expressing a protein of interest substantially free of the associated host cell protein.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562126213P | 2015-02-27 | 2015-02-27 | |
US201662298869P | 2016-02-23 | 2016-02-23 | |
PCT/US2016/019915 WO2016138467A1 (en) | 2015-02-27 | 2016-02-26 | Host cell protein modification |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201791918A1 true EA201791918A1 (en) | 2017-12-29 |
Family
ID=55538620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791918A EA201791918A1 (en) | 2015-02-27 | 2016-02-26 | MODIFICATION OF PROTEINS OF CELL-OWNERS |
Country Status (20)
Country | Link |
---|---|
US (1) | US20160251411A1 (en) |
EP (1) | EP3262168B1 (en) |
JP (1) | JP6751402B2 (en) |
KR (1) | KR20170120126A (en) |
CN (1) | CN107406831A (en) |
AU (1) | AU2016224988A1 (en) |
BR (1) | BR112017018149A2 (en) |
CA (1) | CA2976669A1 (en) |
DK (1) | DK3262168T3 (en) |
EA (1) | EA201791918A1 (en) |
ES (1) | ES2751670T3 (en) |
HK (1) | HK1248272A1 (en) |
HU (1) | HUE045862T2 (en) |
IL (1) | IL253863A0 (en) |
MX (1) | MX2017011012A (en) |
MY (1) | MY180896A (en) |
SG (1) | SG11201706335TA (en) |
TW (1) | TW201702380A (en) |
WO (1) | WO2016138467A1 (en) |
ZA (1) | ZA201705712B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018039499A1 (en) * | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
CN116327963A (en) | 2016-11-21 | 2023-06-27 | 济世-伊沃泰克生物制品有限公司 | Ophthalmic preparation and application thereof |
CA3067735A1 (en) | 2017-08-17 | 2019-02-21 | Just Biotherapeutics, Inc. | Method of purifying glycosylated protein from host cell galectins and other contaminants |
JP2021521873A (en) * | 2018-05-04 | 2021-08-30 | シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co. LLC | Manipulated cells with modified host cell protein profile |
SG11202009499VA (en) * | 2018-05-04 | 2020-11-27 | Sigma Aldrich Co Llc | Producing recombinant proteins with reduced levels of host cell proteins |
EP4028542A1 (en) * | 2019-09-12 | 2022-07-20 | Lonza Ltd. | Compositions, methods, and kits for detection of lipolytic activity |
KR20220054689A (en) | 2019-10-15 | 2022-05-03 | 일라이 릴리 앤드 캄파니 | Recombinantly engineered, lipase/esterase-deficient mammalian cell line |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2256895T3 (en) * | 1996-09-19 | 2006-07-16 | Novozymes A/S | GUEST CELLS AND PROTEIN PRODUCTION METHODS. |
ES2522615T3 (en) | 2007-06-04 | 2014-11-17 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
GB201000587D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
AU2012290379A1 (en) * | 2011-07-29 | 2014-02-06 | Eleven Biotherapeutics, Inc. | Purified proteins |
US8697359B1 (en) * | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
CN105722532A (en) | 2013-09-13 | 2016-06-29 | 豪夫迈·罗氏有限公司 | Methods and compositions comprising purified recombinant polypeptides |
KR102332302B1 (en) * | 2013-09-13 | 2021-12-01 | 제넨테크, 인크. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
US9932591B2 (en) * | 2013-12-18 | 2018-04-03 | University Of Delaware | Reduction of lipase activity in product formulations |
-
2016
- 2016-02-25 TW TW105105690A patent/TW201702380A/en unknown
- 2016-02-26 BR BR112017018149A patent/BR112017018149A2/en not_active Application Discontinuation
- 2016-02-26 HU HUE16710378A patent/HUE045862T2/en unknown
- 2016-02-26 EP EP16710378.7A patent/EP3262168B1/en not_active Revoked
- 2016-02-26 SG SG11201706335TA patent/SG11201706335TA/en unknown
- 2016-02-26 KR KR1020177025651A patent/KR20170120126A/en unknown
- 2016-02-26 MY MYPI2017702862A patent/MY180896A/en unknown
- 2016-02-26 MX MX2017011012A patent/MX2017011012A/en unknown
- 2016-02-26 CN CN201680012054.7A patent/CN107406831A/en active Pending
- 2016-02-26 AU AU2016224988A patent/AU2016224988A1/en not_active Abandoned
- 2016-02-26 EA EA201791918A patent/EA201791918A1/en unknown
- 2016-02-26 DK DK16710378.7T patent/DK3262168T3/en active
- 2016-02-26 CA CA2976669A patent/CA2976669A1/en not_active Abandoned
- 2016-02-26 ES ES16710378T patent/ES2751670T3/en active Active
- 2016-02-26 JP JP2017545231A patent/JP6751402B2/en not_active Expired - Fee Related
- 2016-02-26 WO PCT/US2016/019915 patent/WO2016138467A1/en active Application Filing
- 2016-02-26 US US15/055,034 patent/US20160251411A1/en not_active Abandoned
-
2017
- 2017-08-07 IL IL253863A patent/IL253863A0/en unknown
- 2017-08-22 ZA ZA2017/05712A patent/ZA201705712B/en unknown
-
2018
- 2018-06-09 HK HK18107524.0A patent/HK1248272A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
HK1248272A1 (en) | 2018-10-12 |
IL253863A0 (en) | 2017-09-28 |
WO2016138467A1 (en) | 2016-09-01 |
CN107406831A (en) | 2017-11-28 |
CA2976669A1 (en) | 2016-09-01 |
US20160251411A1 (en) | 2016-09-01 |
MX2017011012A (en) | 2017-10-20 |
EP3262168A1 (en) | 2018-01-03 |
ES2751670T3 (en) | 2020-04-01 |
JP2018506295A (en) | 2018-03-08 |
MY180896A (en) | 2020-12-11 |
KR20170120126A (en) | 2017-10-30 |
ZA201705712B (en) | 2020-01-29 |
TW201702380A (en) | 2017-01-16 |
BR112017018149A2 (en) | 2018-04-10 |
HUE045862T2 (en) | 2020-01-28 |
DK3262168T3 (en) | 2019-10-07 |
AU2016224988A1 (en) | 2017-09-07 |
SG11201706335TA (en) | 2017-09-28 |
JP6751402B2 (en) | 2020-09-02 |
EP3262168B1 (en) | 2019-08-21 |
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