EA201692214A1 - Вещества, связывающие ядерные рецепторы - Google Patents

Вещества, связывающие ядерные рецепторы

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Publication number
EA201692214A1
EA201692214A1 EA201692214A EA201692214A EA201692214A1 EA 201692214 A1 EA201692214 A1 EA 201692214A1 EA 201692214 A EA201692214 A EA 201692214A EA 201692214 A EA201692214 A EA 201692214A EA 201692214 A1 EA201692214 A1 EA 201692214A1
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EA
Eurasian Patent Office
Prior art keywords
nuclear
liver disease
deposits
receptor substances
pharmaceutically
Prior art date
Application number
EA201692214A
Other languages
English (en)
Inventor
Джеймс Т. Далтон
Дуэйн Д. Миллер
Майкл Л. Молер
Чжунчжи У
Сеоунг-Соо Хонг
Девеш Сривастава
Original Assignee
ДЖиТиЭкс, ИНК.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДЖиТиЭкс, ИНК. filed Critical ДЖиТиЭкс, ИНК.
Publication of EA201692214A1 publication Critical patent/EA201692214A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P39/06—Free radical scavengers or antioxidants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
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  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

Настоящее изобретение относится к применению соединения или его фармацевтически оптического изомера, фармацевтически приемлемой соли, фармацевтического продукта, N-оксида, гидрата или любой их комбинации представленного структурной формулой VIгде определения радикалов даны в формуле изобретения, для получения лекарственного средства для лечения, отсрочки возникновения, сокращения заболеваемости или снижения серьезности заболевания печени, обусловленного жировыми отложениями, у пациента, причем заболеванием печени, обусловленным жировыми отложениями, является неалкогольный стеатогепатит.
EA201692214A 2007-01-22 2008-01-22 Вещества, связывающие ядерные рецепторы EA201692214A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88147607P 2007-01-22 2007-01-22
US90775407P 2007-04-16 2007-04-16

Publications (1)

Publication Number Publication Date
EA201692214A1 true EA201692214A1 (ru) 2017-11-30

Family

ID=39645049

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201692214A EA201692214A1 (ru) 2007-01-22 2008-01-22 Вещества, связывающие ядерные рецепторы
EA200970707A EA019833B1 (ru) 2007-01-22 2008-01-22 Вещества, связывающие ядерные рецепторы
EA201400056A EA026578B1 (ru) 2007-01-22 2008-01-22 Вещества, связывающие ядерные рецепторы

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA200970707A EA019833B1 (ru) 2007-01-22 2008-01-22 Вещества, связывающие ядерные рецепторы
EA201400056A EA026578B1 (ru) 2007-01-22 2008-01-22 Вещества, связывающие ядерные рецепторы

Country Status (15)

Country Link
US (1) US9078888B2 (ru)
EP (2) EP2647376A1 (ru)
JP (4) JP5484914B2 (ru)
KR (3) KR101763674B1 (ru)
CN (2) CN101641013B (ru)
AU (1) AU2008209581B2 (ru)
BR (1) BRPI0806371A2 (ru)
CA (1) CA2676066C (ru)
EA (3) EA201692214A1 (ru)
ES (1) ES2475193T3 (ru)
IL (2) IL199996A (ru)
IS (1) IS8842A (ru)
MX (1) MX2009007831A (ru)
NO (1) NO20092822L (ru)
WO (1) WO2008091555A2 (ru)

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