EA201691883A1 - Жидкая композиция, содержащая соединение, нейтрализующее gm-csf - Google Patents

Жидкая композиция, содержащая соединение, нейтрализующее gm-csf

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Publication number
EA201691883A1
EA201691883A1 EA201691883A EA201691883A EA201691883A1 EA 201691883 A1 EA201691883 A1 EA 201691883A1 EA 201691883 A EA201691883 A EA 201691883A EA 201691883 A EA201691883 A EA 201691883A EA 201691883 A1 EA201691883 A1 EA 201691883A1
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Eurasian Patent Office
Prior art keywords
csf
compound
composition
neutralizing
composition containing
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EA201691883A
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English (en)
Inventor
Уиллоу Дилузио
Фун Нгуйен
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Такеда Гмбх
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Application filed by Такеда Гмбх filed Critical Такеда Гмбх
Publication of EA201691883A1 publication Critical patent/EA201691883A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

Настоящее изобретение относится к водным композициям, содержащим соединение, нейтрализующее GM-CSF, в концентрации по меньшей мере примерно 20 мг/мл, регулятор тоничности, буфер и один или более поверхностно-активных веществ, аминокислот, антиоксидантов и/или хелатирующих агентов, где композиция является стабильной. Ингредиенты композиции предпочтительно обеспечивают стабильность соединения, нейтрализующего GM-CSF, при долговременном хранении. В предпочтительном аспекте композиция предназначена для применения в терапии, предпочтительно для применения в лечении воспалительных и аутоиммунных заболеваний, предпочтительно включая аллергические и псориатические расстройства, а также артритные и астматические расстройства.
EA201691883A 2014-05-07 2015-05-04 Жидкая композиция, содержащая соединение, нейтрализующее gm-csf EA201691883A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP14167405 2014-05-07
US201461994319P 2014-05-16 2014-05-16
US201462043636P 2014-08-29 2014-08-29
PCT/EP2015/059709 WO2015169742A1 (en) 2014-05-07 2015-05-04 Liquid formulation comprising gm-csf neutralizing compound

Publications (1)

Publication Number Publication Date
EA201691883A1 true EA201691883A1 (ru) 2017-05-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691883A EA201691883A1 (ru) 2014-05-07 2015-05-04 Жидкая композиция, содержащая соединение, нейтрализующее gm-csf

Country Status (14)

Country Link
US (1) US11173208B2 (ru)
EP (1) EP3139960B1 (ru)
JP (1) JP6769879B2 (ru)
KR (1) KR102385802B1 (ru)
CN (1) CN106659785B (ru)
AR (1) AR100268A1 (ru)
AU (1) AU2015257798C1 (ru)
BR (1) BR112016025126B1 (ru)
CA (1) CA2946230A1 (ru)
EA (1) EA201691883A1 (ru)
MX (1) MX2016014411A (ru)
PH (1) PH12016502100A1 (ru)
TW (1) TWI682788B (ru)
WO (1) WO2015169742A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190255A1 (ar) 2017-04-28 2019-10-27 Amgen Inc صيغ أجسام مضادة لـ rankl بشري، وطرق لاستخدامها
CN107167613B (zh) * 2017-06-22 2018-10-02 深圳清华大学研究院 用于等离子体金芯片的蛋白点样缓冲液
KR20210070314A (ko) * 2018-10-01 2021-06-14 암젠 인크 이중특이적 항체의 응집을 감소시키는 방법
US11684655B2 (en) 2019-05-31 2023-06-27 Spectrum Pharmaceuticals, Inc. Methods of treating neutorpenia using G-CSF protein complex
WO2021081326A1 (en) * 2019-10-25 2021-04-29 Amgen Inc. Compositions and methods for minimizing protein loss at low protein concentrations
KR20230124910A (ko) * 2020-12-04 2023-08-28 씨에스엘 이노베이션 피티와이 엘티디 염증성 피부 상태 치료 방법
KR102375269B1 (ko) * 2021-01-27 2022-03-17 한미약품 주식회사 단백질 액상 제제 및 이의 제조방법
JP2024518536A (ja) * 2021-05-12 2024-05-01 アナプティスバイオ インコーポレイティッド 抗体組成物
WO2024114735A1 (en) * 2022-12-01 2024-06-06 I-Mab Biopharma (Hangzhou) Co., Ltd. Liquid pharmaceutical formulation of anti-gm-csf antibody and uses thereof

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4783441A (en) 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE3583880D1 (de) 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5747032A (en) 1990-08-10 1998-05-05 Amrad Corporation Limited Monoclonal antibody to human granulocyte macrophage colony stimulating factor
US5580856A (en) 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
DK1516628T3 (da) 1995-07-27 2013-09-08 Genentech Inc Stabil, isotonisk lyofiliseret proteinformulering
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
KR100508289B1 (ko) 1998-04-21 2005-08-17 마이크로메트 에이지 Ｃｄ１９×ｃｄ３ 특이 폴리펩티드 및 그의 용도
AU2002363339B2 (en) * 2001-11-08 2008-02-07 Abbvie Biotechnology Ltd Stable liquid pharmaceutical formulation of IGG antibodies
SI1478394T1 (sl) 2002-02-27 2008-12-31 Immunex Corp STABILIZIRAN TNFR-Fc SESTAVEK Z ARGININOM
US7511476B2 (en) * 2005-01-04 2009-03-31 Digisensors, Inc. Electromagnetic sensor systems and methods of use thereof
PL1874819T3 (pl) * 2005-04-18 2015-10-30 Amgen Res Munich Gmbh Przeciwciała neutralizujące ludzki czynnik stymulujący wzrost kolonii granulocytów i makrofagów
RU2447085C2 (ru) 2005-05-18 2012-04-10 МорфоСис АГ Анти-gm-csf антитела и их применение
JP4736037B2 (ja) 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
KR101486183B1 (ko) 2006-02-08 2015-01-28 모르포테크, 인크. 항원성 ｇｍ-ｃｓｆ 펩티드 및 ｇｍ-ｃｓｆ에 대한 항체
US8263075B2 (en) 2006-03-27 2012-09-11 Medimmune Limited Antibody molecule for human GM-CSF receptor alpha
EP1970384A1 (en) 2007-03-14 2008-09-17 Ganymed Pharmaceuticals AG Monoclonal antibodies for treatment of cancer
AU2008269086B2 (en) 2007-06-25 2014-06-12 Amgen Inc. Compositions of specific binding agents to hepatocyte growth factor
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
EP2559706A1 (en) 2007-11-13 2013-02-20 Evec Inc. Monoclonal antibodies that bind to hGM-CSF and medical compositions comprising same
US8168183B2 (en) 2008-04-28 2012-05-01 Kalobios Pharmaceuticals, Inc. Antibodies to granulocyte-macrophage colony-stimulating factor
CN102271707B (zh) * 2008-10-29 2015-04-08 阿布林克斯公司 单域抗原结合性分子的制剂
WO2011080209A2 (en) * 2009-12-29 2011-07-07 F. Hoffmann-La Roche Ag Novel antibody formulation
EP3345923A1 (en) * 2012-09-20 2018-07-11 MorphoSys AG Treatment for rheumatoid arthritis with anti-gm-csf antibody
AR093297A1 (es) * 2012-10-31 2015-05-27 Amgen Res (Munich) Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf

Also Published As

Publication number Publication date
MX2016014411A (es) 2017-04-06
CA2946230A1 (en) 2015-11-12
BR112016025126B1 (pt) 2024-02-15
PH12016502100A1 (en) 2017-02-06
JP2017514868A (ja) 2017-06-08
EP3139960A1 (en) 2017-03-15
WO2015169742A1 (en) 2015-11-12
KR102385802B1 (ko) 2022-04-13
BR112016025126A8 (pt) 2022-08-09
TWI682788B (zh) 2020-01-21
AU2015257798A1 (en) 2016-11-17
AU2015257798C1 (en) 2020-10-22
AU2015257798B2 (en) 2020-04-23
US20170252436A1 (en) 2017-09-07
TW201622702A (zh) 2016-07-01
AR100268A1 (es) 2016-09-21
CN106659785B (zh) 2021-04-30
BR112016025126A2 (pt) 2018-02-20
CN106659785A (zh) 2017-05-10
KR20160149210A (ko) 2016-12-27
US11173208B2 (en) 2021-11-16
JP6769879B2 (ja) 2020-10-14
EP3139960B1 (en) 2024-01-17

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