EA201690908A1 - Pyrazolopyrmidine compounds - Google Patents

Pyrazolopyrmidine compounds

Info

Publication number
EA201690908A1
EA201690908A1 EA201690908A EA201690908A EA201690908A1 EA 201690908 A1 EA201690908 A1 EA 201690908A1 EA 201690908 A EA201690908 A EA 201690908A EA 201690908 A EA201690908 A EA 201690908A EA 201690908 A1 EA201690908 A1 EA 201690908A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolopyrmidine
compounds
methods
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
EA201690908A
Other languages
Russian (ru)
Other versions
EA029372B1 (en
Inventor
Радослав Лауфер
Грейс Нг
Сцзе-Вань Ли
Хайнц В. Паулс
Юн Лю
Нарендра Кумар Б. Пател
Original Assignee
Юниверсити Хелс Нетуорк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2013/000957 external-priority patent/WO2014075168A1/en
Application filed by Юниверсити Хелс Нетуорк filed Critical Юниверсити Хелс Нетуорк
Publication of EA201690908A1 publication Critical patent/EA201690908A1/en
Publication of EA029372B1 publication Critical patent/EA029372B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

В настоящем изобретении предложено соединение, представленное следующей структурной формулой:или его фармацевтически приемлемая соль. Также описаны фармацевтические композиции и способы их применения.The present invention provides a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof. Also described pharmaceutical compositions and methods for their use.

EA201690908A 2013-11-15 2014-11-14 Pyrazolopyrimidine compounds EA029372B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CA2013/000957 WO2014075168A1 (en) 2012-11-16 2013-11-15 Pyrazolopyrimidine compounds
PCT/CA2014/051091 WO2015070349A1 (en) 2012-11-16 2014-11-14 Pyrazolopyrimidine compounds

Publications (2)

Publication Number Publication Date
EA201690908A1 true EA201690908A1 (en) 2016-09-30
EA029372B1 EA029372B1 (en) 2018-03-30

Family

ID=56617958

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201690908A EA029372B1 (en) 2013-11-15 2014-11-14 Pyrazolopyrimidine compounds

Country Status (2)

Country Link
JP (1) JP6095857B2 (en)
EA (1) EA029372B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017299850B2 (en) * 2016-07-18 2021-05-27 University Health Network Solid forms of TTK inhibitor
CA3101035A1 (en) * 2018-05-23 2019-11-28 University Health Network Methods of treating cancers characterized by a high expression level of spindle and kinetochore associated complex subunit 3 (ska3) gene

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052315A2 (en) * 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US20070179161A1 (en) * 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
ES2339670T3 (en) * 2003-12-23 2010-05-24 Novartis Ag BICYCLE HYPERCYCLIC INHIBITORS OF QUINASA P-38.
EP1942900B1 (en) * 2005-10-06 2015-06-03 Merck Sharp & Dohme Corp. Use of pyrazolo [1,5-a] pyrimidine derivatives for inhibiting kinases methods for inhibiting protein kinases
EP1873157A1 (en) * 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
AU2008279759A1 (en) * 2007-07-20 2009-01-29 Merck & Co., Inc. Pyrazolo[1,5-a]pyrimidine derivatives
CA2801031A1 (en) * 2010-06-01 2011-12-08 Bayer Intellectual Property Gmbh Substituted imidazopyrazines
EP2651945A1 (en) * 2010-12-17 2013-10-23 Bayer Intellectual Property GmbH 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders
JP2014503521A (en) * 2010-12-17 2014-02-13 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Imidazopyrazines for use as MPS-1 and TKK inhibitors in the treatment of hyperproliferative disorders
ES2545135T3 (en) * 2011-04-06 2015-09-08 Bayer Pharma Aktiengesellschaft Substituted Imidazopyridines and intermediates thereof
CA2889919C (en) * 2012-11-16 2021-08-17 University Health Network Pyrazolopyrimidine compounds

Also Published As

Publication number Publication date
JP6095857B2 (en) 2017-03-15
EA029372B1 (en) 2018-03-30
JP2016537354A (en) 2016-12-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM