EA201690712A1 - Композиции из фрагментов белков шелка и изделия, изготовленные из них - Google Patents

Композиции из фрагментов белков шелка и изделия, изготовленные из них

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Publication number
EA201690712A1
EA201690712A1 EA201690712A EA201690712A EA201690712A1 EA 201690712 A1 EA201690712 A1 EA 201690712A1 EA 201690712 A EA201690712 A EA 201690712A EA 201690712 A EA201690712 A EA 201690712A EA 201690712 A1 EA201690712 A1 EA 201690712A1
Authority
EA
Eurasian Patent Office
Prior art keywords
composition
protections
silk
fragments
compositions
Prior art date
Application number
EA201690712A
Other languages
English (en)
Other versions
EA036027B1 (ru
Inventor
Грегори Х. Алтман
Ребекка Л. Хоран
Рейчел Ли Дау
Рейчел М. Линд
Дилан С. Хаас
Original Assignee
Силк Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Силк Терапьютикс, Инк. filed Critical Силк Терапьютикс, Инк.
Publication of EA201690712A1 publication Critical patent/EA201690712A1/ru
Publication of EA036027B1 publication Critical patent/EA036027B1/ru

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    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D33/00—Containers or accessories specially adapted for handling powdery toiletry or cosmetic substances
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    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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Abstract

Описана композиция, содержащая белковые фрагменты на основе чистого фиброина шелка, в основном свободные от серицина, где композиция обладает средней среднемассовой молекулярной массой в диапазоне от приблизительно 17 до приблизительно 38 кДа, где композиция обладает полидисперсностью между приблизительно 1,5 и приблизительно 3,0, где композиция является, по существу, гомогенной, где композиция содержит между 0 и приблизительно 500 м.д. неорганических остатков и где композиция содержит между 0 и приблизительно 500 м.д. органических остатков.
EA201690712A 2013-09-30 2014-09-30 Композиция из фрагментов белков шелка (варианты) и изделия, изготовленные из них EA036027B1 (ru)

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US14/503,021 US9187538B2 (en) 2013-09-30 2014-09-30 Stable silk protein fragment compositions
PCT/US2014/058462 WO2015048805A1 (en) 2013-09-30 2014-09-30 Silk potein fragment compositions and articles manufactured therefrom
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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201907426UA (en) 2013-09-30 2019-09-27 Evolved By Nature Inc Silk protein fragment compositions and articles manufactured therefrom
US9394355B2 (en) 2014-08-20 2016-07-19 Silk Technologies, Ltd. Fibroin-derived protein composition
KR20170099920A (ko) 2014-12-02 2017-09-01 실크 테라퓨틱스, 인코퍼레이티드 실크 성능 의류와 제품들 및 이의 제조 방법
WO2016115159A1 (en) * 2015-01-12 2016-07-21 Silk Therapeutics, Inc. Preserved silk protein fragment compositions and articles
ES2864901T3 (es) * 2015-04-29 2021-10-14 Evolved By Nature Inc Composiciones humectantes basadas en seda y métodos de las mismas
KR20180072664A (ko) 2015-07-14 2018-06-29 실크 테라퓨틱스, 인코퍼레이티드 실크 성능 의류와 제품들 및 이의 제조 방법
CN109640694A (zh) 2016-04-08 2019-04-16 康奈尔大学 使用丝衍生蛋白质增强伤口愈合的方法
AU2017310520A1 (en) 2016-08-12 2019-03-21 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
US10857262B2 (en) 2016-10-31 2020-12-08 Sofregen Medical, Inc. Compositions comprising low molecular weight silk fibroin fragments and plasticizers
US20230190997A1 (en) * 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
SG11201913229PA (en) 2017-06-26 2020-01-30 Evolved By Nature Inc Silk-hyaluronic acid based tissue fillers and methods of using the same
CN107417471A (zh) * 2017-09-06 2017-12-01 汪建利 肥料省一半、作物不减产的土壤肥力激活剂及其制备方法
WO2019067745A1 (en) 2017-09-27 2019-04-04 Silk, Inc. SILK-COATED FABRICS, PRODUCTS AND PREPARATION METHODS THEREFOR
US20210236644A1 (en) 2017-11-10 2021-08-05 Cocoon Biotech Inc. Ocular applications of silk-based products
CN108546290B (zh) * 2018-03-27 2021-07-27 宜州市壮之都丝绸家纺有限公司 一种蚕丝的提取方法
CN118374643A (zh) 2018-07-18 2024-07-23 自然进化公司 丝涂布皮革及产品及制备其的方法
CA3124196A1 (en) * 2018-12-19 2020-06-25 Evolved By Nature, Inc. Silk-hyaluronic acid tissue fillers and methods of making and using the same
TWI691531B (zh) * 2019-02-11 2020-04-21 南臺學校財團法人南臺科技大學 蠶絲蛋白膜的製造方法
MX2021012659A (es) * 2019-04-16 2021-11-12 Evolved By Nature Inc Composiciones de seda para el cuidado del cabello.
EP3968906B1 (en) * 2019-05-13 2024-07-10 E. Aubrey Woodroof Improved skin substitute adherence, stretchability, and compliance for skin substitutes
BR112021024634A2 (pt) * 2019-06-06 2022-01-18 Evolved By Nature Inc Método de tratamento ou prevenção de um distúrbio, doença ou condição aliviada pela estimulação ou modulação da expressão de colágeno
WO2021035087A1 (en) * 2019-08-20 2021-02-25 Evolved By Nature, Inc. Silk personal care compositions
JP2021054771A (ja) * 2019-09-30 2021-04-08 Ｓｐｉｂｅｒ株式会社 保水性付与剤、及び保水性を付与する方法
US11707497B2 (en) 2019-10-09 2023-07-25 Brain Health Holding Llc Methods and compositions with purified Bombyx mori cocoon silk peptide fiber and refined Buglossoides arvensis seed oil providing anti-inflammatory effects and neuroprotection for disease states
US11357810B2 (en) 2019-10-09 2022-06-14 Brain Health Holding Llc Compositions with purified Bombyx mori cocoon silk peptide fiber and refined Buglossoides arvensis seed oil having synergistic effects for improving memory, focus, and cognitive function, and related methods
EP4045124A4 (en) 2019-10-15 2024-01-24 Sofregen Medical, Inc. DISPENSING DEVICES FOR DISPENSING AND METHOD FOR DISPENSING COMPOSITIONS
CN114213517B (zh) * 2021-02-08 2024-07-09 复向丝泰医疗科技(苏州)有限公司 利用切向流超滤技术制备可控高浓度丝素蛋白溶液的方法
WO2022197871A1 (en) * 2021-03-16 2022-09-22 Evolved By Nature, Inc. Silk coated synthetic fabrics
WO2022246342A1 (en) 2021-05-21 2022-11-24 Cambridge Crops, Inc. d/b/a Mori Systems and methods for manufacturing a silk fibroin solution and powders containing silk fibroin
US11864569B2 (en) 2021-08-16 2024-01-09 Cambridge Crops, Inc. Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin
WO2023081711A1 (en) 2021-11-02 2023-05-11 Bolt Threads, Inc. Cosmetic and personal care compositions comprising recombinant silk
WO2023215264A1 (en) * 2022-05-02 2023-11-09 Cocoon Biotech Inc. Methods for reducing impurities in silk fibroin preparations
WO2024119107A1 (en) * 2022-12-01 2024-06-06 Evolved By Nature, Inc. Lyophilized and sprayable silk fibroin and modified silk fibroin forms

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26501A (en) 1859-12-20 Gbaving-dock
US64499A (en) 1867-05-07 Improved apparatus foe extracting oil from herbs, and for other purposes
US445875A (en) 1891-02-03 Burial apparatus
US687221A (en) 1901-09-25 1901-11-26 Thomas T Gaff Grits and the art or process of making same.
KR940011689B1 (ko) * 1992-07-02 1994-12-23 재단법인 한국전자통신연구소 온도보상용 유전체 자기 조성물
JPH0767686A (ja) * 1993-09-06 1995-03-14 Shinano Kenshi Co Ltd 低分子量の絹フィブロインペプチドの製造方法
AU2022599A (en) 1997-12-31 1999-07-19 Kimberly-Clark Worldwide, Inc. Method of reducing molecular weights and polydispersity indices of polymers of ethylene oxide
US5902932A (en) 1998-01-09 1999-05-11 Granville-Phillips Company Force balancing capacitance manometer
US7410489B2 (en) 1998-09-28 2008-08-12 Daos Limited Internal cord fixation device
JP2000143472A (ja) * 1998-11-10 2000-05-23 Hiroshi Akai 紫外線吸収機能を有する化粧剤
JP2001163899A (ja) * 1999-12-09 2001-06-19 Natl Inst Of Sericultural & Entomological Science 機能性絹フィブロインの製造方法とその利用
JP3256210B2 (ja) 2000-01-18 2002-02-12 百樹 中川 繊維処理剤及び繊維の処理方法
ES2440190T3 (es) 2000-03-03 2014-01-28 C. R. Bard, Inc. Dispositivo endoscópico de aposición de tejido con múltiples puertos de succión
US20030220646A1 (en) 2002-05-23 2003-11-27 Thelen Sarah L. Method and apparatus for reducing femoral fractures
US6712830B2 (en) 2000-03-15 2004-03-30 Esplin Medical Inventions, L.L.C. Soft tissue anchor
MXPA03000203A (es) 2000-06-29 2004-09-13 Biosyntech Canada Inc Composicion y metodo para la reparacion y regeneracion del cartilago y otros tejidos.
US20030206897A1 (en) 2000-09-13 2003-11-06 The Procter & Gamble Company Cosmetic compositions
US6565564B2 (en) 2000-12-14 2003-05-20 Synthes U.S.A. Multi-pin clamp and rod attachment
US6558344B2 (en) 2001-02-09 2003-05-06 Westmed, Inc. Wound irrigation device
US7713306B2 (en) 2001-02-23 2010-05-11 Biomet Manufacturing Corp. Method and apparatus for acetabular reconstruction
US7597715B2 (en) 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
KR20020091244A (ko) * 2001-03-14 2002-12-05 도쿄 노고 다이가쿠쵸가 다이효스루 니혼코쿠 견 및 견모양 재료의 섬유 및 필름의 제조방법
US8317871B2 (en) 2001-07-27 2012-11-27 Biomet Manufacturing Corp. Modular humeral head resurfacing system
US7235091B2 (en) 2002-06-20 2007-06-26 Brian Thornes Apparatus and method for fixation of ankle syndesmosis
ITVR20010098A1 (it) * 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
DE60230907D1 (de) 2001-10-25 2009-03-05 Univ Connecticut Fibroinzusammensetzungen und verfahren zu deren herstellung
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
JP4480936B2 (ja) 2001-11-26 2010-06-16 オリンパス株式会社 組織穿刺用システム
WO2003045336A1 (fr) * 2001-11-29 2003-06-05 National Institute Of Agrobiological Sciences Emulsifiant et procede d'elaboration correspondant
DE50200594D1 (de) 2002-02-08 2004-08-12 Storz Karl Gmbh & Co Kg Ankerelement zum Verankern eines Ligamenttransplantates
US7416556B2 (en) 2002-06-06 2008-08-26 Abbott Laboratories Stop-cock suture clamping system
JP3772207B2 (ja) 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
AU2003249366A1 (en) 2002-06-24 2004-01-06 Tufts University Silk biomaterials and methods of use thereof
US7056308B2 (en) 2002-10-04 2006-06-06 Dsu Medical Corporation Medical device with elastomeric penetrable wall and inner seal
US7632873B2 (en) 2002-12-13 2009-12-15 L'oreal S.A. Cosmetic dermatological composition comprising at least one gradient copolymer, makeup comprising the cosmetic or dermatological composition and cosmetic method using the composition
FR2848417B1 (fr) 2002-12-13 2006-06-16 Oreal Composition cosmetique ou dermatologique comprenant un copolymere a gradient et procede cosmetique de maquillage ou de soin employant ledit copolymere
JP3738255B2 (ja) 2003-02-21 2006-01-25 株式会社オードレマン 非結晶性絹フィブロインを含有する化粧料
JP3906927B2 (ja) * 2003-03-14 2007-04-18 独立行政法人農業生物資源研究所 絹タンパク由来機能性ポリペプチドの製造と利用
US7115388B2 (en) * 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
CA2562415C (en) 2003-04-10 2015-10-27 Tufts University Concentrated aqueous silk fibroin solutions free of organic solvents and uses thereof
US7456147B2 (en) * 2003-05-14 2008-11-25 Dow Corning, Corporation Controlled release of active agents utilizing repeat sequence protein polymers
US20040267317A1 (en) 2003-06-26 2004-12-30 Laurence Higgins Methods for attaching tissue to bone
EP1648478A1 (en) 2003-07-09 2006-04-26 SDGI Holdings, Inc. Isolation of bone marrow fraction rich in connective tissue growth components and the use thereof to promote connective tissue formation
US20050049598A1 (en) 2003-08-29 2005-03-03 West Hugh S. Suture pulley for use with graft tensioning device
WO2005037137A2 (en) 2003-10-17 2005-04-28 Therics, Inc. Spinal cage insert, filler piece and method of manufacturing
DE10349953B4 (de) 2003-10-24 2006-06-01 Karl Storz Gmbh & Co. Kg Vorrichtung zum Fixieren und Spannen zumindest eines Zugfadens für das Anlegen einer Neovagina
US20050090827A1 (en) 2003-10-28 2005-04-28 Tewodros Gedebou Comprehensive tissue attachment system
US7357810B2 (en) 2003-12-18 2008-04-15 Ethicon, Inc. High strength suture with absorbable core and suture anchor combination
WO2005069957A2 (en) 2004-01-20 2005-08-04 Alexander Michalow Unicondylar knee implant
US7455683B2 (en) 2004-02-26 2008-11-25 Depuy Mitek, Inc. Methods and devices for repairing triangular fibrocartilage complex tears
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
JP4700384B2 (ja) 2004-04-07 2011-06-15 オリンパス株式会社 医療用結紮縫合装置及び医療用結紮縫合システム
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US7585311B2 (en) 2004-06-02 2009-09-08 Kfx Medical Corporation System and method for attaching soft tissue to bone
JP4896017B2 (ja) 2004-07-31 2012-03-14 バイオグランド シーオー エル ティー ディー 脳疾患または頭脳機能改善のための組成物
US7754243B2 (en) 2004-08-03 2010-07-13 Clemson University Research Foundation Aqueous suspension of nanoscale drug particles from supercritical fluid processing
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US20060195106A1 (en) 2005-02-02 2006-08-31 Jones Bryan S Ultrasonic cutting device
US7825083B2 (en) 2005-02-10 2010-11-02 Spine Wave, Inc. Synovial fluid barrier
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
KR100841742B1 (ko) * 2006-12-14 2008-06-27 화인코주식회사 하이드로겔 마스크 팩, 이의 제조 방법 및 이의 제조에이용되는 조성물
CN1985791B (zh) * 2006-12-27 2010-05-19 浙江大学 护肤丝素凝胶霜膏的制备方法
JP2008169171A (ja) * 2007-01-15 2008-07-24 Luc Sangyo Kk 絹フィブロイン含有組成物及びその製造法
ES2527125T3 (es) 2007-05-29 2015-01-20 Trustees Of Tufts College Método para la gelificación de fibroína de seda usando sonicación
US9808557B2 (en) 2007-08-10 2017-11-07 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
US20100254961A1 (en) 2007-09-05 2010-10-07 Taiyokagaku Co., Ltd. Water-soluble electrospun sheet
US9068282B2 (en) 2008-04-08 2015-06-30 Trustees Of Tufts College System and method for making biomaterial structures
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
CN102271724B (zh) 2008-10-09 2015-10-14 塔夫茨大学信托人 含有甘油的改性丝膜
US9427499B2 (en) 2008-11-17 2016-08-30 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti-adhesion barriers and anti-thrombotic materials
US20110189292A1 (en) 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
ES2423055T3 (es) * 2009-04-20 2013-09-17 Allergan, Inc. Hidrogeles de fibroína de seda y usos de éstos
US20120070427A1 (en) * 2009-06-01 2012-03-22 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
US9074302B2 (en) 2009-09-28 2015-07-07 Trustees Of Tufts College Methods of making drawn silk fibers
JP5730317B2 (ja) 2009-09-29 2015-06-10 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ 絹ナノスフェアおよび絹マイクロスフェアならびにこれらを作製する方法
JP2013533754A (ja) 2010-04-12 2013-08-29 タフツ・ユニバーシティ 絹電子部品
JP5827790B2 (ja) * 2010-04-28 2015-12-02 東レ・ダウコーニング株式会社 高級アルコール変性シリコーンを含有してなる化粧料および皮膚外用剤
WO2011160098A2 (en) 2010-06-17 2011-12-22 Tufts University Silk optical particles and uses thereof
US8894992B2 (en) 2010-08-19 2014-11-25 Allergan, Inc. Compositions and soft tissue replacement methods
US8926963B2 (en) 2010-08-19 2015-01-06 Allergan, Inc. Compositions and soft tissue replacement methods
US8741281B2 (en) 2010-08-19 2014-06-03 Allergan, Inc. Compositions and soft tissue replacement methods
US8900571B2 (en) 2010-08-19 2014-12-02 Allergan, Inc. Compositions and soft tissue replacement methods
US9566365B2 (en) 2010-09-01 2017-02-14 Trustees Of Tufts College Silk fibroin and polyethylene glycol-based biomaterials
JP5985795B2 (ja) * 2011-02-09 2016-09-06 八藤　眞 セリシンペプチドの製造方法
US8972214B2 (en) * 2011-04-21 2015-03-03 Microchip Technology Incorporated Touch sense determined by characterizing impedance changes in a transmission line
AU2012245198B2 (en) 2011-04-21 2017-07-13 Trustees Of Tufts College Compositions and methods for stabilization of active agents
US8551538B2 (en) * 2011-08-18 2013-10-08 Golden Pearl Investment LLC Skin formulation, preparation and uses thereof
WO2013070907A1 (en) 2011-11-08 2013-05-16 Tufts University A silk-based scaffold platform for engineering tissue constructs
KR20130052878A (ko) 2011-11-14 2013-05-23 강용구 당뇨 개선 기능을 가지는 실크 펩타이드 조성물
KR20130052910A (ko) 2011-11-14 2013-05-23 강용구 고콜레스테롤증 및 고지혈증 개선의 복합 기능을 가지는 실크 펩타이드 조성물
KR20130053494A (ko) 2011-11-14 2013-05-24 강용구 당뇨, 고콜레스테롤증 및 고지혈증 개선의 복합 기능을 가지는 실크 펩타이드의 제조방법
WO2013159101A1 (en) 2012-04-20 2013-10-24 Trustees Of Tufts College Silk fibroin-based personal care compositions
CN104254341B (zh) * 2012-04-25 2018-04-13 日立化成株式会社 药剂缓释载体
US20150183841A1 (en) 2012-07-09 2015-07-02 Trustees Of Tufts College High molecular weight silk fibroin and uses thereof
US20140222152A1 (en) 2013-02-06 2014-08-07 Tufts University Implantable intervertebral disc devices and uses thereof
WO2014145002A2 (en) 2013-03-15 2014-09-18 Kluge Jonathan A Low molecular weight silk compositions and stabilizing silk compositions
SG10201907426UA (en) 2013-09-30 2019-09-27 Evolved By Nature Inc Silk protein fragment compositions and articles manufactured therefrom

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US10166177B2 (en) 2019-01-01
US20230085841A1 (en) 2023-03-23
US20220226223A1 (en) 2022-07-21
JP6775751B2 (ja) 2020-10-28
US11298310B2 (en) 2022-04-12
US10610478B2 (en) 2020-04-07
JP2021001198A (ja) 2021-01-07
US20190070088A1 (en) 2019-03-07
JP2024050635A (ja) 2024-04-10
US20160022559A1 (en) 2016-01-28
US20200188268A1 (en) 2020-06-18
AU2020203045A1 (en) 2020-05-28
JP7263298B2 (ja) 2023-04-24
JP7423688B2 (ja) 2024-01-29
US20190380944A1 (en) 2019-12-19
KR102379848B1 (ko) 2022-03-28
KR20210153142A (ko) 2021-12-16
BR112016006898A8 (pt) 2020-02-18
MX2016003961A (es) 2018-02-19
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