EA201600128A1 - 2-AMINO-1-HYDROXYETHYL-8-HYDROXYHINOLIN-2 (1H) -ONA SALTS, OWNER OF THE ANTAGONISTIC ACTIVITIES - Google Patents
2-AMINO-1-HYDROXYETHYL-8-HYDROXYHINOLIN-2 (1H) -ONA SALTS, OWNER OF THE ANTAGONISTIC ACTIVITIESInfo
- Publication number
- EA201600128A1 EA201600128A1 EA201600128A EA201600128A EA201600128A1 EA 201600128 A1 EA201600128 A1 EA 201600128A1 EA 201600128 A EA201600128 A EA 201600128A EA 201600128 A EA201600128 A EA 201600128A EA 201600128 A1 EA201600128 A1 EA 201600128A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- salts
- hydroxyhinolin
- ona
- owner
- hydroxyethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
В заявке описаны кристаллические соли присоединения (i) производных 8-гидроксихинолин-2(1Н)-она с (ii) дикарбоновой кислотой или сульфимидом или их фармацевтически приемлемые сольваты.The application describes crystalline addition salts (i) of 8-hydroxyquinoline-2 (1H) -one derivatives with (ii) dicarboxylic acid or sulfimide, or their pharmaceutically acceptable solvates.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13382304 | 2013-07-25 | ||
PCT/EP2014/065965 WO2015011244A1 (en) | 2013-07-25 | 2014-07-24 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201600128A1 true EA201600128A1 (en) | 2016-07-29 |
EA035436B1 EA035436B1 (en) | 2020-06-15 |
Family
ID=48917474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201600128A EA035436B1 (en) | 2013-07-25 | 2014-07-24 | Crystalline addition salt of trans-4-[{3-[5-({[(2r)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-1h-1,2,3-benzotriazol-1-yl]propyl}(methyl)amino]cyclohexylhydroxy(di-2-thienyl)acetate saccharinate having both muscarinic receptor antagonist and beta-2 adrenergic receptor agonist activities |
Country Status (36)
Country | Link |
---|---|
US (1) | US9579316B2 (en) |
EP (1) | EP3024489B1 (en) |
JP (1) | JP6374962B2 (en) |
KR (1) | KR102338155B1 (en) |
CN (2) | CN112321579A (en) |
AR (1) | AR097079A1 (en) |
AU (1) | AU2014295028B2 (en) |
BR (1) | BR112016001295B1 (en) |
CA (1) | CA2917596C (en) |
CL (1) | CL2016000187A1 (en) |
CR (1) | CR20160043A (en) |
CY (1) | CY1122920T1 (en) |
DK (1) | DK3024489T3 (en) |
DO (1) | DOP2016000011A (en) |
EA (1) | EA035436B1 (en) |
ES (1) | ES2788627T3 (en) |
HK (1) | HK1219043A1 (en) |
HR (1) | HRP20200670T1 (en) |
HU (1) | HUE049441T2 (en) |
IL (1) | IL243173B (en) |
LT (1) | LT3024489T (en) |
MX (1) | MX360837B (en) |
MY (1) | MY184681A (en) |
NI (1) | NI201600012A (en) |
NZ (1) | NZ715128A (en) |
PE (1) | PE20160173A1 (en) |
PH (1) | PH12016500125B1 (en) |
PL (1) | PL3024489T3 (en) |
PT (1) | PT3024489T (en) |
RS (1) | RS60185B1 (en) |
SG (1) | SG11201510682YA (en) |
SI (1) | SI3024489T1 (en) |
TW (1) | TWI641373B (en) |
UY (1) | UY35678A (en) |
WO (1) | WO2015011244A1 (en) |
ZA (1) | ZA201509203B (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
SG11201504452WA (en) | 2012-12-18 | 2015-07-30 | Almirall Sa | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activity |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
TWI643853B (en) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES |
CN105473133A (en) | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | Dry powder formulations and methods of use |
TW201517906A (en) | 2013-07-25 | 2015-05-16 | Almirall Sa | Combinations comprising MABA compounds and corticosteroids |
TWI641373B (en) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES |
TW201617343A (en) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | New bicyclic derivatives having [beta]2 adrenergic agonist and M3 muscarinic antagonist activities |
CN107074833B (en) * | 2015-07-21 | 2021-05-25 | 四川海思科制药有限公司 | Having beta2Benzo ring derivatives with receptor agonistic and M3 receptor antagonistic activities and application thereof in medicine |
CN106554350B (en) * | 2015-09-29 | 2019-12-20 | 四川海思科制药有限公司 | Benzo heterocyclic derivative with beta 2 agonist activity and its prepn and application |
TW201835041A (en) * | 2017-02-17 | 2018-10-01 | 印度商托仁特生技有限公司 | Compounds with Beta-Adrenergic Agonist and Antimuscarinic Activity |
KR20230040375A (en) | 2017-09-22 | 2023-03-22 | 오티토픽 인코퍼레이티드 | Dry powder compositions with magnesium stearate |
US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
CN113544121A (en) * | 2019-06-06 | 2021-10-22 | 中国医药研究开发中心有限公司 | Heterocyclic derivative with beta 2 receptor agonistic and M receptor antagonistic activities and medical application thereof |
US20230322745A1 (en) * | 2020-09-28 | 2023-10-12 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Fused tricyclic derivative and pharmaceutical application thereof |
WO2023179758A1 (en) * | 2022-03-25 | 2023-09-28 | 正大天晴药业集团股份有限公司 | Crystal of fused tricyclic derivative or pharmaceutically acceptable salt thereof |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1212742B (en) | 1983-05-17 | 1989-11-30 | Dompe Farmaceutici Spa | DIBENZO DERIVATIVES [1,4] PYRID DIAZEPINONIC [1,4] BENZODIAZEPINONIC, PYRID [1,5] BENZODIAZEPINONIC AND THEIR PHARMACOLOGICAL ACTIVITY |
ATE25966T1 (en) | 1983-09-26 | 1987-04-15 | Magis Farmaceutici | AMINOCYCLOHEXANOL DERIVATIVES WITH EXPECTORANT ACTIVITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
JPH03178929A (en) | 1989-09-07 | 1991-08-02 | Glaxo Group Ltd | Therapeutic compound for treating inflammation and allergy |
GB9020051D0 (en) | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
WO1998009632A1 (en) | 1996-09-06 | 1998-03-12 | Merck & Co., Inc. | Methods and compositions for treating preterm labor |
SE9704644D0 (en) | 1997-12-12 | 1997-12-12 | Astra Ab | New use |
US6673908B1 (en) | 1999-02-22 | 2004-01-06 | Nuvelo, Inc. | Tumor necrosis factor receptor 2 |
WO2001014339A2 (en) | 1999-08-20 | 2001-03-01 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
US6806314B2 (en) | 2003-02-03 | 2004-10-19 | Ppg Industries Ohio, Inc. | Coating of Hydroxy-functional polymer(s), crosslinker, and 1,3- and 1,4-cyclohexane dimethanols |
PE20040950A1 (en) | 2003-02-14 | 2005-01-01 | Theravance Inc | BIPHENYL DERIVATIVES AS AGONISTS OF ß2-ADRENERGIC RECEPTORS AND AS ANTAGONISTS OF MUSCARINAL RECEPTORS |
EP1615881A2 (en) | 2003-04-01 | 2006-01-18 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
EP1626970B1 (en) | 2003-05-28 | 2009-07-08 | Theravance, Inc. | Azabicycloalkane compounds as muscarinic receptor antagonists |
WO2005080375A1 (en) | 2004-02-13 | 2005-09-01 | Theravance, Inc. | Crystalline form of a biphenyl compound |
DE102004024453A1 (en) | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New long-acting bronchodilators for the treatment of respiratory diseases |
ES2251867B1 (en) | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA. |
TWI374883B (en) | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
JP2008510015A (en) | 2004-08-16 | 2008-04-03 | セラヴァンス, インコーポレーテッド | Compounds having β2 adrenergic receptor agonist activity and muscarinic receptor antagonist activity |
US7528253B2 (en) | 2004-08-16 | 2009-05-05 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
RU2442771C2 (en) | 2005-08-08 | 2012-02-20 | Арджента Дискавери Лтд | Derivants of bicyclo[2, 2, 1] hept-7-ylamine and their applications |
GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
MX2008011963A (en) | 2006-03-20 | 2008-10-01 | Pfizer Ltd | Amine derivatives. |
GB0613154D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
WO2008017827A2 (en) | 2006-08-08 | 2008-02-14 | Argenta Discovery Limited | Azole and thiazole derivatives and their uses |
GB0702384D0 (en) | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | Chemical compounds |
EP1894568A1 (en) | 2006-08-31 | 2008-03-05 | Novartis AG | Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases |
JP2010505810A (en) | 2006-10-04 | 2010-02-25 | ファイザー・リミテッド | Sulfonamide derivatives as adrenergic and muscarinic antagonists |
GB0700972D0 (en) | 2007-01-18 | 2007-02-28 | Imp Innovations Ltd | Treatment of inflammatory disease |
GB0702413D0 (en) | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New chemical compounds |
WO2008096129A1 (en) | 2007-02-07 | 2008-08-14 | Argenta Discovery Ltd | Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors |
WO2008149110A1 (en) | 2007-06-08 | 2008-12-11 | Argenta Discovery Limited | Bicyclor [2.2.1] hept-7-ylamine derivatives and their use in the treatment of diseases and conditions in which m3 muscarinic receptor activity and beta-adrenergic activity are implicated |
UY31235A1 (en) | 2007-07-21 | 2009-03-02 | NEW PULVERULENT DRUGS CONTAINING TIOTROPY AND SALMETEROL, AS WELL AS LACTOSE AS EXCIPIENT | |
WO2009017813A1 (en) * | 2007-08-02 | 2009-02-05 | Teva Pharmaceutical Industries Ltd. | O-desmethyl venlafaxine saccharinate |
MY149731A (en) | 2008-02-06 | 2013-10-14 | Astrazeneca Ab | Compounds |
CN101544572B (en) | 2008-03-26 | 2013-03-20 | 连云港恒邦医药科技有限公司 | Ambroxol derivative and method for preparing same |
GB0808708D0 (en) | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New compounds 274 |
EP2303266A4 (en) * | 2008-06-20 | 2015-01-21 | Astrazeneca Ab | Pharmaceutical composition comprising a 4-hydroxy-2-oxo-2, 3- dihydro-1, 3-benzothiazol-7-yl compound for modulation of beta2-adrenoreceptor activity |
US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
WO2010015792A1 (en) | 2008-08-06 | 2010-02-11 | Argenta Discovery Limited | Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors |
EP2196465A1 (en) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
PT2599778T (en) | 2009-04-23 | 2017-06-06 | Theravance Respiratory Co Llc | Diamide compounds having muscarinic receptor antagonist and beta 2 adrenergic receptor agonist activity |
EP2426121A4 (en) | 2009-04-30 | 2012-10-31 | Teijin Pharma Ltd | Quaternary ammonium salt compound |
GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
GB201002612D0 (en) * | 2010-02-16 | 2010-03-31 | Jagotec Ag | Improvements in or relating to organic compounds |
EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
ITRM20110083U1 (en) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | PLATE FOR THE CONSTRUCTION OF TRUCKS FOR AIRPLANES |
AR083115A1 (en) | 2010-09-30 | 2013-01-30 | Theravance Inc | CRYSTAL OXALATE SALTS OF A DIAMID COMPOUND |
GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
RU2606121C2 (en) | 2011-06-10 | 2017-01-10 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Compounds having antagonistic activity towards muscarinic receptors and agonist activity to beta2-adrenoreceptors |
EP2718280B1 (en) | 2011-06-10 | 2015-09-16 | Chiesi Farmaceutici S.p.A. | Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
CN104105485B (en) | 2011-11-11 | 2017-04-12 | 吉利德阿波罗公司 | Acc inhibitors and uses thereof |
UA108713C2 (en) | 2011-11-11 | 2015-05-25 | 2-Thiopyrimidinones | |
EP2592077A1 (en) * | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
UA111867C2 (en) | 2011-11-11 | 2016-06-24 | Аллерган, Інк. | PHARMACEUTICAL COMPOSITION AND METHOD OF APPLICATION OF 4-PROGEN-11β-17-21-TRIOL-3,20-DION DERIVATIVES |
TW201427977A (en) | 2012-12-06 | 2014-07-16 | Chiesi Farma Spa | Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
DK3345904T3 (en) | 2012-12-06 | 2020-08-31 | Chiesi Farm Spa | Compounds with muscarinic receptor antagonist and beta2-adrenergic receptor agonist activity |
SG11201504452WA (en) | 2012-12-18 | 2015-07-30 | Almirall Sa | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activity |
TW201440768A (en) | 2013-02-27 | 2014-11-01 | Almirall Sa | Combinations comprising MABA compounds and corticosteroids |
TWI643853B (en) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH β2 ADRENERGIC RECEPTOR AGONIST AND M3 MUSCARINIC RECEPTOR ANTAGONIST ACTIVITIES |
TW201517906A (en) | 2013-07-25 | 2015-05-16 | Almirall Sa | Combinations comprising MABA compounds and corticosteroids |
TWI641373B (en) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | SALTS OF 2-AMINO-1-HYDROXYETHYL-8-HYDROXYQUINOLIN-2(1H)-ONE DERIVATIVES HAVING BOTH MUSCARINIC RECEPTOR ANTAGONIST AND β2 ADRENERGIC RECEPTOR AGONIST ACTIVITIES |
TW201617343A (en) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | New bicyclic derivatives having [beta]2 adrenergic agonist and M3 muscarinic antagonist activities |
-
2014
- 2014-07-22 TW TW103125077A patent/TWI641373B/en active
- 2014-07-24 CN CN202011250238.1A patent/CN112321579A/en active Pending
- 2014-07-24 LT LTEP14747554.5T patent/LT3024489T/en unknown
- 2014-07-24 WO PCT/EP2014/065965 patent/WO2015011244A1/en active Application Filing
- 2014-07-24 AU AU2014295028A patent/AU2014295028B2/en active Active
- 2014-07-24 CA CA2917596A patent/CA2917596C/en active Active
- 2014-07-24 PL PL14747554T patent/PL3024489T3/en unknown
- 2014-07-24 MX MX2016000397A patent/MX360837B/en active IP Right Grant
- 2014-07-24 EP EP14747554.5A patent/EP3024489B1/en active Active
- 2014-07-24 US US14/906,991 patent/US9579316B2/en active Active
- 2014-07-24 PE PE2016000066A patent/PE20160173A1/en unknown
- 2014-07-24 JP JP2016528538A patent/JP6374962B2/en active Active
- 2014-07-24 SI SI201431533T patent/SI3024489T1/en unknown
- 2014-07-24 RS RS20200497A patent/RS60185B1/en unknown
- 2014-07-24 MY MYPI2016700228A patent/MY184681A/en unknown
- 2014-07-24 KR KR1020167002012A patent/KR102338155B1/en active IP Right Grant
- 2014-07-24 SG SG11201510682YA patent/SG11201510682YA/en unknown
- 2014-07-24 DK DK14747554.5T patent/DK3024489T3/en active
- 2014-07-24 BR BR112016001295-0A patent/BR112016001295B1/en active IP Right Grant
- 2014-07-24 CN CN201480042033.0A patent/CN105492027A/en active Pending
- 2014-07-24 HU HUE14747554A patent/HUE049441T2/en unknown
- 2014-07-24 PT PT147475545T patent/PT3024489T/en unknown
- 2014-07-24 EA EA201600128A patent/EA035436B1/en not_active IP Right Cessation
- 2014-07-24 NZ NZ715128A patent/NZ715128A/en unknown
- 2014-07-24 ES ES14747554T patent/ES2788627T3/en active Active
- 2014-07-25 AR ARP140102789A patent/AR097079A1/en not_active Application Discontinuation
- 2014-07-25 UY UY35678A patent/UY35678A/en not_active Application Discontinuation
-
2015
- 2015-12-17 ZA ZA2015/09203A patent/ZA201509203B/en unknown
- 2015-12-17 IL IL24317315A patent/IL243173B/en active IP Right Grant
-
2016
- 2016-01-12 DO DO2016000011A patent/DOP2016000011A/en unknown
- 2016-01-19 PH PH12016500125A patent/PH12016500125B1/en unknown
- 2016-01-20 NI NI201600012A patent/NI201600012A/en unknown
- 2016-01-22 CR CR20160043A patent/CR20160043A/en unknown
- 2016-01-25 CL CL2016000187A patent/CL2016000187A1/en unknown
- 2016-06-13 HK HK16106791.0A patent/HK1219043A1/en unknown
-
2020
- 2020-04-13 CY CY20201100343T patent/CY1122920T1/en unknown
- 2020-04-27 HR HRP20200670TT patent/HRP20200670T1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201600128A1 (en) | 2-AMINO-1-HYDROXYETHYL-8-HYDROXYHINOLIN-2 (1H) -ONA SALTS, OWNER OF THE ANTAGONISTIC ACTIVITIES | |
EA201500875A1 (en) | DERIVATIVES OF THE STATE | |
CL2017001566A1 (en) | Azabicycloothane derivatives as fxr agonists for use in the treatment of liver and gastrointestinal diseases. | |
NI201600152A (en) | FUSED BICYCLIC HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS | |
DK3359542T3 (en) | SPIRO [3H-INDOL-3,2'-PYRROLIDIN] -2 (1H) -ON COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | |
CY1124800T1 (en) | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | |
PH12016500676A1 (en) | Pyrimidine fgfr4 inhibitors | |
UY35834A (en) | PIPERAZINAS DE PIRAZOLO REPLACED AS INHIBITORS OF CASEÍNA QUINASA 1 DELTA AND EPSILON | |
CR20150524A (en) | HETEROARILO COMPOUNDS AND ITS USES | |
MY192467A (en) | 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides | |
EA201790395A1 (en) | AMINOTRIAZIN DERIVATIVES SUITABLE FOR USING AS TANK-BINDING KINASE INHIBITORS | |
EA201692465A1 (en) | CRYSTALLINE SALTS (S) -6 - ((1-ACETYLPIPERIDIN-4-IL) AMINO) -N- (3- (3,4-DIHYDRO-ISOHINOLIN-2 (1H) -YL) -2-HYDROXYPROPIL) Pyrimidine-4-C-Cyropyridine-4-Cyropyridine-4-Cylindiol-4-IL-2). | |
MX2014001885A (en) | 5-FLUORO-4-IMINO-3-(SUBSTITUTED)-3,4-DIHYDROPYRIMIDIN-2-(1H</ i>)-ONE DERIVATIVES. | |
DK3287460T3 (en) | HEMISULPHATE SALT OF 5,10-METHYLENE- (6R) -TETRAHYDROFOLIC ACID | |
UY35274A (en) | COMPOUNDS AND METHODS TO TREAT BACTERIAL INFECTIONS | |
EA201790432A1 (en) | PROBES FOR VISUALIZATION PROTEIN HANTINGTIN | |
EA201592183A1 (en) | BACE INHIBITORS | |
EA201790939A1 (en) | TRIAZOLO [4,5-d] Pyrimidine as an agonist of cannabinoid receptor type 2 | |
EA201400822A1 (en) | DERIVATIVES OF HETEROCYCLIC AMIDES AS AN ANTAGONISTS OF P2HRECEPTOR | |
BR112016027691A2 (en) | TETRAHYDROPYRIDOPYRIMIDINE COMPOUND AND ITS USES | |
EA201591939A1 (en) | Pyrrolo [2,3-d] pyrimidine derivatives as agonists of CB2 receptor | |
CR20160070A (en) | TRIAZOLOPIRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE OF THE SAME | |
RS54716B1 (en) | Heterocyclic compounds and their uses | |
EA201790687A1 (en) | QUINOLINCARBOXAMIDE FOR USE IN THE TREATMENT OF MULTIPLE MYELOMA | |
EA201491227A1 (en) | NEW MORFOLINIL DERIVATIVES SUITABLE FOR USING AS MOGAT-2 INHIBITORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KG TJ TM |