EA201592055A1 - 11-гидроксилпроизводные желчных кислот и их аминокислотные конъюгаты в качестве модуляторов фарнезоидных х-рецепторов - Google Patents
11-гидроксилпроизводные желчных кислот и их аминокислотные конъюгаты в качестве модуляторов фарнезоидных х-рецепторовInfo
- Publication number
- EA201592055A1 EA201592055A1 EA201592055A EA201592055A EA201592055A1 EA 201592055 A1 EA201592055 A1 EA 201592055A1 EA 201592055 A EA201592055 A EA 201592055A EA 201592055 A EA201592055 A EA 201592055A EA 201592055 A1 EA201592055 A1 EA 201592055A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amino acid
- pharnesoid
- receptor modulators
- acid conjugates
- hydroxyl derivatives
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение предусматривает соединение формулы (I) или его фармацевтически приемлемую соль, сольват или аминокислотный конъюгат, где Rпредставляет собой гидроксигруппу, a R, R, R, Rи Rявляются такими, как описано в настоящем документе. Настоящее изобретение, в целом, относится к селективным агонистам FXR и способам их получения и применения.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361823169P | 2013-05-14 | 2013-05-14 | |
| PCT/EP2014/059896 WO2014184271A1 (en) | 2013-05-14 | 2014-05-14 | 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201592055A1 true EA201592055A1 (ru) | 2016-11-30 |
| EA030152B1 EA030152B1 (ru) | 2018-06-29 |
Family
ID=50721801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201592055A EA030152B1 (ru) | 2013-05-14 | 2014-05-14 | 11-гидроксилпроизводные желчных кислот и их аминокислотные конъюгаты в качестве модуляторов фарнезоидных х-рецепторов |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US9611289B2 (ru) |
| EP (4) | EP2997035B8 (ru) |
| JP (2) | JP6326131B2 (ru) |
| KR (1) | KR102229952B1 (ru) |
| CN (2) | CN108245523B (ru) |
| AU (1) | AU2014267324B2 (ru) |
| BR (1) | BR112015028399B1 (ru) |
| CA (1) | CA2912139C (ru) |
| CL (2) | CL2015003344A1 (ru) |
| CR (1) | CR20150643A (ru) |
| CY (1) | CY1122614T1 (ru) |
| DK (4) | DK3360881T3 (ru) |
| EA (1) | EA030152B1 (ru) |
| ES (4) | ES2847002T3 (ru) |
| GT (1) | GT201500324A (ru) |
| HK (2) | HK1253326A1 (ru) |
| HR (1) | HRP20180931T1 (ru) |
| HU (1) | HUE037996T2 (ru) |
| IL (2) | IL242555B (ru) |
| LT (1) | LT2997035T (ru) |
| MA (1) | MA38647B1 (ru) |
| ME (1) | ME03082B (ru) |
| MX (1) | MX352065B (ru) |
| MY (1) | MY187886A (ru) |
| NI (1) | NI201500160A (ru) |
| PE (1) | PE20160665A1 (ru) |
| PH (1) | PH12015502576A1 (ru) |
| PL (3) | PL3360882T3 (ru) |
| PT (3) | PT3360881T (ru) |
| RS (1) | RS57372B1 (ru) |
| SA (1) | SA515370140B1 (ru) |
| SG (1) | SG11201509352XA (ru) |
| SI (3) | SI3360882T1 (ru) |
| TN (1) | TN2015000497A1 (ru) |
| TR (1) | TR201809041T4 (ru) |
| UA (1) | UA118673C2 (ru) |
| WO (1) | WO2014184271A1 (ru) |
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| SI3360882T1 (sl) | 2013-05-14 | 2021-06-30 | Intercept Pharmaceuticals, Inc. | 11-hidroksil-6-substituirani derivati žolčnih kislin in aminokislinski konjugati le-teh kot modulatorji receptorja farnezoid X |
| US10301268B2 (en) | 2014-03-13 | 2019-05-28 | The Salk Institute For Biological Studies | Analogs of fexaramine and methods of making and using |
| US10077268B2 (en) | 2014-03-13 | 2018-09-18 | Salk Institute For Biological Studies | FXR agonists and methods for making and using |
| DK3626725T3 (da) * | 2014-05-29 | 2023-02-27 | Bar Pharmaceuticals S R L | Cholan-derivater til anvendelse ved behandlingen og/eller forebyggelsen af fxr- og tgr5/gpbar1-medierede sygdomme |
| AU2015343025A1 (en) | 2014-11-06 | 2017-06-08 | Enanta Pharmaceuticals, Inc. | Bile acid analogs an FXR/TGR5 agonists and methods of use thereof |
| MX2017006567A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
| DK3221333T3 (da) | 2014-11-19 | 2019-09-30 | Nzp Uk Ltd | 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer |
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| RU2017130466A (ru) | 2015-02-11 | 2019-03-12 | Энанта Фармасьютикалс, Инк. | Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения |
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2014
- 2014-05-14 SI SI201431741T patent/SI3360882T1/sl unknown
- 2014-05-14 DK DK18163622.6T patent/DK3360881T3/da active
- 2014-05-14 EP EP14723820.8A patent/EP2997035B8/en active Active
- 2014-05-14 CA CA2912139A patent/CA2912139C/en active Active
- 2014-05-14 SG SG11201509352XA patent/SG11201509352XA/en unknown
- 2014-05-14 MA MA38647A patent/MA38647B1/fr unknown
- 2014-05-14 EP EP18163622.6A patent/EP3360881B1/en active Active
- 2014-05-14 TR TR2018/09041T patent/TR201809041T4/tr unknown
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- 2014-05-14 DK DK18163623.4T patent/DK3360882T3/da active
- 2014-05-14 DK DK20211780.0T patent/DK3848038T3/da active
- 2014-05-14 UA UAA201511098A patent/UA118673C2/uk unknown
- 2014-05-14 MX MX2015015730A patent/MX352065B/es active IP Right Grant
- 2014-05-14 ES ES18163622T patent/ES2847002T3/es active Active
- 2014-05-14 TN TN2015000497A patent/TN2015000497A1/en unknown
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- 2014-05-14 PL PL18163623T patent/PL3360882T3/pl unknown
- 2014-05-14 EP EP18163623.4A patent/EP3360882B1/en active Active
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- 2014-05-14 AU AU2014267324A patent/AU2014267324B2/en active Active
- 2014-05-14 ES ES14723820.8T patent/ES2671427T3/es active Active
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