EA201591529A1 - Лечение детского дефицита гормона роста человеческими аналогами гормона роста - Google Patents

Лечение детского дефицита гормона роста человеческими аналогами гормона роста

Info

Publication number
EA201591529A1
EA201591529A1 EA201591529A EA201591529A EA201591529A1 EA 201591529 A1 EA201591529 A1 EA 201591529A1 EA 201591529 A EA201591529 A EA 201591529A EA 201591529 A EA201591529 A EA 201591529A EA 201591529 A1 EA201591529 A1 EA 201591529A1
Authority
EA
Eurasian Patent Office
Prior art keywords
growth
hormone
xten
treatment
once
Prior art date
Application number
EA201591529A
Other languages
English (en)
Inventor
Джеффри Л. Клилэнд
Джордж М. Брайт
Эрик Хамфрисс
Original Assignee
Амуникс Оперэйтинг Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Амуникс Оперэйтинг Инк. filed Critical Амуникс Оперэйтинг Инк.
Publication of EA201591529A1 publication Critical patent/EA201591529A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к лечению субъектов детского возраста с детским дефицитом гормона роста (ДДГР). Лечение включает введение пациенту детского возраста с ДДГР химерного белка "гормон роста человека-XTEN" (hGH-XTEN) в терапевтически эффективных дозах раз в неделю, раз в две недели, раз в полмесяца, раз в три недели или раз в месяц. Эта терапия не уступает в достижении скорости роста ежедневным инъекциям hGH, не связанного с XTEN, в течение аналогичного периода.
EA201591529A 2013-03-11 2014-03-10 Лечение детского дефицита гормона роста человеческими аналогами гормона роста EA201591529A1 (ru)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361776618P 2013-03-11 2013-03-11
US201361810786P 2013-04-11 2013-04-11
US201361835002P 2013-06-14 2013-06-14
US201361880701P 2013-09-20 2013-09-20
US201361911731P 2013-12-04 2013-12-04
US201461931987P 2014-01-27 2014-01-27
US201461948457P 2014-03-05 2014-03-05
PCT/US2014/022850 WO2014164568A1 (en) 2013-03-11 2014-03-10 Treatment of pediatric growth hormone deficiency with human growth hormone analogues

Publications (1)

Publication Number Publication Date
EA201591529A1 true EA201591529A1 (ru) 2016-04-29

Family

ID=51658905

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591529A EA201591529A1 (ru) 2013-03-11 2014-03-10 Лечение детского дефицита гормона роста человеческими аналогами гормона роста

Country Status (16)

Country Link
US (1) US20160158321A1 (ru)
EP (1) EP2968451A4 (ru)
JP (3) JP2016514132A (ru)
KR (1) KR20150124955A (ru)
CN (1) CN105209055A (ru)
AU (1) AU2014249258A1 (ru)
BR (1) BR112015022257A8 (ru)
CA (1) CA2900949A1 (ru)
CL (1) CL2015002456A1 (ru)
EA (1) EA201591529A1 (ru)
HK (1) HK1216617A1 (ru)
IL (1) IL240392A0 (ru)
MX (1) MX2015012175A (ru)
PH (1) PH12015502063A1 (ru)
SG (1) SG11201506732YA (ru)
WO (1) WO2014164568A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
WO2016109823A1 (en) * 2015-01-02 2016-07-07 Amunix Operation Inc. Treatment of pediatric growth hormone deficiency with human growth hormone analogues
WO2016124817A1 (en) 2015-02-03 2016-08-11 Beddit Oy Family sleep monitoring system
EP4129327A1 (en) 2015-08-28 2023-02-08 Amunix Pharmaceuticals, Inc. Chimeric polypeptide assembly and methods of making and using the same
WO2017136583A1 (en) 2016-02-02 2017-08-10 Versartis, Inc. Growth hormone treatment adherence system
RU2732113C2 (ru) * 2016-02-17 2020-09-11 Дженексин, Инк. Фармацевтическая композиция, включающая рекомбинантный гормон роста человека для лечения дефицита гормона роста
JOP20190019A1 (ar) * 2016-08-30 2019-02-12 Genexine Inc تركيبة صيدلانية لعلاج نقص في هرمون نمو يحتوي على بروتين اندماجي لهرمون نمو بشري (hGH)
US10288629B1 (en) * 2017-12-19 2019-05-14 Aeterna Zentaris, Inc. Method of assessing growth hormone deficiency in humans by a macimorelin containing composition
RU2753191C2 (ru) * 2019-09-26 2021-08-12 Федеральное государственное бюджетное учреждение науки Институт Биологии Развития им. Н.К. Кольцова Российской Академии Наук Новый рекомбинантный аналог гормона роста пролонгированного действия
EP4085077A4 (en) 2019-12-31 2024-01-17 Beijing QL Biopharmaceutical Co., Ltd. FUSION PROTEINS FROM GLP-1 AND GDF15 AND CONJUGATES THEREOF
WO2021139744A1 (en) 2020-01-11 2021-07-15 Beijing Ql Biopharmaceutical Co., Ltd. Conjugates of fusion proteins of glp-1 and fgf21
KR102599111B1 (ko) * 2020-01-31 2023-11-07 울산대학교 산학협력단 인슐린유사성장인자-1 융합단백질 및 이의 용도
KR102635025B1 (ko) * 2020-07-22 2024-02-07 아에테르나 젠타리스 게엠베하 마시모렐린을 사용하여 소아 환자의 성장 호르몬 결핍증을 진단하는 스크리닝 방법
CN115925994B (zh) 2020-09-30 2023-09-22 北京质肽生物医药科技有限公司 多肽缀合物和使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010091122A1 (en) * 2009-02-03 2010-08-12 Amunix, Inc. Extended recombinant polypeptides and compositions comprising same
WO2011026815A1 (en) * 2009-09-02 2011-03-10 Merck Serono S.A. Compositions and methods for treating growth hormone deficiency
SG11201408152VA (en) * 2012-06-05 2015-01-29 Amunix Operating Inc Hgh-xten fusion protein and its use in the treatment of growth hormone deficiency

Also Published As

Publication number Publication date
BR112015022257A8 (pt) 2018-01-23
PH12015502063A1 (en) 2016-01-25
CN105209055A (zh) 2015-12-30
BR112015022257A2 (pt) 2017-10-10
JP2016514132A (ja) 2016-05-19
MX2015012175A (es) 2016-01-12
JP2019056013A (ja) 2019-04-11
CL2015002456A1 (es) 2016-05-27
AU2014249258A1 (en) 2015-08-27
KR20150124955A (ko) 2015-11-06
CA2900949A1 (en) 2014-10-09
JP2017101074A (ja) 2017-06-08
EP2968451A1 (en) 2016-01-20
SG11201506732YA (en) 2015-09-29
IL240392A0 (en) 2015-09-24
US20160158321A1 (en) 2016-06-09
EP2968451A4 (en) 2017-01-04
HK1216617A1 (zh) 2016-11-25
WO2014164568A1 (en) 2014-10-09

Similar Documents

Publication Publication Date Title
EA201591529A1 (ru) Лечение детского дефицита гормона роста человеческими аналогами гормона роста
BR112015026325A2 (pt) dosagem oral de compostos glp-1
PH12016500296A1 (en) Sodium channel modulators for the treatment of pain and diabetes
NZ703153A (en) Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof
EA201791199A1 (ru) Способ лечения болезни альцгеймера
MX2013011175A (es) Analogos de glucagon novedosos.
ES2397889A1 (es) PÉPTIDOS MODULADORES DE PGC-1Alfa.
BR112014030404A2 (pt) proteína de fusão hgh-xten e seu uso no tratamento da deficiência de hormônio do crescimento
PH12015501931A1 (en) Treatment of diabetes mellitus by long-acting formulations of insulins
BR112014009225A2 (pt) uso de micelas de proteína de soro de leite para crianças pequenas em risco de obesidade ou diabetes
MD20150120A2 (ru) Лечение нейродегенеративных и миопатических заболеваний протеиновой агрегации путём парентерального применения трегалозы
PH12019501363A1 (en) Insulin containing pharmaceutical compositions
EA201691055A1 (ru) Препараты и способы лечения gd2-положительного рака
PH12017500392A1 (en) Medical treatments based on anamorelin
EA201592040A1 (ru) Иммуногенная композиция для применения в терапии
MY193963A (en) Composition for treating joint diseases and kit containing same
WO2016109823A8 (en) Treatment of pediatric growth hormone deficiency with human growth hormone analogues
RU2020120075A (ru) Противомикробная иммуномодуляция
JOP20190019A1 (ar) تركيبة صيدلانية لعلاج نقص في هرمون نمو يحتوي على بروتين اندماجي لهرمون نمو بشري (hGH)
EA201591693A1 (ru) Новые соединения, модулирующие контроль над дыханием, и способы их применения
NZ703729A (en) Combinations with a backbone-cyclized peptide
NZ703723A (en) Combinations with a backbone-cyclized peptide
MX2022007738A (es) Procesos e intermedios sinteticos.
MX2016006375A (es) Una combinacion de unidades de dosificacion para su uso en el tratamiento del parto prematuro.
WO2016115442A3 (en) Therapeutic protein formulations