EA201492206A1 - Рекомбинантные микроорганизмы и их применения - Google Patents

Рекомбинантные микроорганизмы и их применения

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Publication number
EA201492206A1
EA201492206A1 EA201492206A EA201492206A EA201492206A1 EA 201492206 A1 EA201492206 A1 EA 201492206A1 EA 201492206 A EA201492206 A EA 201492206A EA 201492206 A EA201492206 A EA 201492206A EA 201492206 A1 EA201492206 A1 EA 201492206A1
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Eurasian Patent Office
Prior art keywords
terpenes
recombinant microorganisms
methods
microorganisms
pathway
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EA201492206A
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English (en)
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EA028892B1 (ru
Inventor
Венди Чэнь
ФунМинь Лью
Михель Кёпке
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Ланцатек Нью Зилэнд Лимитед
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Application filed by Ланцатек Нью Зилэнд Лимитед filed Critical Ланцатек Нью Зилэнд Лимитед
Publication of EA201492206A1 publication Critical patent/EA201492206A1/ru
Publication of EA028892B1 publication Critical patent/EA028892B1/ru

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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
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    • C12N9/10—Transferases (2.)
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    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
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    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
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    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
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    • C12Y202/01—Transketolases and transaldolases (2.2.1)
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    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
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    • C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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Abstract

Терпены представляют собой ценные коммерческие продукты, используемые в различных отраслях промышленности. Терпены могут быть получены из нефтехимических источников и терпеновых сырьевых материалов, таких как терпентин. Однако указанные способы получения являются дорогостоящими, неприемлыми и часто вызывают экологические проблемы, включая влияние на изменение климата. Микробиологическая ферментация обеспечивает альтернативную возможность получения терпенов. Один или более терпенов и/или их предшественников можно получать путем ферментации микроорганизмами субстрата, содержащего СО. В указанных способах можно применять рекомбинантные микроорганизмы. В указанных способах можно применять карбоксидотрофные ацетогенные рекомбинантные микроорганизмы. Рекомбинантные микроорганизмы могут содержать, например, экзогенные ферменты мевалонатного (MVA) пути и/или DXS-пути.
EA201492206A 2012-06-01 2013-06-04 Способ получения терпенов с помощью рекомбинантных микроорганизмов EA028892B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654412P 2012-06-01 2012-06-01
PCT/NZ2013/000095 WO2013180584A1 (en) 2012-06-01 2013-06-04 Recombinant microorganisms and uses therefor

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EA201492206A1 true EA201492206A1 (ru) 2015-09-30
EA028892B1 EA028892B1 (ru) 2018-01-31

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EA201492206A EA028892B1 (ru) 2012-06-01 2013-06-04 Способ получения терпенов с помощью рекомбинантных микроорганизмов

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US (5) US20130323820A1 (ru)
EP (3) EP3795680A1 (ru)
JP (2) JP6643083B2 (ru)
CN (3) CN104822823B8 (ru)
DK (2) DK2855662T3 (ru)
EA (1) EA028892B1 (ru)
ES (2) ES2674984T3 (ru)
IN (1) IN2014DN10236A (ru)
PL (2) PL3346008T3 (ru)
WO (1) WO2013180584A1 (ru)

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