EA201490901A1 - Линкеры на основе тирозина для свободного соединения пептидов - Google Patents
Линкеры на основе тирозина для свободного соединения пептидовInfo
- Publication number
- EA201490901A1 EA201490901A1 EA201490901A EA201490901A EA201490901A1 EA 201490901 A1 EA201490901 A1 EA 201490901A1 EA 201490901 A EA201490901 A EA 201490901A EA 201490901 A EA201490901 A EA 201490901A EA 201490901 A1 EA201490901 A1 EA 201490901A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tyrosine
- peptide
- free connection
- linkers based
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
- C07C5/02—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Изобретение относится к новым линкерам на основе тирозина, способствующим разъёмному соединению пептидов или белков с другими молекулярными соединениями, например полиэтиленгликолем, способам их получения и их применению для приготовления лекарственных средств для лечения и/или профилактики заболеваний.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11187737 | 2011-11-03 | ||
PCT/EP2012/071373 WO2013064455A1 (en) | 2011-11-03 | 2012-10-29 | Tyrosine based linkers for the releasable connection of peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201490901A1 true EA201490901A1 (ru) | 2014-10-30 |
EA026184B1 EA026184B1 (ru) | 2017-03-31 |
Family
ID=47088883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490901A EA026184B1 (ru) | 2011-11-03 | 2012-10-29 | Линкеры на основе тирозина для свободного соединения пептидов |
Country Status (16)
Country | Link |
---|---|
US (1) | US9315543B2 (ru) |
EP (1) | EP2773375B1 (ru) |
JP (1) | JP6051223B2 (ru) |
KR (1) | KR20150000464A (ru) |
CN (1) | CN104144705B (ru) |
AU (1) | AU2012331279A1 (ru) |
BR (1) | BR112014010806A2 (ru) |
CA (1) | CA2854095C (ru) |
EA (1) | EA026184B1 (ru) |
ES (1) | ES2624626T3 (ru) |
HK (1) | HK1198926A1 (ru) |
IL (1) | IL232152A0 (ru) |
IN (1) | IN2014DN03213A (ru) |
MX (1) | MX2014004953A (ru) |
WO (1) | WO2013064455A1 (ru) |
ZA (1) | ZA201402939B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20190001B1 (ar) * | 2011-11-03 | 2022-03-14 | Bayer Pharma AG | عقار أولي معتمد على جليكول عديد إثيلين من أدرينومدالين واستخدامه |
AU2015323769A1 (en) | 2014-09-26 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Stabilized adrenomedullin derivatives and use thereof |
US11207991B2 (en) * | 2016-12-15 | 2021-12-28 | Ford Global Technologies, Llc | Vehicle charging system for DC fast charging electrified vehicles |
AU2018302022A1 (en) | 2017-07-17 | 2020-02-27 | Macregen, Inc. | Topical delivery of therapeutic agents comprising cell-penetrating peptides for use for the treatment of age-related macular degeneration and other eye diseases |
CN114174326A (zh) | 2019-06-18 | 2022-03-11 | 拜耳公司 | 长期稳定的肾上腺髓质素类似物及其用途 |
CN110591077B (zh) * | 2019-10-17 | 2022-01-07 | 江南大学 | 一种酶催化制备酪氨酸寡肽和接枝单甲氧基聚乙二醇的方法 |
AU2021249447A1 (en) * | 2020-04-03 | 2022-11-03 | Bayer Aktiengesellschaft | Liquid pharmaceutical formulations polyethylene glycol-based prodrugs of adrenomedullin and use |
CN112457218B (zh) * | 2020-11-05 | 2022-08-09 | 宁夏医科大学 | 2,4-二氨基丁酸衍生物的合成方法 |
AU2022330343A1 (en) | 2021-08-20 | 2024-02-08 | Bayer Aktiengesellschaft | Process for the preparation of pegylated adrenomedullin, its intermediates and use thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4812590A (en) | 1987-06-25 | 1989-03-14 | Merck & Co., Inc. | Carbamates of 4-hydroxyanisole as prodrugs for chemotherapy of melanoma |
US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
US8877901B2 (en) * | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
WO2004019993A1 (en) | 2002-08-30 | 2004-03-11 | Ramot At Tel Aviv University Ltd. | Self-immolative dendrimers releasing many active moieties upon a single activating event |
US7705045B2 (en) | 2002-11-14 | 2010-04-27 | Syntarga, B.V. | Prodrugs built as multiple self-elimination-release spacers |
AU2005232371B2 (en) | 2004-03-23 | 2010-10-14 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
WO2005097162A2 (en) * | 2004-04-01 | 2005-10-20 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and their use |
GB2427360A (en) | 2005-06-22 | 2006-12-27 | Complex Biosystems Gmbh | Aliphatic prodrug linker |
US8273325B2 (en) * | 2006-12-20 | 2012-09-25 | Ge Healthcare As | Contrast agents |
CN101641119A (zh) * | 2006-12-20 | 2010-02-03 | 通用电气医疗集团股份有限公司 | 造影剂 |
WO2009092071A2 (en) * | 2008-01-18 | 2009-07-23 | Shire Llc | Amino acid and peptide pro-drugs of phenolic analgesics and uses thereof |
LT2459220T (lt) * | 2009-07-31 | 2020-12-28 | Ascendis Pharma A/S | Biologiškai suyrantys vandenyje netirpūs hidrogeliai polietilenglikolio pagrindu |
JOP20190001B1 (ar) * | 2011-11-03 | 2022-03-14 | Bayer Pharma AG | عقار أولي معتمد على جليكول عديد إثيلين من أدرينومدالين واستخدامه |
-
2012
- 2012-10-29 JP JP2014539300A patent/JP6051223B2/ja active Active
- 2012-10-29 CN CN201280065842.4A patent/CN104144705B/zh active Active
- 2012-10-29 ES ES12779063.2T patent/ES2624626T3/es active Active
- 2012-10-29 AU AU2012331279A patent/AU2012331279A1/en not_active Abandoned
- 2012-10-29 US US14/355,836 patent/US9315543B2/en active Active
- 2012-10-29 MX MX2014004953A patent/MX2014004953A/es unknown
- 2012-10-29 WO PCT/EP2012/071373 patent/WO2013064455A1/en active Application Filing
- 2012-10-29 BR BR112014010806A patent/BR112014010806A2/pt not_active IP Right Cessation
- 2012-10-29 KR KR1020147014503A patent/KR20150000464A/ko not_active Application Discontinuation
- 2012-10-29 EP EP12779063.2A patent/EP2773375B1/en active Active
- 2012-10-29 IN IN3213DEN2014 patent/IN2014DN03213A/en unknown
- 2012-10-29 EA EA201490901A patent/EA026184B1/ru not_active IP Right Cessation
- 2012-10-29 CA CA2854095A patent/CA2854095C/en active Active
-
2014
- 2014-04-22 IL IL232152A patent/IL232152A0/en unknown
- 2014-04-23 ZA ZA2014/02939A patent/ZA201402939B/en unknown
- 2014-12-12 HK HK14112488.8A patent/HK1198926A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR20150000464A (ko) | 2015-01-02 |
ZA201402939B (en) | 2015-11-25 |
CA2854095A1 (en) | 2013-05-10 |
EP2773375A1 (en) | 2014-09-10 |
IN2014DN03213A (ru) | 2015-05-22 |
EP2773375B1 (en) | 2017-02-08 |
JP2014533244A (ja) | 2014-12-11 |
US20150051160A1 (en) | 2015-02-19 |
JP6051223B2 (ja) | 2016-12-27 |
AU2012331279A1 (en) | 2014-05-08 |
BR112014010806A2 (pt) | 2017-05-02 |
CN104144705A (zh) | 2014-11-12 |
US9315543B2 (en) | 2016-04-19 |
WO2013064455A1 (en) | 2013-05-10 |
ES2624626T3 (es) | 2017-07-17 |
HK1198926A1 (en) | 2015-06-19 |
CN104144705B (zh) | 2017-03-01 |
MX2014004953A (es) | 2014-05-28 |
EA026184B1 (ru) | 2017-03-31 |
CA2854095C (en) | 2021-03-30 |
IL232152A0 (en) | 2014-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201490901A1 (ru) | Линкеры на основе тирозина для свободного соединения пептидов | |
EA201270722A1 (ru) | Формы рифаксимина и их применение | |
MX2018013981A (es) | Productos farmaceuticos peptidicos mejorados para la resistencia a la insulina. | |
MX2019003716A (es) | Formulaciones farmaceuticas de anticuerpos tnf-alfa. | |
TW201613958A (en) | MIC-1 fusion proteins and uses thereof | |
EA201171494A1 (ru) | Миметики белка smac | |
MX2023010178A (es) | Conjugados de anticuerpo farmaco anti-cd70. | |
EA201390821A1 (ru) | Антагонисты рецепторов лизофосфатидной кислоты и их применение | |
MX344219B (es) | Productos farmaceuticos peptidicos mejorados para resistencia a insulina. | |
EA201391719A1 (ru) | Хиназолиновые производные для лечения вирусных инфекций и дальнейших заболеваний | |
EA201291336A1 (ru) | Замещенные 5-фтор-1н-пиразолопиридины и их применение | |
EA201591166A1 (ru) | Ингибиторы аутотаксина | |
CA2796215C (en) | Compositions and methods for brain delivery of analgesic peptides | |
UA118167C2 (uk) | Пептид та його застосування | |
EA201390803A1 (ru) | Ингибиторы бромодомена и их применение | |
EA201491423A1 (ru) | Соединения имидазопирролидинонов | |
EA201370178A1 (ru) | Стабильные составы для парентеральной инъекции пептидных лекарственных средств | |
EA201391175A1 (ru) | Гетеродимерные иммуноглобулины | |
WO2012040459A3 (en) | Beta-catenin targeting peptides and uses thereof | |
EA201170441A1 (ru) | Терапевтические противовирусные пептиды | |
EP4286400A3 (en) | Improved peptide pharmaceuticals | |
EA201200515A1 (ru) | Полипептиды и их применение | |
EA201390669A1 (ru) | Способы и композиции для иммунотерапии заболеваний нервной системы | |
UA111098C2 (uk) | Проліки адреномедуліну на основі поліетиленгліколю і їх застосування | |
EA201301107A1 (ru) | Моноклональные антитела против ингибитора пути тканевого фактора (tfpi) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM RU |