EA201490640A1 - Замещенные 4,5,6,7-тетрагидро-1h-пиразоло[4,3-c]пиридины, их применение в качестве лекарственного средства и фармацевтические препараты, содержащие их - Google Patents

Замещенные 4,5,6,7-тетрагидро-1h-пиразоло[4,3-c]пиридины, их применение в качестве лекарственного средства и фармацевтические препараты, содержащие их

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Publication number
EA201490640A1
EA201490640A1 EA201490640A EA201490640A EA201490640A1 EA 201490640 A1 EA201490640 A1 EA 201490640A1 EA 201490640 A EA201490640 A EA 201490640A EA 201490640 A EA201490640 A EA 201490640A EA 201490640 A1 EA201490640 A1 EA 201490640A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolo
tetrahydro
medicine
substituted
pharmaceutical preparations
Prior art date
Application number
EA201490640A
Other languages
English (en)
Other versions
EA025240B1 (ru
Inventor
Лоран Биали
Катрин Лоренц
Клаус Вирт
Клаус Штайнмейер
Герхард Хесслер
Йозеф Пернершторфер
Йоахим Брендель
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of EA201490640A1 publication Critical patent/EA201490640A1/ru
Publication of EA025240B1 publication Critical patent/EA025240B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к замещенным 4,5,6,7-тетрагидро-1Н-пиразоло[4,3-c]пиридинам формулы (I), их применению в качестве лекарственного средства и содержащим их фармацевтическим препаратам. Соединения формулы (I) действуют на калиевый канал TASK-1. Соединения подходят для лечения или предупреждения предсердных аритмий, например предсердной фибрилляции (ПФ) или предсердного трепетания.
EA201490640A 2011-09-16 2012-09-13 ЗАМЕЩЕННЫЕ 4,5,6,7-ТЕТРАГИДРО-1H-ПИРАЗОЛО[4,3-c]ПИРИДИНЫ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННОГО СРЕДСТВА И ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ, СОДЕРЖАЩИЕ ИХ EA025240B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11306161 2011-09-16
PCT/EP2012/067995 WO2013037914A1 (en) 2011-09-16 2012-09-13 Substituted 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them

Publications (2)

Publication Number Publication Date
EA201490640A1 true EA201490640A1 (ru) 2014-09-30
EA025240B1 EA025240B1 (ru) 2016-12-30

Family

ID=46832425

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490640A EA025240B1 (ru) 2011-09-16 2012-09-13 ЗАМЕЩЕННЫЕ 4,5,6,7-ТЕТРАГИДРО-1H-ПИРАЗОЛО[4,3-c]ПИРИДИНЫ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННОГО СРЕДСТВА И ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ, СОДЕРЖАЩИЕ ИХ

Country Status (4)

Country Link
BR (1) BR112014006180A2 (ru)
EA (1) EA025240B1 (ru)
MX (1) MX2014003181A (ru)
WO (1) WO2013037914A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3134406A1 (en) * 2014-04-24 2017-03-01 Dart Neuroscience (Cayman) Ltd Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c]pyridine compounds as glyt1 inhibitors
US10040759B2 (en) 2014-11-05 2018-08-07 Dart Neuroscience (Cayman) Ltd. Substituted azetidinyl compounds as GlyT1 inhibitors
JP6713465B2 (ja) * 2014-12-30 2020-06-24 ノヴィラ・セラピューティクス・インコーポレイテッド Ｂ型肝炎感染症治療のための誘導体及び方法
JP2018536693A (ja) * 2015-12-10 2018-12-13 バイエル・ファルマ・アクティエンゲゼルシャフト 睡眠関連呼吸障害を治療するためのＴＡＳＫ−１およびＴＡＳＫ−２チャネルの遮断薬としての２−フェニル−３−（ピペラジノメチル）イミダゾ［１，２−ａ］ピリジン誘導体
US10414765B2 (en) 2015-12-10 2019-09-17 Bayer Pharma Aktiengesellschaft Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same
JOP20190284A1 (ar) * 2017-06-14 2019-12-11 Bayer Pharma AG مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس
US20230271957A1 (en) * 2020-04-09 2023-08-31 Disarm Therapeutics, Inc. Condensed pyrazole derivatives as inhibitors of sarm1
GB202101734D0 (en) * 2021-02-08 2021-03-24 Cerevance Inc Novel Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK27383A (da) 1982-02-17 1983-08-18 Lepetit Spa Fremgangsmaade til fremstilling af pyrazol(4,3-c)pyridiner
DE10332685A1 (de) 2003-07-18 2005-02-17 Bayer Healthcare Ag Vorhof-selektiv exprimierte Kaliumkanäle
DE102005028862A1 (de) 2005-06-22 2007-01-11 Sanofi-Aventis Deutschland Gmbh Substituierte Heterocyclen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE102005028845A1 (de) * 2005-06-22 2006-12-28 Sanofi-Aventis Deutschland Gmbh Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
AU2007245891B2 (en) 2006-04-27 2012-10-18 Sanofi-Aventis Deutschland Gmbh Inhibitors of the TASK-1 and TASK-3 ion channel
WO2011115804A1 (en) * 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators

Also Published As

Publication number Publication date
BR112014006180A2 (pt) 2017-04-11
EA025240B1 (ru) 2016-12-30
WO2013037914A1 (en) 2013-03-21
MX2014003181A (es) 2015-08-05

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU