EA201401272A1 - Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и парацетамол или пропацетамол - Google Patents

Фармацевтическая композиция, содержащая (1r,4r)-6'-фтор-n,n-диметил-4-фенил-4',9'-дигидро-3'h-спиро[циклогексан-1,1'-пирано-[3,4,b]индол]-4-амин и парацетамол или пропацетамол

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Publication number
EA201401272A1
EA201401272A1 EA201401272A EA201401272A EA201401272A1 EA 201401272 A1 EA201401272 A1 EA 201401272A1 EA 201401272 A EA201401272 A EA 201401272A EA 201401272 A EA201401272 A EA 201401272A EA 201401272 A1 EA201401272 A1 EA 201401272A1
Authority
EA
Eurasian Patent Office
Prior art keywords
propacetamol
paracetamol
spiro
dihydro
fluoro
Prior art date
Application number
EA201401272A
Other languages
English (en)
Other versions
EA026949B1 (ru
Inventor
Штефани Фрош
Клаус Линц
Клаус Шине
Original Assignee
Грюненталь Гмбх
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Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201401272A1 publication Critical patent/EA201401272A1/ru
Publication of EA026949B1 publication Critical patent/EA026949B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к фармацевтической композиции, содержащей первый фармакологически активный ингредиент, выбранный из (1R,4R)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4,b]индол]-4-амина и его физиологически приемлемых солей, и второй фармакологически активный ингредиент, выбранный из парацетамола и пропацетамола.
EA201401272A 2012-05-18 2013-05-16 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО-[3,4,b]ИНДОЛ]-4-АМИН И ПАРАЦЕТАМОЛ ИЛИ ПРОПАЦЕТАМОЛ EA026949B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12003897 2012-05-18
PCT/EP2013/001468 WO2013170969A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol

Publications (2)

Publication Number Publication Date
EA201401272A1 true EA201401272A1 (ru) 2015-05-29
EA026949B1 EA026949B1 (ru) 2017-06-30

Family

ID=48468208

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201401272A EA026949B1 (ru) 2012-05-18 2013-05-16 ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ (1r,4r)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'H-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО-[3,4,b]ИНДОЛ]-4-АМИН И ПАРАЦЕТАМОЛ ИЛИ ПРОПАЦЕТАМОЛ

Country Status (23)

Country Link
US (3) US20130310435A1 (ru)
EP (1) EP2849740B1 (ru)
JP (1) JP6116676B2 (ru)
CN (2) CN108524498A (ru)
AU (1) AU2013262075B2 (ru)
BR (1) BR112014028561A2 (ru)
CA (1) CA2873644A1 (ru)
CY (1) CY1119610T1 (ru)
DK (1) DK2849740T3 (ru)
EA (1) EA026949B1 (ru)
ES (1) ES2650441T3 (ru)
HK (1) HK1204940A1 (ru)
HR (1) HRP20171438T1 (ru)
HU (1) HUE034676T2 (ru)
IL (1) IL235651B (ru)
LT (1) LT2849740T (ru)
MX (1) MX352596B (ru)
NO (1) NO2849740T3 (ru)
PL (1) PL2849740T3 (ru)
PT (1) PT2849740T (ru)
RS (1) RS56617B1 (ru)
SI (1) SI2849740T1 (ru)
WO (1) WO2013170969A1 (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017009416A (es) 2015-01-23 2017-10-12 Gruenenthal Gmbh Cebranopadol para tratar el dolor en sujetos con insuficiencia hepatica o renal.

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Also Published As

Publication number Publication date
DK2849740T3 (da) 2017-11-20
US20130310435A1 (en) 2013-11-21
EP2849740A1 (en) 2015-03-25
PT2849740T (pt) 2017-12-13
RS56617B1 (sr) 2018-02-28
AU2013262075A1 (en) 2015-01-22
US20190350884A1 (en) 2019-11-21
JP6116676B2 (ja) 2017-04-19
CA2873644A1 (en) 2013-11-21
HK1204940A1 (en) 2015-12-11
CN104302282A (zh) 2015-01-21
CY1119610T1 (el) 2018-04-04
MX352596B (es) 2017-11-30
MX2014012723A (es) 2015-01-15
CN108524498A (zh) 2018-09-14
NO2849740T3 (ru) 2018-02-10
EA026949B1 (ru) 2017-06-30
EP2849740B1 (en) 2017-09-13
LT2849740T (lt) 2017-12-27
WO2013170969A1 (en) 2013-11-21
BR112014028561A2 (pt) 2017-07-25
PL2849740T3 (pl) 2018-03-30
US20180092867A1 (en) 2018-04-05
IL235651B (en) 2018-08-30
US11311504B2 (en) 2022-04-26
IL235651A0 (en) 2015-01-29
HUE034676T2 (hu) 2018-02-28
ES2650441T3 (es) 2018-01-18
HRP20171438T1 (hr) 2017-11-03
JP2015516449A (ja) 2015-06-11
AU2013262075B2 (en) 2017-10-26
SI2849740T1 (en) 2018-01-31

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