EA201400685A1 - Solid Forms of Hydrochloride [3,4, B] INDOL] -4-AMINA - Google Patents

Solid Forms of Hydrochloride [3,4, B] INDOL] -4-AMINA

Info

Publication number
EA201400685A1
EA201400685A1 EA201400685A EA201400685A EA201400685A1 EA 201400685 A1 EA201400685 A1 EA 201400685A1 EA 201400685 A EA201400685 A EA 201400685A EA 201400685 A EA201400685 A EA 201400685A EA 201400685 A1 EA201400685 A1 EA 201400685A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solid forms
amina
indol
hydrochloride
forms
Prior art date
Application number
EA201400685A
Other languages
Russian (ru)
Other versions
EA032462B1 (en
Inventor
Штефан Клуге
Михаэль Грусс
Андреас Зибер
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201400685A1 publication Critical patent/EA201400685A1/en
Publication of EA032462B1 publication Critical patent/EA032462B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к твердым формам гидрохлорида (1r,4r)-6'-фтор-N,N-диметил-4-фенил-4',9'-дигидро-3'Н-спиро[циклогексан-1,1'-пирано[3,4b]индол]-4-амина, в частности их кристаллическим и/или аморфным формам, фармацевтическим композициям и лекарственным средствам, содержащим эти твердые формы, к способу использования этих твердых форм, а также к способу их получения.The invention relates to solid forms of (1r, 4r) -6'-fluoro-N, N-dimethyl-4-phenyl-4 ', 9'-dihydro-3'H-spiro [cyclohexane-1,1'-pyrano [ 3,4b] indole] -4-amine, in particular their crystalline and / or amorphous forms, pharmaceutical compositions and medicines containing these solid forms, to the method of using these solid forms, as well as to the method for their preparation.

EA201400685A 2011-12-12 2012-12-11 SOLID FORMS OF (1r,4r)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4b]INDOL]-4-AMINE HYDROCHLORIDE EA032462B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11009773 2011-12-12
PCT/EP2012/075003 WO2013087590A1 (en) 2011-12-12 2012-12-11 Solid forms of (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine hydrochloride

Publications (2)

Publication Number Publication Date
EA201400685A1 true EA201400685A1 (en) 2014-12-30
EA032462B1 EA032462B1 (en) 2019-05-31

Family

ID=47324170

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400685A EA032462B1 (en) 2011-12-12 2012-12-11 SOLID FORMS OF (1r,4r)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4b]INDOL]-4-AMINE HYDROCHLORIDE

Country Status (24)

Country Link
US (1) US8895604B2 (en)
EP (1) EP2797923B1 (en)
JP (1) JP6276702B2 (en)
CN (2) CN106432256B (en)
AR (1) AR089145A1 (en)
AU (1) AU2012350762B2 (en)
BR (1) BR112014014202A2 (en)
CA (1) CA2858762C (en)
CY (1) CY1118132T1 (en)
DK (1) DK2797923T3 (en)
EA (1) EA032462B1 (en)
ES (1) ES2605786T3 (en)
HK (1) HK1199258A1 (en)
HR (1) HRP20161283T1 (en)
HU (1) HUE029406T2 (en)
IL (1) IL233048A0 (en)
LT (1) LT2797923T (en)
MX (1) MX353331B (en)
PL (1) PL2797923T3 (en)
PT (1) PT2797923T (en)
RS (1) RS55296B1 (en)
SI (1) SI2797923T1 (en)
TW (1) TWI567077B (en)
WO (1) WO2013087590A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018213606A1 (en) * 2018-08-13 2020-02-13 Zf Friedrichshafen Ag Joint and method of making such a joint

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (en) * 2002-11-11 2004-05-27 Grünenthal GmbH New spiro-((cyclohexane)-tetrahydropyrano-(3,4-b)-indole) derivatives, are ORL1 receptor ligands useful e.g. for treating anxiety, depression, epilepsy, senile dementia, withdrawal symptoms or especially pain
DE102006046745A1 (en) 2006-09-29 2008-04-03 Grünenthal GmbH Use of spirocyclic cyclohexane-derivative exhibiting an affinity for opioid-receptor and opioid receptor-like-1-receptor, for producing a medicament e.g. for treating diabetic neuropathy, for narcosis or for analgesia during narcosis
MX2010009955A (en) * 2008-03-27 2010-09-30 Gruenenthal Gmbh Substituted spirocyclic cyclohexane derivatives.
BR112013002696A2 (en) * 2010-08-04 2016-05-31 Gruenenthal Gmbh pharmaceutical dosage form comprising 6'-fluor- (n-methyl- or n, n-dimethyl-) 4-phenyl-4 ', 9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyran [3,4-b] indole] -4 amine 13 ''
SI2600838T1 (en) * 2010-08-04 2015-12-31 Gruenenthal Gmbh Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro(cyclohexane-1,1'-pyrano(3,4,b)indol)-4-amine

Also Published As

Publication number Publication date
CA2858762C (en) 2017-10-17
IL233048A0 (en) 2014-07-31
MX353331B (en) 2018-01-09
AR089145A1 (en) 2014-07-30
TWI567077B (en) 2017-01-21
CN104105699B (en) 2016-08-24
JP2015500310A (en) 2015-01-05
CN104105699A (en) 2014-10-15
CN106432256B (en) 2019-08-09
SI2797923T1 (en) 2016-12-30
US8895604B2 (en) 2014-11-25
HK1199258A1 (en) 2015-06-26
US20130150420A1 (en) 2013-06-13
CY1118132T1 (en) 2017-06-28
JP6276702B2 (en) 2018-02-07
AU2012350762A1 (en) 2014-07-17
MX2014007009A (en) 2014-07-14
EP2797923B1 (en) 2016-09-07
RS55296B1 (en) 2017-03-31
LT2797923T (en) 2016-12-12
PT2797923T (en) 2016-12-15
HUE029406T2 (en) 2017-03-28
HRP20161283T1 (en) 2016-11-18
BR112014014202A2 (en) 2017-06-13
ES2605786T3 (en) 2017-03-16
TW201331205A (en) 2013-08-01
AU2012350762B2 (en) 2017-03-30
WO2013087590A1 (en) 2013-06-20
EA032462B1 (en) 2019-05-31
DK2797923T3 (en) 2016-12-19
PL2797923T3 (en) 2017-07-31
CN106432256A (en) 2017-02-22
EP2797923A1 (en) 2014-11-05
CA2858762A1 (en) 2013-06-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU