EA201370060A1 - CLATRIC COMPLEXES β-CYCLODEXTRIN WITH 1 - {[6-BROM-1-OPH-4-METHOXI-2-FENYL-TOMETHYL-1-AP-4-BENIL-3-FENILTIOMETHYL-1-N-INDYL-3-PHENYLETIOMETHYL-1-N-INDOL-3-BIO-2-FENYLETIOMETHYL-1-N-INDYL-3-BETCH APPLICATION - Google Patents

CLATRIC COMPLEXES β-CYCLODEXTRIN WITH 1 - {[6-BROM-1-OPH-4-METHOXI-2-FENYL-TOMETHYL-1-AP-4-BENIL-3-FENILTIOMETHYL-1-N-INDYL-3-PHENYLETIOMETHYL-1-N-INDOL-3-BIO-2-FENYLETIOMETHYL-1-N-INDYL-3-BETCH APPLICATION

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Publication number
EA201370060A1
EA201370060A1 EA201370060A EA201370060A EA201370060A1 EA 201370060 A1 EA201370060 A1 EA 201370060A1 EA 201370060 A EA201370060 A EA 201370060A EA 201370060 A EA201370060 A EA 201370060A EA 201370060 A1 EA201370060 A1 EA 201370060A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indyl
cyclodextrin
phenyletiomethyl
fenyletiomethyl
feniltiomethyl
Prior art date
Application number
EA201370060A
Other languages
Russian (ru)
Other versions
EA022693B1 (en
Inventor
Илья Владимирович ВОРОБЬЁВ
Виктор Владимирович ХОМИЧЁНОК
Владимир Константинович ПОДГОРОДНИЧЕНКО
Анатолий Федорович ЦЫБ
Рахимджан Ахметджанович РОЗИЕВ
Анна Яковлевна ГОНЧАРОВА
Original Assignee
Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания" Медбиофарм"
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Publication date
Application filed by Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания" Медбиофарм" filed Critical Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания" Медбиофарм"
Publication of EA201370060A1 publication Critical patent/EA201370060A1/en
Publication of EA022693B1 publication Critical patent/EA022693B1/en

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Изобретение относится к новому клатратному комплексу β-циклодекстрина с 1-{[6-бром-1-метил-5-метокси-2-фенилтиометил-1-Н-индол-3-ил]карбонил}-4-бензилпиперазином формулы (1)при мольном соотношении производные 1-{[6-бром-1-метил-5-метокси-2-фенилтиометил-1-Н-индол-3-ил]карбонил}-4-бензилпиперазин:β-циклодекстрин от 1:1 до 1:10. Изобретение также описывает твердофазный и жидкофазный способы получения и применения указанного клатратного комплекса.The invention relates to a new β-cyclodextrin clathrate complex with 1 - {[6-bromo-1-methyl-5-methoxy-2-phenylthiomethyl-1-H-indole-3-yl] carbonyl} -4-benzylpiperazine of formula (1) when the molar ratio of the derivatives of 1 - {[6-bromo-1-methyl-5-methoxy-2-phenylthiomethyl-1-H-indole-3-yl] carbonyl} -4-benzylpiperazine: β-cyclodextrin from 1: 1 to 1 :ten. The invention also describes solid-phase and liquid-phase methods for the preparation and use of said clathrate complex.

EA201370060A 2010-11-01 2011-10-31 CLATHRATE COMPLEXES OF β-CYCLODEXTRIN WITH 1-{[6-BROMO-1-METHYL-5-METHOXY-2-PHENYLTHIOMETHYL-1H-INDOLE-3-YL]CARBONYL}-4-BENZYLPIPERAZINE HAVING ANTIVIRAL ACTIVITY, THE PRODUCTION AND USE THEREOF EA022693B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2010144371/04A RU2448120C1 (en) 2010-11-01 2010-11-01 Clathrate complexes of beta-cyclodextrin with 1-{[6-bromo-1-methyl-5-methoxy-2-phenylthiomethyl-1-h-indol-3-yl]carbonyl}-4-benzylpiperazine, having antiviral activity, synthesis and use thereof
PCT/RU2011/000841 WO2012060738A1 (en) 2010-11-01 2011-10-31 CLATHRATE COMPLEXES OF β-CYCLODEXTRIN WITH 1-{[6-BROMO-1-METHYL-5-METHOXY-2-PHENYLTHIOMETHYL-1-H-INDOLE-3-YL]CARBONYL}-4-BENZYLPIPERAZINE HAVING ANTIVIRAL ACTIVITY, THE PRODUCTION AND USE THEREOF

Publications (2)

Publication Number Publication Date
EA201370060A1 true EA201370060A1 (en) 2013-11-29
EA022693B1 EA022693B1 (en) 2016-02-29

Family

ID=46024679

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201370060A EA022693B1 (en) 2010-11-01 2011-10-31 CLATHRATE COMPLEXES OF β-CYCLODEXTRIN WITH 1-{[6-BROMO-1-METHYL-5-METHOXY-2-PHENYLTHIOMETHYL-1H-INDOLE-3-YL]CARBONYL}-4-BENZYLPIPERAZINE HAVING ANTIVIRAL ACTIVITY, THE PRODUCTION AND USE THEREOF

Country Status (3)

Country Link
EA (1) EA022693B1 (en)
RU (1) RU2448120C1 (en)
WO (1) WO2012060738A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019203697A1 (en) * 2018-04-19 2019-10-24 Рахимджан Ахметджанович РОЗИЕВ Composition for treating viral diseases (variants)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2572334C2 (en) * 2013-12-06 2016-01-10 Общество С Ограниченной Ответственностью "Луфатен" Clathrate complex of arabinogalactan or arabic gum with 20-hydroxyecdysones, method for producing it (versions), pharmaceutical composition and medicinal product
RU2640081C1 (en) * 2016-07-11 2017-12-26 Общество с ограниченной ответственностью "ЛАЙФ САЙНСЕС ОХФК" Pharmaceutical composition and medicinal product based on clathrate complex of n-carbamoylmethyl-4-phenyl-2-pyrrolidone, or 4-phenylpyracetam with cyclodextrin, method for production (versions)
IT201600075246A1 (en) * 2016-07-19 2018-01-19 Jointherapeutics S R L Compositions comprising a polysaccharide matrix for the controlled release of active principles.
RU2678769C2 (en) * 2016-09-02 2019-02-01 Общество с ограниченной ответственностью "Тиацен" Solution that have antiproliferative and antimetastatic properties for oncological diseases treatment
RU2761429C2 (en) * 2018-06-13 2021-12-08 Общество с ограниченной ответственностью "Тиацен" Remedy with anti-tumor effect for treatment of oncological diseases
RU2741848C1 (en) * 2019-03-16 2021-01-29 Иванова Мария Ивановна Method of producing clathrate complexes of volatile substances

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190818B (en) * 1982-11-09 1986-11-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing complexes of piperonyl-butoxide-cyclodextrin
US4727064A (en) * 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
RU2128664C1 (en) * 1996-08-14 1999-04-10 Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" Inclusion compound of 9-(2-hydroxyethoxymethyl)guanine with beta- cyclodextrine manifesting antiherpes activity
RU2387642C2 (en) * 2007-10-31 2010-04-27 Общество С Ограниченной Ответственностью "Бинатех" 5-substituted indole-3-carboxylic acid derivatives, having antiviral activity, synthesis method thereof and use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019203697A1 (en) * 2018-04-19 2019-10-24 Рахимджан Ахметджанович РОЗИЕВ Composition for treating viral diseases (variants)

Also Published As

Publication number Publication date
RU2448120C1 (en) 2012-04-20
EA022693B1 (en) 2016-02-29
WO2012060738A1 (en) 2012-05-10

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU