EA201300688A1 - Новая форма введения ингибитора энкефалиназы - Google Patents

Новая форма введения ингибитора энкефалиназы

Info

Publication number
EA201300688A1
EA201300688A1 EA201300688A EA201300688A EA201300688A1 EA 201300688 A1 EA201300688 A1 EA 201300688A1 EA 201300688 A EA201300688 A EA 201300688A EA 201300688 A EA201300688 A EA 201300688A EA 201300688 A1 EA201300688 A1 EA 201300688A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitor
enechalinase
introduction
new form
new
Prior art date
Application number
EA201300688A
Other languages
English (en)
Other versions
EA022730B1 (ru
Inventor
Жан-Стефан Жюльен
Марк Мори
Жанн-Мари Лёкомт
Ксавье Линьо
Филипп Робер
Жан-Шарль Шварц
Original Assignee
Биопроже
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Биопроже filed Critical Биопроже
Publication of EA201300688A1 publication Critical patent/EA201300688A1/ru
Publication of EA022730B1 publication Critical patent/EA022730B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к новому составу ингибитора энкефалиназы, такому как рацекадотрил или дексекадотрил, к способу его получения и к его применению при лечении диарреи.
EA201300688A 2010-12-10 2011-12-09 Новая форма введения ингибитора энкефалиназы EA022730B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10306397A EP2462922A1 (en) 2010-12-10 2010-12-10 New form of administration of enkephalinase inhibitor
PCT/EP2011/072315 WO2012076691A1 (en) 2010-12-10 2011-12-09 New form of administration of enkephalinase inhibitor

Publications (2)

Publication Number Publication Date
EA201300688A1 true EA201300688A1 (ru) 2014-11-28
EA022730B1 EA022730B1 (ru) 2016-02-29

Family

ID=45092498

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300688A EA022730B1 (ru) 2010-12-10 2011-12-09 Новая форма введения ингибитора энкефалиназы

Country Status (31)

Country Link
US (1) US9439853B2 (ru)
EP (2) EP2462922A1 (ru)
JP (1) JP5847192B2 (ru)
KR (1) KR101837685B1 (ru)
CN (1) CN103338749B (ru)
AP (1) AP3787A (ru)
AU (1) AU2011340500B2 (ru)
BR (1) BR112013014388A2 (ru)
CA (1) CA2820835C (ru)
CO (1) CO6731092A2 (ru)
CY (1) CY1123056T1 (ru)
DK (1) DK2648696T3 (ru)
EA (1) EA022730B1 (ru)
EC (1) ECSP13012665A (ru)
ES (1) ES2791710T3 (ru)
HR (1) HRP20200555T1 (ru)
HU (1) HUE049273T2 (ru)
IL (1) IL226775A (ru)
LT (1) LT2648696T (ru)
MA (1) MA34724B1 (ru)
ME (1) ME03769B (ru)
MX (1) MX354858B (ru)
NZ (1) NZ611597A (ru)
PL (1) PL2648696T3 (ru)
PT (1) PT2648696T (ru)
RS (1) RS60197B1 (ru)
SG (1) SG191068A1 (ru)
SI (1) SI2648696T1 (ru)
TN (1) TN2013000239A1 (ru)
UA (1) UA111835C2 (ru)
WO (1) WO2012076691A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2987268B1 (fr) * 2012-02-28 2014-07-11 Ammtek Formulations liquides de sulfamides hypoglycemiants
US9801819B2 (en) * 2012-06-28 2017-10-31 Johnson & Johnson Consumer Inc. Racecadotril compositions
US9114171B2 (en) * 2012-06-28 2015-08-25 Mcneil-Ppc, Inc. Racecadotril liquid compositions
MX2015000215A (es) * 2012-06-28 2015-04-10 Mcneil Ppc Inc Composiciones liquidas de racecadotrilo.
KR20150023876A (ko) * 2012-06-28 2015-03-05 맥네일-피피씨, 인코포레이티드 라세카도트릴 지질 조성물
CN105848643A (zh) * 2013-12-23 2016-08-10 强生消费者公司 消旋卡多曲组合物
MA39009A (fr) 2014-03-10 2015-09-16 Galenicum Health Sl Compositions pharmaceutiques comprenant un agent actif
EP2949318A1 (en) 2014-05-26 2015-12-02 Galenicum Health S.L. Pharmaceutical compositions comprising racecadotril
MA40859A (fr) 2014-10-29 2017-09-05 Johnson & Johnson Consumer Inc Particules de cadotril
CN105125477A (zh) * 2015-08-19 2015-12-09 黑龙江佰彤儿童药物研究有限公司 一种含消旋卡多曲的药物制剂及制备方法
IT201700099690A1 (it) * 2017-09-06 2019-03-06 Abiogen Pharma Spa Composizione per l’integrazione di calcio

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
GB0015490D0 (en) * 2000-06-23 2000-08-16 Smithkline Beecham Lab Novel formulations
DE60112756T2 (de) 2000-06-23 2006-06-08 Bioprojet Racecadotril enthaltende trockene pulverformulierung
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
EP1563848A1 (en) * 2004-02-12 2005-08-17 Bioprojet New combinations of an anti-emetic agent and an enkephalinase inhibitor
WO2007102171A2 (en) * 2006-03-07 2007-09-13 Panacea Biotec Ltd Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition
CN101103960B (zh) * 2006-07-14 2010-12-08 海南盛科生命科学研究院 一种含有消旋卡多曲的干混悬剂及其制备方法
TW201014830A (en) * 2008-09-30 2010-04-16 Theravance Inc Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid

Also Published As

Publication number Publication date
ME03769B (me) 2021-04-20
TN2013000239A1 (en) 2014-11-10
CA2820835C (en) 2019-01-08
CA2820835A1 (en) 2012-06-14
US20130331423A1 (en) 2013-12-12
MA34724B1 (fr) 2013-12-03
AU2011340500B2 (en) 2016-10-20
MX2013006492A (es) 2013-11-01
HUE049273T2 (hu) 2020-09-28
AP3787A (en) 2016-08-31
CN103338749A (zh) 2013-10-02
UA111835C2 (uk) 2016-06-24
LT2648696T (lt) 2020-05-11
BR112013014388A2 (pt) 2016-09-27
AP2013006971A0 (en) 2013-07-31
KR20130124335A (ko) 2013-11-13
ECSP13012665A (es) 2013-08-30
SI2648696T1 (sl) 2020-07-31
IL226775A (en) 2017-09-28
CY1123056T1 (el) 2021-10-29
SG191068A1 (en) 2013-07-31
EA022730B1 (ru) 2016-02-29
AU2011340500A1 (en) 2013-06-27
JP5847192B2 (ja) 2016-01-20
EP2648696A1 (en) 2013-10-16
JP2014503512A (ja) 2014-02-13
MX354858B (es) 2018-03-23
CO6731092A2 (es) 2013-08-15
PL2648696T3 (pl) 2020-07-27
EP2462922A1 (en) 2012-06-13
KR101837685B1 (ko) 2018-03-12
CN103338749B (zh) 2017-04-26
US9439853B2 (en) 2016-09-13
DK2648696T3 (da) 2020-05-04
NZ611597A (en) 2015-01-30
RS60197B1 (sr) 2020-06-30
WO2012076691A1 (en) 2012-06-14
ES2791710T3 (es) 2020-11-05
EP2648696B1 (en) 2020-02-19
PT2648696T (pt) 2020-05-13
HRP20200555T1 (hr) 2020-07-24

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