EA201290774A1 - Пиразолопиридиновые, пиразолопиразиновые, пиразолопиримидиновые, пиразолотиофеновые и пиразолотиазоловые соединения как аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций - Google Patents

Пиразолопиридиновые, пиразолопиразиновые, пиразолопиримидиновые, пиразолотиофеновые и пиразолотиазоловые соединения как аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций

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Publication number
EA201290774A1
EA201290774A1 EA201290774A EA201290774A EA201290774A1 EA 201290774 A1 EA201290774 A1 EA 201290774A1 EA 201290774 A EA201290774 A EA 201290774A EA 201290774 A EA201290774 A EA 201290774A EA 201290774 A1 EA201290774 A1 EA 201290774A1
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EA
Eurasian Patent Office
Prior art keywords
pyrazolothiophene
compounds
pyrazolotiazolic
pyrazolopirymidinovye
pyrazolopiridinovye
Prior art date
Application number
EA201290774A
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English (en)
Inventor
П. Джеффри Конн
Крейг В. Линдслей
Кори Р. Хопкинз
Коллин М. Нисуэндер
Рокко Д. Гоглиотти
Джеймз М. Салович
Даррен В. Энгерс
Иу-Инь Чхын
Original Assignee
Вандербилт Юниверсити
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Publication of EA201290774A1 publication Critical patent/EA201290774A1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Пиразолопиридиновые, пиразолопиразиновые, пиразолопиримидиновые, пиразолотиофеновые и пиразолотиазоловые соединения, которые пригодны как аллостерические усилители активности/позитивные аллостерические модуляторы метаботропного глутаматного рецептора подтипа 4 (mGluR4); способов синтеза для получения этих соединений; фармацевтических композиций, содержащих эти соединения; и способов применения этих соединений, например, для лечения неврологических и психических расстройств, связанных с дисфункцией глутаматергической нейротрансмиссии.
EA201290774A 2010-02-11 2011-02-11 Пиразолопиридиновые, пиразолопиразиновые, пиразолопиримидиновые, пиразолотиофеновые и пиразолотиазоловые соединения как аллостерические потенциаторы mglur4, композиции и способы лечения неврологических дисфункций EA201290774A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30348110P 2010-02-11 2010-02-11
US201161430521P 2011-01-06 2011-01-06
PCT/US2011/024618 WO2011100607A1 (en) 2010-02-11 2011-02-11 Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mglur4 allosteric potentiators, compounds, and methods of treating neurological dysfunction

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EA201290774A1 true EA201290774A1 (ru) 2013-03-29

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US (2) US9163015B2 (ru)
EP (1) EP2533639A4 (ru)
JP (1) JP5883399B2 (ru)
KR (1) KR20130029368A (ru)
CN (1) CN102892288B (ru)
AU (1) AU2011215638B2 (ru)
BR (1) BR112012020273A8 (ru)
CA (1) CA2789427A1 (ru)
CL (1) CL2012002225A1 (ru)
EA (1) EA201290774A1 (ru)
IL (1) IL221390A0 (ru)
MX (1) MX2012009378A (ru)
SG (1) SG183263A1 (ru)
TN (1) TN2012000400A1 (ru)
WO (1) WO2011100607A1 (ru)
ZA (1) ZA201206416B (ru)

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US8759377B2 (en) 2009-11-23 2014-06-24 Vanderbilt University Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
AU2011215638B2 (en) * 2010-02-11 2016-04-28 Vanderbilt University Pyrazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolothiophene and pyrazolothiazole compounds as mGluR4 allosteric potentiators, compounds, and methods of treating neurological dysfunction
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