EA201290592A1 - Способ получения ранелата стронция - Google Patents
Способ получения ранелата стронцияInfo
- Publication number
- EA201290592A1 EA201290592A1 EA201290592A EA201290592A EA201290592A1 EA 201290592 A1 EA201290592 A1 EA 201290592A1 EA 201290592 A EA201290592 A EA 201290592A EA 201290592 A EA201290592 A EA 201290592A EA 201290592 A1 EA201290592 A1 EA 201290592A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oxido
- oxoethyl
- strontium ranelate
- obtaining strontium
- thiophene
- Prior art date
Links
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229940079488 strontium ranelate Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- BGSCYLLQJSFPAG-UHFFFAOYSA-N tetraazanium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate Chemical compound N.N.N.N.OC(=O)CN(CC(O)=O)C=1SC(C(O)=O)=C(CC(O)=O)C=1C#N BGSCYLLQJSFPAG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к способу синтеза 5-[бис(2-оксидо-2-оксоэтил)амино]-4-циано-3-(2-оксидо-2-оксоэтил)тиофен-2-карбоксилата дистронция (ранелата стронция) формулы (I), начиная с нового соединения формулы (II) 5-[бис(2-оксидо-2-оксоэтил)амино]-4-циано-3-(2-оксидо-2-оксоэтил)тиофен-2-карбоксилата тетрааммония, которое также является предметом изобретения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1000018A HU228820B1 (en) | 2010-01-14 | 2010-01-14 | Process for the preparation of distrontium ranelate |
PCT/HU2011/000006 WO2011086399A1 (en) | 2010-01-14 | 2011-01-14 | Process for the preparation of strontium ranelate |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201290592A1 true EA201290592A1 (ru) | 2013-05-30 |
Family
ID=89989497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201290592A EA201290592A1 (ru) | 2010-01-14 | 2011-01-14 | Способ получения ранелата стронция |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2523947A1 (ru) |
EA (1) | EA201290592A1 (ru) |
HU (1) | HU228820B1 (ru) |
WO (1) | WO2011086399A1 (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1398542B1 (it) * | 2010-03-05 | 2013-03-01 | Chemelectiva S R L | Processo per la preparazione di un polimorfo |
US8569514B1 (en) | 2012-05-17 | 2013-10-29 | Divi's Laboratories, Ltd. | Process for the preparation of strontium ranelate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
FR2844795B1 (fr) | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
WO2007020527A2 (en) | 2005-08-19 | 2007-02-22 | Glenmark Pharmaceuticals Limited | Process for the preparation of strontium ranelate |
FR2921367B1 (fr) | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
-
2010
- 2010-01-14 HU HU1000018A patent/HU228820B1/hu unknown
-
2011
- 2011-01-14 EA EA201290592A patent/EA201290592A1/ru unknown
- 2011-01-14 EP EP11703731A patent/EP2523947A1/en not_active Withdrawn
- 2011-01-14 WO PCT/HU2011/000006 patent/WO2011086399A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2011086399A1 (en) | 2011-07-21 |
HU1000018D0 (en) | 2010-03-29 |
EP2523947A1 (en) | 2012-11-21 |
HU228820B1 (en) | 2013-05-28 |
HUP1000018A2 (en) | 2011-10-28 |
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