EA201200241A1 - Новая кристаллическая форма органического соединения и способ её получения - Google Patents
Новая кристаллическая форма органического соединения и способ её полученияInfo
- Publication number
- EA201200241A1 EA201200241A1 EA201200241A EA201200241A EA201200241A1 EA 201200241 A1 EA201200241 A1 EA 201200241A1 EA 201200241 A EA201200241 A EA 201200241A EA 201200241 A EA201200241 A EA 201200241A EA 201200241 A1 EA201200241 A1 EA 201200241A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- obtaining
- organic compounds
- crystal form
- new crystal
- norpregna
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000002894 organic compounds Chemical class 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- JVBGZFRPTRKSBB-MJBQOYBXSA-N Telapristone acetate Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(C(=O)COC)OC(C)=O)=CC=C(N(C)C)C=C1 JVBGZFRPTRKSBB-MJBQOYBXSA-N 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относится к новой кристаллической форме II 17α-ацетокси-21-метокси-11β-[4-N,N-диметиламинофенил]-19-норпрегна-4,9-диен-3,20-диона (также известного как CDB-4124), способам её получения и содержащей её фармацевтической композиции. Форма II может быть получена кристаллизацией из различных сред, например из сложных эфиров C-C-спиртов и карбоновых кислот, кетонов, циклогексана, ацетонитрила, диметилформамида, диметилсульфоксида, воды и их смесей.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0900487A HUP0900487A2 (hu) | 2009-08-05 | 2009-08-05 | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására |
PCT/HU2010/000088 WO2011015892A2 (en) | 2009-08-05 | 2010-08-05 | Novel crystal form of an organic compound and process for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201200241A1 true EA201200241A1 (ru) | 2012-07-30 |
EA019114B1 EA019114B1 (ru) | 2014-01-30 |
Family
ID=89989159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201200241A EA019114B1 (ru) | 2009-08-05 | 2010-08-05 | НОВАЯ КРИСТАЛЛИЧЕСКАЯ ФОРМА 17α-АЦЕТОКСИ-21-МЕТОКСИ-11β-[4-N,N-ДИМЕТИЛАМИНОФЕНИЛ]-19-НОРПРЕГНА-4,9-ДИЕН-3,20-ДИОНА И СПОСОБ ЕЁ ПОЛУЧЕНИЯ |
Country Status (7)
Country | Link |
---|---|
US (2) | US9221870B2 (ru) |
EP (1) | EP2462154B1 (ru) |
EA (1) | EA019114B1 (ru) |
ES (1) | ES2546098T3 (ru) |
HU (2) | HUP0900487A2 (ru) |
PL (1) | PL2462154T3 (ru) |
WO (1) | WO2011015892A2 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0900171A2 (hu) * | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
DE4042007A1 (de) * | 1990-12-22 | 1992-06-25 | Schering Ag | 6,7-modifizierte-11(beta)-aryl-4-estrene |
ES2152671T3 (es) | 1996-05-01 | 2001-02-01 | Us Gov Health & Human Serv | Derivados de progesterona sustituidos en posicion 21 como nuevos agentes antiprogestacionales. |
US6900193B1 (en) * | 1996-05-01 | 2005-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
US6768014B2 (en) * | 1999-12-29 | 2004-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | PROCESS FOR PREPARING 17α-ACETOXY-11β-[4-N,N(DIMETHYLAMINO)PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIENE-3,20-DIONE, INTERMEDIATES USEFUL IN THE PROCESS , AND PROCESSES FOR PREPARING SUCH INTERMEDIATES |
AU4584901A (en) | 2000-03-17 | 2001-10-15 | Us Gov Health & Human Serv | Structural modification of 19-norprogesterone i: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents |
US8044223B2 (en) | 2003-04-04 | 2011-10-25 | Bridge Organics Co. | Crystalline 19-norsteroids |
WO2007103510A2 (en) * | 2006-03-08 | 2007-09-13 | Danco Laboratories Llc | Methods, dosing regimens & medications using anti-progestational agents for the treatment of disorders |
CA2674440A1 (en) * | 2007-01-17 | 2008-07-24 | Repros Therapeutics Inc. | Methods for improved stability of steroid derivatives |
HU228636B1 (en) * | 2007-06-27 | 2013-04-29 | Richter Gedeon Nyrt | Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process |
TW201002736A (en) * | 2008-04-28 | 2010-01-16 | Repros Therapeutics Inc | Compositions and methods for treating progesterone-dependent conditions |
TWI477276B (zh) * | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
HUP0900171A2 (hu) * | 2009-03-20 | 2010-12-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos módosulata és eljárás elõállítására |
-
2009
- 2009-08-05 HU HU0900487A patent/HUP0900487A2/hu unknown
-
2010
- 2010-08-05 EP EP10747484.3A patent/EP2462154B1/en active Active
- 2010-08-05 US US13/387,783 patent/US9221870B2/en not_active Expired - Fee Related
- 2010-08-05 ES ES10747484.3T patent/ES2546098T3/es active Active
- 2010-08-05 WO PCT/HU2010/000088 patent/WO2011015892A2/en active Application Filing
- 2010-08-05 PL PL10747484T patent/PL2462154T3/pl unknown
- 2010-08-05 HU HUE10747484A patent/HUE025397T2/en unknown
- 2010-08-05 EA EA201200241A patent/EA019114B1/ru not_active IP Right Cessation
-
2015
- 2015-12-28 US US14/980,302 patent/US20160220585A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HUP0900487A2 (hu) | 2011-03-28 |
EP2462154B1 (en) | 2015-06-24 |
ES2546098T3 (es) | 2015-09-18 |
EA019114B1 (ru) | 2014-01-30 |
EP2462154A2 (en) | 2012-06-13 |
WO2011015892A2 (en) | 2011-02-10 |
HUE025397T2 (en) | 2016-02-29 |
HU0900487D0 (en) | 2009-09-28 |
PL2462154T3 (pl) | 2015-12-31 |
US9221870B2 (en) | 2015-12-29 |
WO2011015892A3 (en) | 2011-03-31 |
US20120142655A1 (en) | 2012-06-07 |
US20160220585A1 (en) | 2016-08-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |