EA201171074A1 - Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y - Google Patents
Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида yInfo
- Publication number
- EA201171074A1 EA201171074A1 EA201171074A EA201171074A EA201171074A1 EA 201171074 A1 EA201171074 A1 EA 201171074A1 EA 201171074 A EA201171074 A EA 201171074A EA 201171074 A EA201171074 A EA 201171074A EA 201171074 A1 EA201171074 A1 EA 201171074A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- neuropeptide
- receptor
- binding
- connection
- cytotoxic conjugates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Изобретение относится к группам новых конъюгатов нейропептида Y и цитотоксических соединений, к содержащим их композициям и способам, относящимся к их терапевтическому применению для лечения заболевания или состояния, ассоциированных с нарушенной или нежелательной пролиферацией клеток, которые экспрессируют рецепторы NPY-Y1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20815409P | 2009-02-20 | 2009-02-20 | |
PCT/US2010/000473 WO2010096175A1 (en) | 2009-02-20 | 2010-02-19 | Cytotoxic conjugates having neuropeptide y receptor binding compound |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201171074A1 true EA201171074A1 (ru) | 2012-04-30 |
EA020613B1 EA020613B1 (ru) | 2014-12-30 |
Family
ID=42634162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201171074A EA020613B1 (ru) | 2009-02-20 | 2010-02-19 | Цитотоксические конъюгаты с соединением, связывающим рецептор нейропептида y |
Country Status (12)
Country | Link |
---|---|
US (1) | US8877715B2 (ru) |
EP (1) | EP2398492A4 (ru) |
JP (1) | JP5584236B2 (ru) |
KR (1) | KR101413051B1 (ru) |
CN (1) | CN102325545A (ru) |
AU (1) | AU2010216372B2 (ru) |
BR (1) | BRPI1008039A2 (ru) |
CA (1) | CA2752608A1 (ru) |
EA (1) | EA020613B1 (ru) |
MX (1) | MX2011008774A (ru) |
UA (1) | UA102432C2 (ru) |
WO (1) | WO2010096175A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2600440C3 (ru) | 2010-12-16 | 2021-12-10 | Ново Нордиск А/С | Твердые композиции, содержащие агонист glp-1 и соль n-(8-(2-гидроксибензоил)амино)каприловой кислоты |
US10933120B2 (en) | 2012-03-22 | 2021-03-02 | Novo Nordisk A/S | Compositions of GLP-1 peptides and preparation thereof |
EP2708243A1 (en) * | 2012-09-17 | 2014-03-19 | OntoChem GmbH | Receptor ligand linked cytotoxic molecules |
US9777039B2 (en) | 2012-11-01 | 2017-10-03 | Ipsen Pharma S.A.S. | Somatostatin analogs and dimers thereof |
TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素-多巴胺嵌合體類似物 |
TWI661835B (zh) | 2013-11-15 | 2019-06-11 | 丹麥商諾佛 儂迪克股份有限公司 | 選擇性pyy化合物及其用途 |
JP6629198B2 (ja) | 2013-11-15 | 2020-01-15 | ノヴォ ノルディスク アー/エス | 35位にβ−ホモアルギニン置換を有するHPYY(1−36) |
RU2726777C2 (ru) | 2015-06-12 | 2020-07-15 | Ново Нордиск А/С | Селективные соединения пептида yy и их применения |
WO2017156183A1 (en) * | 2016-03-08 | 2017-09-14 | Los Gatos Pharmaceuticals, Inc. | Camptothecin derivatives and uses thereof |
JP2019510085A (ja) | 2016-03-08 | 2019-04-11 | ロス ガトス ファーマスーティカルズ, インク.Los Gatos Pharmaceuticals, Inc. | 癌治療のためのナノ粒子ならびに方法および化合物 |
CN106279287B (zh) * | 2016-08-12 | 2018-11-30 | 华中科技大学 | 一种喜树碱磷酸酯类化合物、其制备方法及应用 |
EP3746111B1 (en) | 2018-02-02 | 2023-07-19 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
WO2019197469A1 (en) * | 2018-04-10 | 2019-10-17 | Sanofi-Aventis Deutschland Gmbh | Lixisenatide synthesis with capping |
WO2021013999A1 (en) * | 2019-07-24 | 2021-01-28 | Ontochem Gmbh | Receptor-targeting peptide-drug conjugates |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7174494A (en) * | 1993-06-18 | 1995-01-17 | University Of Cincinnati, The | Neuropeptide y antagonists and agonists |
US20030022277A1 (en) * | 1995-05-05 | 2003-01-30 | Daniel R. Soppet | Human neuropeptide receptor |
US5843903A (en) * | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
US20030190740A1 (en) * | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
AU4267700A (en) * | 2000-01-13 | 2001-07-19 | Academia Sinica | Application of somatostatin analogs to specific delivery of anti-tumor drugs into tumor cells |
ATE368476T1 (de) * | 2000-11-24 | 2007-08-15 | Jean-Claude Reubi | Neuropeptid-y1-rezeptor-bindende verbindungen zur behandlung und diagnose von krebserkrankungen |
WO2007039318A2 (en) * | 2005-10-06 | 2007-04-12 | Bayer Schering Pharma Aktiengesellschaft | Neuropeptide y analogs |
EP1900742A1 (en) * | 2006-09-07 | 2008-03-19 | AEterna Zentaris GmbH | Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof |
MX2009004178A (es) * | 2006-10-20 | 2009-09-07 | Ipsen Pharma Sas | Conjugados peptidicos citotoxicos. |
WO2008098788A2 (en) * | 2007-02-16 | 2008-08-21 | Ktb Tumorforschungsgesellschaft Mbh | Receptor and antigen targeted prodrug |
UA101435C2 (ru) * | 2009-02-20 | 2013-03-25 | Ипсен Фарма С.А.С. | Аналоги нейропептида y, которые содержат по меньшей мере одну замену на синтетическую аминокислоту |
-
2010
- 2010-02-19 BR BRPI1008039A patent/BRPI1008039A2/pt not_active IP Right Cessation
- 2010-02-19 JP JP2011551063A patent/JP5584236B2/ja not_active Expired - Fee Related
- 2010-02-19 KR KR1020117020920A patent/KR101413051B1/ko not_active IP Right Cessation
- 2010-02-19 AU AU2010216372A patent/AU2010216372B2/en not_active Ceased
- 2010-02-19 CN CN2010800086125A patent/CN102325545A/zh active Pending
- 2010-02-19 MX MX2011008774A patent/MX2011008774A/es not_active Application Discontinuation
- 2010-02-19 CA CA2752608A patent/CA2752608A1/en not_active Abandoned
- 2010-02-19 EA EA201171074A patent/EA020613B1/ru not_active IP Right Cessation
- 2010-02-19 UA UAA201111162A patent/UA102432C2/ru unknown
- 2010-02-19 EP EP10744060.4A patent/EP2398492A4/en not_active Withdrawn
- 2010-02-19 WO PCT/US2010/000473 patent/WO2010096175A1/en active Application Filing
-
2011
- 2011-08-18 US US13/212,242 patent/US8877715B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EA020613B1 (ru) | 2014-12-30 |
JP5584236B2 (ja) | 2014-09-03 |
MX2011008774A (es) | 2011-10-24 |
US8877715B2 (en) | 2014-11-04 |
US20120010154A1 (en) | 2012-01-12 |
KR20110125235A (ko) | 2011-11-18 |
EP2398492A1 (en) | 2011-12-28 |
JP2012518636A (ja) | 2012-08-16 |
AU2010216372B2 (en) | 2013-06-20 |
WO2010096175A1 (en) | 2010-08-26 |
UA102432C2 (ru) | 2013-07-10 |
EP2398492A4 (en) | 2013-07-17 |
AU2010216372A1 (en) | 2011-09-15 |
CN102325545A (zh) | 2012-01-18 |
KR101413051B1 (ko) | 2014-07-31 |
BRPI1008039A2 (pt) | 2016-10-04 |
CA2752608A1 (en) | 2010-08-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG MD TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ RU |