EA201170421A1 - N-сульфонамидопиразолильные полициклические соединения - Google Patents

N-сульфонамидопиразолильные полициклические соединения

Info

Publication number
EA201170421A1
EA201170421A1 EA201170421A EA201170421A EA201170421A1 EA 201170421 A1 EA201170421 A1 EA 201170421A1 EA 201170421 A EA201170421 A EA 201170421A EA 201170421 A EA201170421 A EA 201170421A EA 201170421 A1 EA201170421 A1 EA 201170421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
sulphonamidopyrazolyl
compounds
polycyclic compounds
formulas
ring
Prior art date
Application number
EA201170421A
Other languages
English (en)
Inventor
Андрей В. Конради
Сяоцун Майкл Е
Симеон Бауэрс
Альберт В. Гарофэло
Даниелль Л. Обель
Даррен Дрессен
Реймонд Нг
Гэри Пробст
Кристофер М. Семко
Миньхуа Сунь
Ань П. Труонг
Майкл С. Дэппен
Original Assignee
Элан Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элан Фармасьютикалз, Инк. filed Critical Элан Фармасьютикалз, Инк.
Publication of EA201170421A1 publication Critical patent/EA201170421A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Настоящее изобретение относится к соединениям, имеющим структуру согласно формулам 1-4в которых А-кольцо, В-кольцо, С-кольцо, m, n, R, Rи Rимеют значения, определенные в описании. Изобретение также относится к фармацевтическим композициям, включающим соединения формул 1-4, а также к способам лечения когнитивных нарушений, таких как болезнь Альцгеймера. Изобретение также относится к промежуточным соединениям, пригодным для получения соединений формул 1-4.
EA201170421A 2008-09-05 2009-09-04 N-сульфонамидопиразолильные полициклические соединения EA201170421A1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9479908P 2008-09-05 2008-09-05
US9924108P 2008-09-23 2008-09-23
US17327809P 2009-04-28 2009-04-28
US22653209P 2009-07-17 2009-07-17
PCT/US2009/055987 WO2010028213A2 (en) 2008-09-05 2009-09-04 N-sulfonamido polycyclic pyrazolyl compounds

Publications (1)

Publication Number Publication Date
EA201170421A1 true EA201170421A1 (ru) 2012-01-30

Family

ID=41258775

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170421A EA201170421A1 (ru) 2008-09-05 2009-09-04 N-сульфонамидопиразолильные полициклические соединения

Country Status (20)

Country Link
US (1) US8283358B2 (ru)
EP (1) EP2346863A2 (ru)
JP (1) JP2012502051A (ru)
KR (1) KR20110055715A (ru)
CN (1) CN102203089A (ru)
AR (1) AR073497A1 (ru)
AU (1) AU2009289579A1 (ru)
BR (1) BRPI0918213A2 (ru)
CA (1) CA2736767A1 (ru)
CL (1) CL2011000405A1 (ru)
CO (1) CO6362008A2 (ru)
EA (1) EA201170421A1 (ru)
EC (1) ECSP11010947A (ru)
IL (1) IL211263A0 (ru)
MA (1) MA32688B1 (ru)
MX (1) MX2011002047A (ru)
PE (1) PE20110418A1 (ru)
TW (1) TW201014856A (ru)
WO (1) WO2010028213A2 (ru)
ZA (1) ZA201101994B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2620027T3 (es) 2008-09-03 2017-06-27 Biomarin Pharmaceutical Inc. Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC
PE20110418A1 (es) 2008-09-05 2011-06-22 Elan Pharm Inc Compuestos n-sulfonamido pirazolil policiclicos
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP2680694B1 (en) 2011-02-28 2019-01-02 BioMarin Pharmaceutical Inc. Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
RU2665554C2 (ru) 2013-03-15 2018-08-31 Байомарин Фармасьютикал Инк. Ингибиторы hdac
US20230116114A1 (en) * 2020-01-03 2023-04-13 Blue Oak Pharmaceuticals, Inc. Compounds and compositions for treating cns disorders
CN111909217B (zh) * 2020-08-20 2023-05-02 昆明贵金属研究所 一种双（二叔丁基-4-二甲氨基苯基膦）四溴双钯(ⅱ)化合物及其制备方法和用途
CN115448892B (zh) * 2022-09-19 2023-07-07 郑州铁路职业技术学院 一种苯并噻二唑杂环化合物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8727989D0 (en) * 1987-11-30 1988-01-06 Merck Sharp & Dohme Therapeutic agents
EP0330788A1 (en) 1988-03-01 1989-09-06 Merrell Dow Pharmaceuticals Inc. Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
US20060035884A1 (en) * 2004-05-20 2006-02-16 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
JP2009506988A (ja) * 2005-08-19 2009-02-19 エラン ファーマシューティカルズ，インコーポレイテッド ガンマセクレターゼの架橋ｎ−環状スルホンアミド阻害剤
TW200813054A (en) * 2006-06-02 2008-03-16 Elan Pharm Inc Fused, tricyclic sulfonamide inhibitors of gamma secretase
CN101128035B (zh) 2006-08-18 2011-08-24 中兴通讯股份有限公司 时分码分多址***中信道间的定时方法
EP2152713B1 (en) * 2007-05-25 2011-09-07 Elan Pharmaceuticals Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
PE20110418A1 (es) 2008-09-05 2011-06-22 Elan Pharm Inc Compuestos n-sulfonamido pirazolil policiclicos

Also Published As

Publication number Publication date
KR20110055715A (ko) 2011-05-25
WO2010028213A3 (en) 2010-06-03
CA2736767A1 (en) 2010-03-11
ZA201101994B (en) 2011-11-30
CO6362008A2 (es) 2012-01-20
AR073497A1 (es) 2010-11-10
JP2012502051A (ja) 2012-01-26
CL2011000405A1 (es) 2011-07-01
TW201014856A (en) 2010-04-16
EP2346863A2 (en) 2011-07-27
PE20110418A1 (es) 2011-06-22
US8283358B2 (en) 2012-10-09
CN102203089A (zh) 2011-09-28
MX2011002047A (es) 2011-06-17
MA32688B1 (fr) 2011-10-02
AU2009289579A1 (en) 2010-03-11
IL211263A0 (en) 2011-04-28
US20100081680A1 (en) 2010-04-01
WO2010028213A2 (en) 2010-03-11
ECSP11010947A (es) 2011-07-29
BRPI0918213A2 (pt) 2015-12-08

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