EA201071000A1 - Способ разделения производных изохинолина - Google Patents

Способ разделения производных изохинолина

Info

Publication number
EA201071000A1
EA201071000A1 EA201071000A EA201071000A EA201071000A1 EA 201071000 A1 EA201071000 A1 EA 201071000A1 EA 201071000 A EA201071000 A EA 201071000A EA 201071000 A EA201071000 A EA 201071000A EA 201071000 A1 EA201071000 A1 EA 201071000A1
Authority
EA
Eurasian Patent Office
Prior art keywords
separation
isoquinoline derivatives
isoquinoline
derivatives
tetrahydropapaverine
Prior art date
Application number
EA201071000A
Other languages
English (en)
Other versions
EA017743B1 (ru
Inventor
Франка Сеньялини
Анджела Туоцци
Анджело Джентиле
Original Assignee
Рекордати Индустрия Кимика Э Фармасеутика С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рекордати Индустрия Кимика Э Фармасеутика С.П.А. filed Critical Рекордати Индустрия Кимика Э Фармасеутика С.П.А.
Publication of EA201071000A1 publication Critical patent/EA201071000A1/ru
Publication of EA017743B1 publication Critical patent/EA017743B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описан способ разделения рацемического тетрагидропапаверина с помощью оптически активных арилпропионовых кислот.
EA201071000A 2008-02-28 2009-02-25 Способ разделения рацемического тетрагидропапаверина EA017743B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000319A ITMI20080319A1 (it) 2008-02-28 2008-02-28 Processo per la risoluzione di derivati isochinolinici
PCT/EP2009/052234 WO2009106547A1 (en) 2008-02-28 2009-02-25 Process for the resolution of isoquinoline derivatives

Publications (2)

Publication Number Publication Date
EA201071000A1 true EA201071000A1 (ru) 2011-02-28
EA017743B1 EA017743B1 (ru) 2013-02-28

Family

ID=40291711

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071000A EA017743B1 (ru) 2008-02-28 2009-02-25 Способ разделения рацемического тетрагидропапаверина

Country Status (14)

Country Link
US (1) US8703955B2 (ru)
EP (1) EP2268617B1 (ru)
CN (1) CN101896462B (ru)
AT (1) ATE534631T1 (ru)
CA (1) CA2708666C (ru)
EA (1) EA017743B1 (ru)
ES (1) ES2375920T3 (ru)
HK (1) HK1150239A1 (ru)
HR (1) HRP20110941T1 (ru)
IL (1) IL206444A (ru)
IT (1) ITMI20080319A1 (ru)
PL (1) PL2268617T3 (ru)
SI (1) SI2268617T1 (ru)
WO (1) WO2009106547A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0808272A2 (pt) * 2007-03-08 2014-07-08 Chemagis Ltd "método para cromatograficamente separar o isômero 1r-cis, 1´r-cis de uma mistura de isômeros de (1r-1'r) - atracúrio, besilato de cisatracúrio e isômero 1r-cis, 1'r-cis do besilato de cisatracúrio"
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
CA2685488A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
BRPI0816519A2 (pt) * 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
WO2009133556A2 (en) * 2008-05-01 2009-11-05 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8148527B1 (en) * 2011-01-18 2012-04-03 Divi's Laboratories, Ltd. Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline
CN103319406A (zh) * 2012-03-20 2013-09-25 迪维斯实验室有限公司 1-(4-甲氧苄基)-八氢-异喹啉的拆分
CN104610145B (zh) * 2015-01-27 2017-07-18 江苏嘉逸医药有限公司 苯磺顺阿曲库铵中间体r‑四氢罂粟碱‑n‑乙酰‑l‑亮氨酸盐的分离方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
DE19711739C1 (de) 1997-03-20 1998-08-20 Knorr Bremse Systeme Governor für Druckluftbeschaffungsanlagen von Fahrzeugen
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
EP1831132A2 (en) * 2004-08-02 2007-09-12 Matrix Laboratories Ltd Resolution of racemic organic acids with (1s, 4s)-4[3,4-dichlorophenyl]-1,2,3,4- tetrahydro-n-methyl-1-naphthaloneamine
KR20070080108A (ko) 2006-02-06 2007-08-09 주식회사종근당 질소의 알파 위치에 비대칭탄소가 있는 라세믹 유도체의광학 이성질체 분리 방법

Also Published As

Publication number Publication date
ES2375920T3 (es) 2012-03-07
PL2268617T3 (pl) 2012-05-31
EP2268617A1 (en) 2011-01-05
EA017743B1 (ru) 2013-02-28
HK1150239A1 (en) 2011-11-11
CA2708666C (en) 2016-06-14
ITMI20080319A1 (it) 2009-08-29
HRP20110941T1 (hr) 2012-03-31
ATE534631T1 (de) 2011-12-15
CN101896462B (zh) 2012-09-26
CA2708666A1 (en) 2009-09-03
IL206444A0 (en) 2010-12-30
WO2009106547A1 (en) 2009-09-03
US20100298570A1 (en) 2010-11-25
SI2268617T1 (sl) 2012-05-31
IL206444A (en) 2013-10-31
US8703955B2 (en) 2014-04-22
EP2268617B1 (en) 2011-11-23
CN101896462A (zh) 2010-11-24

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