EA201001569A1 - Инкапсуляция биологически активных агентов - Google Patents
Инкапсуляция биологически активных агентовInfo
- Publication number
- EA201001569A1 EA201001569A1 EA201001569A EA201001569A EA201001569A1 EA 201001569 A1 EA201001569 A1 EA 201001569A1 EA 201001569 A EA201001569 A EA 201001569A EA 201001569 A EA201001569 A EA 201001569A EA 201001569 A1 EA201001569 A1 EA 201001569A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- biologically active
- active agents
- incapsulation
- agents
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Согласно настоящему изобретению предложены способы инкапсуляции биологически активных агентов, таких как белки, в носители в форме частиц, такие как наночастицы, с использованием агентов для образования пар гидрофобных ионов (HIP-агентов). Также предложены композиции, содержащие носители в форме частиц, получаемые такими способами, и применения таких композиций в лечении.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5077508P | 2008-05-06 | 2008-05-06 | |
US7417108P | 2008-06-20 | 2008-06-20 | |
PCT/EP2009/055438 WO2009135855A2 (en) | 2008-05-06 | 2009-05-05 | Encapsulation of biologically active agents |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201001569A1 true EA201001569A1 (ru) | 2011-10-31 |
Family
ID=43125562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001569A EA201001569A1 (ru) | 2008-05-06 | 2009-05-05 | Инкапсуляция биологически активных агентов |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110059142A1 (ru) |
EP (1) | EP2273986A2 (ru) |
JP (1) | JP2011519894A (ru) |
CN (1) | CN102215830A (ru) |
AU (1) | AU2009245786A1 (ru) |
BR (1) | BRPI0912230A2 (ru) |
CA (1) | CA2721350A1 (ru) |
EA (1) | EA201001569A1 (ru) |
IL (1) | IL208655A0 (ru) |
MX (1) | MX2010012136A (ru) |
WO (1) | WO2009135855A2 (ru) |
ZA (1) | ZA201007436B (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011520802A (ja) * | 2008-05-06 | 2011-07-21 | グラクソ グループ リミテッド | 生物活性薬の封入 |
AU2014318566A1 (en) * | 2013-09-12 | 2016-04-07 | Thomas Jefferson University | Novel delivery compositions and methods of using same |
CN106163503B (zh) * | 2014-03-14 | 2021-02-26 | 辉瑞大药厂 | 包含治疗剂的治疗性纳米颗粒及其制造及使用方法 |
EP3148516A1 (en) * | 2014-05-30 | 2017-04-05 | AbbVie Deutschland GmbH & Co. KG | Nanoencapsulation of antigen-binding molecules |
AU2015284236B2 (en) | 2014-06-30 | 2018-03-08 | Tva (Abc), Llc | Targeted conjugates and particles and formulations thereof |
CN104771362B (zh) * | 2014-09-03 | 2018-01-02 | 沈阳药科大学 | 一种克拉霉素离子对脂质微球注射液及其制备方法 |
JP7057278B2 (ja) | 2015-10-28 | 2022-04-19 | ターベダ セラピューティクス インコーポレイテッド | Sstr標的化コンジュゲート及び粒子並びにその製剤 |
WO2017085212A2 (en) * | 2015-11-20 | 2017-05-26 | AbbVie Deutschland GmbH & Co. KG | Surface-modified nanospheres encapsulating antigen-binding molecules |
US11833486B2 (en) * | 2015-11-29 | 2023-12-05 | Berney PENG | Functionalized nanoparticles having encapsulated guest cargo and methods for making the same |
US11484505B2 (en) | 2016-10-13 | 2022-11-01 | Thomas Jefferson University | Delivery compositions, and methods of making and using same |
CN109260174B (zh) * | 2018-09-04 | 2021-10-15 | 中山大学 | 一种治疗性蛋白纳米颗粒的高通量制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2649321A1 (fr) * | 1989-07-07 | 1991-01-11 | Inst Nat Sante Rech Med | Compositions a base de derives nucleotidiques, leurs procedes de preparation, et leurs utilisations notamment en tant que compositions pharmaceutiques |
FR2659554B1 (fr) * | 1990-03-16 | 1994-09-30 | Oreal | Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant. |
GB9300875D0 (en) * | 1993-01-18 | 1993-03-10 | Ucb Sa | Nanocapsule containing pharmaceutical compositions |
WO1995007072A2 (de) * | 1993-09-09 | 1995-03-16 | Schering Aktiengesellschaft | Wirkstoffe und gas enthaltende mikropartikel |
US20030152636A1 (en) * | 2000-02-23 | 2003-08-14 | Nanopharm Ag | Method of treating cancer |
EP1417236A4 (en) * | 2001-07-10 | 2010-03-17 | Corixa Corp | COMPOSITIONS AND METHODS FOR ADMINISTRATION OF ENCAPSULATED PROTEINS AND ADJUVANTS IN MICROSPHERES |
ES2741576T3 (es) * | 2003-07-23 | 2020-02-11 | Evonik Corp | Composiciones de liberación controlada |
-
2009
- 2009-05-05 CN CN2009801268147A patent/CN102215830A/zh active Pending
- 2009-05-05 BR BRPI0912230A patent/BRPI0912230A2/pt not_active IP Right Cessation
- 2009-05-05 CA CA2721350A patent/CA2721350A1/en not_active Abandoned
- 2009-05-05 JP JP2011507899A patent/JP2011519894A/ja active Pending
- 2009-05-05 AU AU2009245786A patent/AU2009245786A1/en not_active Abandoned
- 2009-05-05 MX MX2010012136A patent/MX2010012136A/es not_active Application Discontinuation
- 2009-05-05 WO PCT/EP2009/055438 patent/WO2009135855A2/en active Application Filing
- 2009-05-05 US US12/991,508 patent/US20110059142A1/en not_active Abandoned
- 2009-05-05 EA EA201001569A patent/EA201001569A1/ru unknown
- 2009-05-05 EP EP09742073A patent/EP2273986A2/en not_active Withdrawn
-
2010
- 2010-10-12 IL IL208655A patent/IL208655A0/en unknown
- 2010-10-18 ZA ZA2010/07436A patent/ZA201007436B/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2009135855A2 (en) | 2009-11-12 |
US20110059142A1 (en) | 2011-03-10 |
WO2009135855A3 (en) | 2011-01-27 |
EP2273986A2 (en) | 2011-01-19 |
CA2721350A1 (en) | 2009-11-12 |
MX2010012136A (es) | 2010-12-17 |
BRPI0912230A2 (pt) | 2017-08-22 |
CN102215830A (zh) | 2011-10-12 |
ZA201007436B (en) | 2012-03-28 |
AU2009245786A1 (en) | 2009-11-12 |
JP2011519894A (ja) | 2011-07-14 |
IL208655A0 (en) | 2010-12-30 |
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