EA200971092A1 - Vegf-d мутанты и их применение - Google Patents
Vegf-d мутанты и их применениеInfo
- Publication number
- EA200971092A1 EA200971092A1 EA200971092A EA200971092A EA200971092A1 EA 200971092 A1 EA200971092 A1 EA 200971092A1 EA 200971092 A EA200971092 A EA 200971092A EA 200971092 A EA200971092 A EA 200971092A EA 200971092 A1 EA200971092 A1 EA 200971092A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- vegf
- mutants
- application
- angiogenesis
- promotion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение представляет собой белки VEGF-D, содержащие одну или более аминокислотных мутаций в области, участвующей в контакте мономеров при образовании димера, и их применение в терапии, в частности для содействия ангиогенезу.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0710457.3A GB0710457D0 (en) | 2007-05-31 | 2007-05-31 | Vegf Mutants |
PCT/GB2008/001873 WO2008146023A1 (en) | 2007-05-31 | 2008-06-02 | Vegf-d mutants and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200971092A1 true EA200971092A1 (ru) | 2010-06-30 |
Family
ID=38289657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200971092A EA200971092A1 (ru) | 2007-05-31 | 2008-06-02 | Vegf-d мутанты и их применение |
Country Status (13)
Country | Link |
---|---|
US (1) | US8188039B2 (ru) |
EP (1) | EP2162463B1 (ru) |
JP (1) | JP2010527627A (ru) |
KR (1) | KR101522043B1 (ru) |
CN (1) | CN101730710A (ru) |
AT (1) | ATE550351T1 (ru) |
AU (1) | AU2008256550B2 (ru) |
BR (1) | BRPI0812026A2 (ru) |
CA (1) | CA2688543C (ru) |
EA (1) | EA200971092A1 (ru) |
GB (1) | GB0710457D0 (ru) |
MX (1) | MX2009012599A (ru) |
WO (1) | WO2008146023A1 (ru) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2751445C (en) * | 2009-02-06 | 2018-06-19 | Pepscan Systems B.V. | Truncated cystine-knot proteins |
CN102336811B (zh) * | 2010-07-26 | 2016-03-16 | 上海市第一人民医院 | 一类新的抑制新生血管的小肽及其应用 |
WO2012088563A1 (en) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof |
-
2007
- 2007-05-31 GB GBGB0710457.3A patent/GB0710457D0/en not_active Ceased
-
2008
- 2008-06-02 EA EA200971092A patent/EA200971092A1/ru unknown
- 2008-06-02 MX MX2009012599A patent/MX2009012599A/es unknown
- 2008-06-02 CA CA2688543A patent/CA2688543C/en not_active Expired - Fee Related
- 2008-06-02 KR KR1020097026902A patent/KR101522043B1/ko not_active IP Right Cessation
- 2008-06-02 CN CN200880018138A patent/CN101730710A/zh active Pending
- 2008-06-02 BR BRPI0812026A patent/BRPI0812026A2/pt not_active IP Right Cessation
- 2008-06-02 WO PCT/GB2008/001873 patent/WO2008146023A1/en active Application Filing
- 2008-06-02 AT AT08762227T patent/ATE550351T1/de active
- 2008-06-02 EP EP08762227A patent/EP2162463B1/en active Active
- 2008-06-02 JP JP2010509898A patent/JP2010527627A/ja active Pending
- 2008-06-02 US US12/599,294 patent/US8188039B2/en active Active
- 2008-06-02 AU AU2008256550A patent/AU2008256550B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US20110144013A1 (en) | 2011-06-16 |
KR20100040805A (ko) | 2010-04-21 |
US8188039B2 (en) | 2012-05-29 |
BRPI0812026A2 (pt) | 2015-09-29 |
AU2008256550B2 (en) | 2012-02-09 |
CN101730710A (zh) | 2010-06-09 |
GB0710457D0 (en) | 2007-07-11 |
WO2008146023A1 (en) | 2008-12-04 |
JP2010527627A (ja) | 2010-08-19 |
MX2009012599A (es) | 2009-12-11 |
EP2162463A1 (en) | 2010-03-17 |
CA2688543C (en) | 2017-08-22 |
KR101522043B1 (ko) | 2015-05-20 |
AU2008256550A1 (en) | 2008-12-04 |
CA2688543A1 (en) | 2008-12-04 |
EP2162463B1 (en) | 2012-03-21 |
ATE550351T1 (de) | 2012-04-15 |
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