EA200970615A1 - Соединения имидазолидинониламинопиримидина для лечения рака - Google Patents

Соединения имидазолидинониламинопиримидина для лечения рака

Info

Publication number
EA200970615A1
EA200970615A1 EA200970615A EA200970615A EA200970615A1 EA 200970615 A1 EA200970615 A1 EA 200970615A1 EA 200970615 A EA200970615 A EA 200970615A EA 200970615 A EA200970615 A EA 200970615A EA 200970615 A1 EA200970615 A1 EA 200970615A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydrogen
halo
imidazolidinoninilaminopyrimidine
compounds
methyl
Prior art date
Application number
EA200970615A
Other languages
English (en)
Other versions
EA016177B1 (ru
Inventor
Хун-Юй Ли
Харольд Бернс Брукс
Джойс З. Крич
Джеймс Роберт Генри
Мелисса Кейт Слейтер
Янь Ван
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200970615A1 publication Critical patent/EA200970615A1/ru
Publication of EA016177B1 publication Critical patent/EA016177B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение обеспечивает новые соединения имидазолидинониламинопиримидина, которые, как предполагают, можно применять в клинике для лечения рака посредством ингибирования Plk1, где R- водород, гидрокси, галоген, метил, C-Салкокси, амино или метиламино; R- водород, галоген или циано; R- водород или галоген; R- водород, галоген или метил; при условии, что по меньшей мере два из R, R, Rи Rявляются водородами; R- водород, галоген или метил, или фармацевтически приемлемые соли.
EA200970615A 2006-12-21 2007-12-11 Соединения имидазолидинониламинопиримидина для лечения рака EA016177B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87130206P 2006-12-21 2006-12-21
PCT/US2007/087044 WO2008076704A1 (en) 2006-12-21 2007-12-11 Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer

Publications (2)

Publication Number Publication Date
EA200970615A1 true EA200970615A1 (ru) 2009-10-30
EA016177B1 EA016177B1 (ru) 2012-02-28

Family

ID=39186811

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970615A EA016177B1 (ru) 2006-12-21 2007-12-11 Соединения имидазолидинониламинопиримидина для лечения рака

Country Status (14)

Country Link
US (1) US8101628B2 (ru)
EP (1) EP2125793B1 (ru)
JP (1) JP5166441B2 (ru)
KR (1) KR101088291B1 (ru)
CN (1) CN101563342B (ru)
AT (1) ATE479680T1 (ru)
AU (1) AU2007334039B2 (ru)
BR (1) BRPI0721045A2 (ru)
CA (1) CA2671738A1 (ru)
DE (1) DE602007008952D1 (ru)
EA (1) EA016177B1 (ru)
ES (1) ES2349169T3 (ru)
MX (1) MX2009006634A (ru)
WO (1) WO2008076704A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2125794E (pt) 2006-12-21 2011-01-10 Lilly Co Eli Compostos imidazolidinonilo aminopirimidina para o tratamento do cancro
CA2691997A1 (en) 2007-05-16 2008-11-27 Eli Lilly And Company Triazolyl aminopyrimidine compounds
MX2009012233A (es) 2007-05-16 2009-12-01 Lilly Co Eli Compuestos de triazolil aminopirimidina.
CN108853111B (zh) * 2018-08-07 2020-06-05 浙江大学 一种组合物在制备治疗吉非替尼肝脏毒性药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929726A (en) 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
WO2004063192A1 (en) * 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
JP2007533602A (ja) * 2003-07-31 2007-11-22 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 置換ベンゾチオフェン化合物及びそれらの使用
AU2005316312B2 (en) * 2004-12-17 2009-10-22 Amgen, Inc. Aminopyrimidine compounds and methods of use
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
MX2008012482A (es) * 2006-03-31 2008-10-10 Abbott Lab Compuestos de indazol.
PT2125794E (pt) 2006-12-21 2011-01-10 Lilly Co Eli Compostos imidazolidinonilo aminopirimidina para o tratamento do cancro
CA2691997A1 (en) 2007-05-16 2008-11-27 Eli Lilly And Company Triazolyl aminopyrimidine compounds
MX2009012233A (es) 2007-05-16 2009-12-01 Lilly Co Eli Compuestos de triazolil aminopirimidina.

Also Published As

Publication number Publication date
CA2671738A1 (en) 2008-06-26
US8101628B2 (en) 2012-01-24
KR101088291B1 (ko) 2011-11-30
EP2125793A1 (en) 2009-12-02
ES2349169T3 (es) 2010-12-28
US20100076001A1 (en) 2010-03-25
EA016177B1 (ru) 2012-02-28
WO2008076704A1 (en) 2008-06-26
EP2125793B1 (en) 2010-09-01
AU2007334039A1 (en) 2008-06-26
CN101563342B (zh) 2012-09-05
MX2009006634A (es) 2009-06-30
JP5166441B2 (ja) 2013-03-21
BRPI0721045A2 (pt) 2014-07-29
ATE479680T1 (de) 2010-09-15
AU2007334039B2 (en) 2012-02-16
DE602007008952D1 (de) 2010-10-14
KR20090086114A (ko) 2009-08-10
JP2010513552A (ja) 2010-04-30
CN101563342A (zh) 2009-10-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU