EA200970472A1 - Замещенные пиразолы, композиции, их содержащие, способ получения и применение - Google Patents

Замещенные пиразолы, композиции, их содержащие, способ получения и применение

Info

Publication number
EA200970472A1
EA200970472A1 EA200970472A EA200970472A EA200970472A1 EA 200970472 A1 EA200970472 A1 EA 200970472A1 EA 200970472 A EA200970472 A EA 200970472A EA 200970472 A EA200970472 A EA 200970472A EA 200970472 A1 EA200970472 A1 EA 200970472A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazoles
compositions
replaced
obtaining
application
Prior art date
Application number
EA200970472A
Other languages
English (en)
Other versions
EA019454B1 (ru
Inventor
Кирстен Бьергард
Марк Додсон
Жак Може
Анил Наир
Марсель Патек
Мишель Табар
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA200970472A1 publication Critical patent/EA200970472A1/ru
Publication of EA019454B1 publication Critical patent/EA019454B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

Abstract

Настоящее изобретение относится к новым химическим соединениям, в особенности к замещенным пиразолам, композициям их содержащим и их применению в качестве лекарственных средств.
EA200970472A 2006-11-10 2007-11-09 Замещенные пиразолы, композиции их содержащие, способ получения и применение EA019454B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0609812A FR2908409B1 (fr) 2006-11-10 2006-11-10 Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
PCT/FR2007/001851 WO2008065282A2 (fr) 2006-11-10 2007-11-09 Pyrazoles substituees, compositions les contenant, procede de fabrication et utilisation

Publications (2)

Publication Number Publication Date
EA200970472A1 true EA200970472A1 (ru) 2009-10-30
EA019454B1 EA019454B1 (ru) 2014-03-31

Family

ID=38169388

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970472A EA019454B1 (ru) 2006-11-10 2007-11-09 Замещенные пиразолы, композиции их содержащие, способ получения и применение

Country Status (40)

Country Link
US (3) US7989439B2 (ru)
EP (1) EP2091920B1 (ru)
JP (1) JP5538893B2 (ru)
KR (1) KR20090083456A (ru)
CN (1) CN101553473B (ru)
AR (1) AR063638A1 (ru)
AU (1) AU2007327423B2 (ru)
BR (1) BRPI0718999A2 (ru)
CA (1) CA2667846A1 (ru)
CL (1) CL2007003251A1 (ru)
CO (1) CO6190516A2 (ru)
CR (1) CR10749A (ru)
CY (1) CY1116000T1 (ru)
DK (1) DK2091920T3 (ru)
DO (1) DOP2009000088A (ru)
EA (1) EA019454B1 (ru)
EC (1) ECSP099312A (ru)
ES (1) ES2528385T3 (ru)
FR (1) FR2908409B1 (ru)
HK (1) HK1137988A1 (ru)
HN (1) HN2009000856A (ru)
HR (1) HRP20150070T1 (ru)
IL (1) IL198328A0 (ru)
MA (1) MA30972B1 (ru)
MX (1) MX2009004983A (ru)
MY (1) MY147502A (ru)
NI (1) NI200900078A (ru)
NO (1) NO20091990L (ru)
NZ (1) NZ576709A (ru)
PE (2) PE20121152A1 (ru)
PL (1) PL2091920T3 (ru)
PT (1) PT2091920E (ru)
SI (1) SI2091920T1 (ru)
SV (1) SV2009003253A (ru)
TN (1) TN2009000155A1 (ru)
TW (1) TW200829556A (ru)
UA (1) UA97965C2 (ru)
UY (1) UY30707A1 (ru)
WO (1) WO2008065282A2 (ru)
ZA (1) ZA200903560B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2605600C2 (ru) * 2011-01-26 2016-12-27 Санофи Амино-замещенные производные 3-гетероароиламинопропионовой кислоты и их применение в качестве фармацевтических средств

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858323B2 (en) * 2004-06-09 2010-12-28 The Regents Of The University Of Michigan Phage microarray profiling of the humoral response to disease
FR2947546B1 (fr) 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique
TWI532725B (zh) * 2010-01-26 2016-05-11 賽諾菲阿凡提斯公司 經氧取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途
CN102432639B (zh) * 2011-09-30 2013-11-06 山东大学 1-(2-羟基-3-(苯氨基)丙基)-3-二茂铁基-1h-吡唑-5-甲酸乙酯化合物及其应用
ES2625944T3 (es) 2012-11-02 2017-07-21 Pfizer Inc. Inhibidores de tirosina cinasa de Bruton
CA2976766A1 (en) * 2015-03-25 2016-09-29 Novartis Ag Formylated n-heterocyclic derivatives as fgfr4 inhibitors
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
CA2445357A1 (en) * 2001-04-27 2002-11-07 Vertex Pharmaceuticals Incorporated Pyrazole derived kinase inhibitors
CN1809557B (zh) * 2003-04-16 2012-07-04 阿斯利康(瑞典)有限公司 化合物
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
PL2256106T3 (pl) * 2003-07-22 2015-08-31 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
EP1781653A1 (en) * 2004-07-05 2007-05-09 Astex Therapeutics Limited 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors
WO2006018662A2 (en) * 2004-08-16 2006-02-23 Prosidion Limited Aryl urea derivatives for treating obesity
JP2008526723A (ja) * 2004-12-30 2008-07-24 アステックス、セラピューティックス、リミテッド Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体
US20080161355A1 (en) * 2005-01-21 2008-07-03 Astex Therapeutics Limited Combinations of Pyrazole Kinase Inhibitors and Further Antitumor Agents
AR052559A1 (es) * 2005-01-21 2007-03-21 Astex Therapeutics Ltd Derivados de pirazol para inhibir cdk's y gsk's
EP1683796A1 (en) * 2005-01-24 2006-07-26 Schering Aktiengesellschaft Pyrazolopyridines, their preparation and their medical use
FR2947546B1 (fr) * 2009-07-03 2011-07-01 Sanofi Aventis Derives de pyrazoles, leur preparation et leur application en therapeutique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2605600C2 (ru) * 2011-01-26 2016-12-27 Санофи Амино-замещенные производные 3-гетероароиламинопропионовой кислоты и их применение в качестве фармацевтических средств

Also Published As

Publication number Publication date
PE20081162A1 (es) 2008-10-02
WO2008065282A3 (fr) 2008-07-31
CL2007003251A1 (es) 2009-08-07
CR10749A (es) 2009-07-23
US8420824B2 (en) 2013-04-16
AU2007327423B2 (en) 2012-09-06
IL198328A0 (en) 2010-02-17
TN2009000155A1 (fr) 2010-10-18
CY1116000T1 (el) 2017-01-25
NI200900078A (es) 2010-01-27
AU2007327423A1 (en) 2008-06-05
TW200829556A (en) 2008-07-16
HK1137988A1 (en) 2010-08-13
NZ576709A (en) 2011-08-26
HN2009000856A (es) 2011-10-19
EP2091920A2 (fr) 2009-08-26
EP2091920B1 (fr) 2014-10-22
DK2091920T3 (en) 2015-01-26
CA2667846A1 (fr) 2008-06-05
PL2091920T3 (pl) 2015-04-30
ZA200903560B (en) 2010-08-25
SV2009003253A (es) 2009-10-27
MA30972B1 (fr) 2009-12-01
US20110237641A1 (en) 2011-09-29
HRP20150070T1 (hr) 2015-02-27
MY147502A (en) 2012-12-14
NO20091990L (no) 2009-06-02
PE20121152A1 (es) 2012-09-07
JP5538893B2 (ja) 2014-07-02
CN101553473B (zh) 2013-06-05
ES2528385T3 (es) 2015-02-09
WO2008065282A2 (fr) 2008-06-05
BRPI0718999A2 (pt) 2014-02-25
EA019454B1 (ru) 2014-03-31
CO6190516A2 (es) 2010-08-19
DOP2009000088A (es) 2013-06-15
UA97965C2 (ru) 2012-04-10
US20090291984A1 (en) 2009-11-26
PT2091920E (pt) 2015-02-05
FR2908409A1 (fr) 2008-05-16
ECSP099312A (es) 2009-06-30
SI2091920T1 (sl) 2015-02-27
JP2010509297A (ja) 2010-03-25
AR063638A1 (es) 2009-02-04
MX2009004983A (es) 2009-05-22
US7989439B2 (en) 2011-08-02
FR2908409B1 (fr) 2009-01-09
UY30707A1 (es) 2008-07-03
US8410286B2 (en) 2013-04-02
US20110237801A1 (en) 2011-09-29
KR20090083456A (ko) 2009-08-03
CN101553473A (zh) 2009-10-07

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU