EA200900249A1 - PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS PREPARATION - Google Patents

PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS PREPARATION

Info

Publication number
EA200900249A1
EA200900249A1 EA200900249A EA200900249A EA200900249A1 EA 200900249 A1 EA200900249 A1 EA 200900249A1 EA 200900249 A EA200900249 A EA 200900249A EA 200900249 A EA200900249 A EA 200900249A EA 200900249 A1 EA200900249 A1 EA 200900249A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cellulose
preparation
pharmaceutical composition
disintegrant
methyl cellulose
Prior art date
Application number
EA200900249A
Other languages
Russian (ru)
Other versions
EA021902B1 (en
Inventor
Мари-Пьер Берлёр
Жан-Клод Шомель
Франсуа Гюйон
Жан-Жак Ори
Тьерри Кин
Жиль Ле Паллек
Элизабет Моро
Original Assignee
Бушара-Рекордати
Ассистанс Пюблик Опито Де Пари
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бушара-Рекордати, Ассистанс Пюблик Опито Де Пари filed Critical Бушара-Рекордати
Publication of EA200900249A1 publication Critical patent/EA200900249A1/en
Publication of EA021902B1 publication Critical patent/EA021902B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Твердая фармацевтическая композиция в форме желатиновых капсул, содержащая, по меньшей мере, одно действующее начало, а также по меньшей мере один гелеобразователь, выбранный из числа производных целлюлозы, таких как гидроксиэтилцеллюлоза, гидроксипропилцеллюлоза, гидроксипропилметилцеллюлоза, метилцеллюлоза, этилметилцеллюлоза, натриевая соль карбоксиметилцеллюлозы (CMC) и кальциевая соль карбоксиметилцеллюлозы, и по меньшей мере один разрыхлитель, при этом гелеобразователь и разрыхлитель присутствуют в массовом соотношении от 0,3 до 0,7/1, и массовая доля гелеобразователя(ей) составляет от 10 до 20% композиции, и способ ее приготовления.A solid gelatin capsule pharmaceutical composition comprising at least one active principle and at least one gelling agent selected from cellulose derivatives such as hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, ethyl methyl cellulose, CM carboxymethyl sodium salt and a calcium salt of carboxymethyl cellulose, and at least one disintegrant, wherein the gel former and disintegrant are present in a weight ratio of 0.3 d 0.7 / 1, and the weight fraction of the gelling agent (s) is from 10 to 20% of the composition and the method of its preparation.

EA200900249A 2006-07-28 2007-07-25 Solid pharmaceutical composition forming gel in the presence of water and solid capsule containing it EA021902B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0606956A FR2904225B1 (en) 2006-07-28 2006-07-28 PHARMACEUTICAL COMPOSITIONS OF ACTIVE SUBSTANCES DIFFICULTY OF THE ROUTE OF ADMINISTRATION TO WHICH THEY ARE INTENDED
PCT/FR2007/051724 WO2008012474A2 (en) 2006-07-28 2007-07-25 Pharmaceutical compositions of active substances difficult to improperly divert from their intended route of administration

Publications (2)

Publication Number Publication Date
EA200900249A1 true EA200900249A1 (en) 2009-06-30
EA021902B1 EA021902B1 (en) 2015-09-30

Family

ID=37776622

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900249A EA021902B1 (en) 2006-07-28 2007-07-25 Solid pharmaceutical composition forming gel in the presence of water and solid capsule containing it

Country Status (14)

Country Link
US (1) US20100015219A1 (en)
EP (1) EP2046301B1 (en)
CY (1) CY1118290T1 (en)
DK (1) DK2046301T3 (en)
EA (1) EA021902B1 (en)
ES (1) ES2605018T3 (en)
FR (1) FR2904225B1 (en)
HU (1) HUE031339T2 (en)
LT (1) LT2046301T (en)
PL (1) PL2046301T3 (en)
PT (1) PT2046301T (en)
SI (1) SI2046301T1 (en)
UA (1) UA94275C2 (en)
WO (1) WO2008012474A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
PE20142320A1 (en) * 2012-03-02 2015-01-16 Rhodes Pharmaceuticals Lp IMMEDIATE RELEASE FORMULATIONS RESISTANT TO HANDLING
IT201600122469A1 (en) 2016-12-02 2018-06-02 E Pharma Trento S P A Abuse-proof solid pharmaceutical composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530563C2 (en) * 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgesic drugs with reduced potential for abuse
FR2787715B1 (en) * 1998-12-23 2002-05-10 Synthelabo PHARMACEUTICAL COMPOSITION COMPRISING A HYPNOTIC COMPOUND OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS
US20020035188A1 (en) * 2000-07-21 2002-03-21 Steeghs Henricus Renier Gerardus Agglomerating particulate materials
US20040126428A1 (en) * 2001-11-02 2004-07-01 Lyn Hughes Pharmaceutical formulation including a resinate and an aversive agent
DE10209979A1 (en) * 2002-03-07 2003-09-25 Ratiopharm Gmbh Medicines with cholesterol-lowering active substances with delayed active substance release
US20050165038A1 (en) * 2004-01-22 2005-07-28 Maxwell Gordon Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects
US20060110327A1 (en) * 2004-11-24 2006-05-25 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products

Also Published As

Publication number Publication date
LT2046301T (en) 2017-01-25
FR2904225B1 (en) 2010-08-13
PT2046301T (en) 2016-12-13
SI2046301T1 (en) 2017-02-28
WO2008012474A3 (en) 2008-03-27
HUE031339T2 (en) 2017-06-28
FR2904225A1 (en) 2008-02-01
EA021902B1 (en) 2015-09-30
PL2046301T3 (en) 2017-03-31
DK2046301T3 (en) 2017-01-02
ES2605018T3 (en) 2017-03-10
UA94275C2 (en) 2011-04-26
CY1118290T1 (en) 2017-06-28
US20100015219A1 (en) 2010-01-21
EP2046301A2 (en) 2009-04-15
WO2008012474A2 (en) 2008-01-31
EP2046301B1 (en) 2016-09-14

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