EA200870497A1 - Бензимидазольные модуляторы vr1 - Google Patents

Бензимидазольные модуляторы vr1

Info

Publication number
EA200870497A1
EA200870497A1 EA200870497A EA200870497A EA200870497A1 EA 200870497 A1 EA200870497 A1 EA 200870497A1 EA 200870497 A EA200870497 A EA 200870497A EA 200870497 A EA200870497 A EA 200870497A EA 200870497 A1 EA200870497 A1 EA 200870497A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzimidazole
modulators
compounds
benzimidazole modulators
formula
Prior art date
Application number
EA200870497A
Other languages
English (en)
Other versions
EA019386B1 (ru
Inventor
Рауль Р. Кальво
Марк Р. Плейер
Скотт Л. Дакс
Уилльям Х. Парсонс
Майкл Брандт
Шармила Пател
Цзянь Лю
Винг С. Чэунг
Мишель С. Джеттер
Юй-Кай Ли
Марк А. Янгман
Вэньси Пан
Кеннет М. Уэллс
Дерек А. Бошам
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200870497A1 publication Critical patent/EA200870497A1/ru
Publication of EA019386B1 publication Critical patent/EA019386B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретение относится к соединениям формулы (I), где R, R, R, R, R, p, q, r, L и Aявляются такими, как определено в данном описании, к фармацевтическим композициям, содержащим такие соединения, и к способам лечения заболеваний, опосредованных VR1 ионным каналом, с их использованием.
EA200870497A 2006-05-03 2007-04-17 Бензимидазольные модуляторы vr1 EA019386B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79750406P 2006-05-03 2006-05-03
PCT/US2007/066748 WO2007130780A2 (en) 2006-05-03 2007-04-17 Benzimidazole modulators of vr1

Publications (2)

Publication Number Publication Date
EA200870497A1 true EA200870497A1 (ru) 2009-06-30
EA019386B1 EA019386B1 (ru) 2014-03-31

Family

ID=38566108

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870497A EA019386B1 (ru) 2006-05-03 2007-04-17 Бензимидазольные модуляторы vr1

Country Status (37)

Country Link
US (3) US7951829B2 (ru)
EP (1) EP2021330B1 (ru)
JP (1) JP5302884B2 (ru)
KR (1) KR101434883B1 (ru)
CN (1) CN101511797B (ru)
AR (1) AR060840A1 (ru)
AT (1) ATE482201T1 (ru)
AU (1) AU2007248341C1 (ru)
BR (1) BRPI0709803B8 (ru)
CA (1) CA2651128C (ru)
CO (1) CO6160329A2 (ru)
CR (1) CR10479A (ru)
CY (1) CY1111269T1 (ru)
DE (1) DE602007009378D1 (ru)
DK (1) DK2021330T3 (ru)
EA (1) EA019386B1 (ru)
EC (1) ECSP088854A (ru)
ES (1) ES2350959T3 (ru)
HK (1) HK1131971A1 (ru)
HR (1) HRP20100700T1 (ru)
IL (1) IL194916A (ru)
JO (1) JO3602B1 (ru)
MX (1) MX2008014108A (ru)
MY (1) MY154595A (ru)
NI (1) NI200800290A (ru)
NO (1) NO341965B1 (ru)
NZ (1) NZ572251A (ru)
PE (1) PE20080065A1 (ru)
PL (1) PL2021330T3 (ru)
PT (1) PT2021330E (ru)
RS (1) RS51473B (ru)
SI (1) SI2021330T1 (ru)
TW (1) TWI419882B (ru)
UA (1) UA94749C2 (ru)
UY (1) UY30322A1 (ru)
WO (1) WO2007130780A2 (ru)
ZA (1) ZA200810234B (ru)

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KR101503286B1 (ko) * 2006-12-15 2015-03-17 얀센 파마슈티카 엔.브이. 벤즈이미다졸 ｔｒｐｖ1 저해제
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
CL2008003749A1 (es) * 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
WO2009079000A1 (en) * 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolopyrimidine modulators of trpv1
KR101252334B1 (ko) * 2008-04-18 2013-04-08 주식회사 대웅제약 신규 벤조옥사진 벤즈이미다졸 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US8232409B2 (en) 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
US8217060B2 (en) * 2009-05-15 2012-07-10 Janssen Pharmaceutica, Nv Benzimidazole derivatives useful as TRP M8 receptor modulators
US8323805B2 (en) * 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
CN102002010A (zh) * 2009-08-31 2011-04-06 住友化学株式会社 双噁唑啉基烷烃化合物的精制方法
DK2709619T3 (en) 2011-05-16 2018-01-15 Cellceutix Corp RELATIONSHIPS FOR USING THE TREATMENT OF MUCOSITIS
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
EP2970269B1 (en) 2013-03-14 2017-04-19 Novartis AG 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases
EA201690152A1 (ru) * 2013-07-11 2016-05-31 Бристол-Майерс Сквибб Компани Ингибиторы ido
EP3089963A1 (en) 2013-10-30 2016-11-09 Novartis AG 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof
WO2017043342A1 (ja) * 2015-09-08 2017-03-16 住友化学株式会社 トリアゾール化合物の製造方法
JP7041141B2 (ja) * 2016-11-01 2022-03-23 メルク・シャープ・アンド・ドーム・コーポレーション 置換された二環式ヘテロアリール系ニコチン性アセチルコリン受容体アロステリック調節剤
ES2949366T3 (es) * 2018-05-03 2023-09-28 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivados de bencimidazol como moduladores del receptor huérfano gamma relacionado con retinoides (rory) y usos farmacéuticos de los mismos
CN108997398B (zh) * 2018-07-23 2020-12-15 被忽略疾病药物研发组织 一种3,3-二甲基苯并[c][1,2]氧杂戊硼烷-1(3h)-醇的制备方法
TW202118751A (zh) * 2019-10-31 2021-05-16 大陸商江蘇恒瑞醫藥股份有限公司 RORγ調節劑的酸加成鹽
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
US11771694B2 (en) 2020-06-05 2023-10-03 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

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US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6299796B1 (en) 1997-12-18 2001-10-09 Fuji Photo Film Co., Ltd. Styryl compound, method for the preparation thereof and electroluminescent element employing the same
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KR20060115396A (ko) * 2003-10-28 2006-11-08 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서 유용한 벤즈이미다졸
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
KR20090024789A (ko) * 2006-07-04 2009-03-09 얀센 파마슈티카 엔.브이. 치환 복소환기를 갖는 벤즈이미다졸 카나비노이드 작용제
KR101503286B1 (ko) * 2006-12-15 2015-03-17 얀센 파마슈티카 엔.브이. 벤즈이미다졸 ｔｒｐｖ1 저해제

Also Published As

Publication number Publication date
EP2021330A2 (en) 2009-02-11
CA2651128A1 (en) 2007-11-15
EP2021330B1 (en) 2010-09-22
DE602007009378D1 (de) 2010-11-04
JP2009535414A (ja) 2009-10-01
IL194916A0 (en) 2009-08-03
PT2021330E (pt) 2010-12-03
AR060840A1 (es) 2008-07-16
JP5302884B2 (ja) 2013-10-02
AU2007248341B2 (en) 2011-12-08
BRPI0709803B8 (pt) 2021-05-25
US20110190344A1 (en) 2011-08-04
US20110190364A1 (en) 2011-08-04
KR20090008428A (ko) 2009-01-21
CA2651128C (en) 2014-09-02
TW200808738A (en) 2008-02-16
UA94749C2 (en) 2011-06-10
RS51473B (en) 2011-04-30
ES2350959T3 (es) 2011-01-28
PE20080065A1 (es) 2008-02-25
AU2007248341A1 (en) 2007-11-15
ZA200810234B (en) 2010-02-24
CR10479A (es) 2009-03-31
US20070259936A1 (en) 2007-11-08
PL2021330T3 (pl) 2011-03-31
DK2021330T3 (da) 2010-12-06
UY30322A1 (es) 2007-08-31
NI200800290A (es) 2012-01-30
JO3602B1 (ar) 2020-07-05
CY1111269T1 (el) 2015-08-05
TWI419882B (zh) 2013-12-21
BRPI0709803B1 (pt) 2019-12-10
HK1131971A1 (en) 2010-02-12
EA019386B1 (ru) 2014-03-31
BRPI0709803A2 (pt) 2011-07-26
NO341965B1 (no) 2018-03-05
ATE482201T1 (de) 2010-10-15
WO2007130780A3 (en) 2008-02-14
MX2008014108A (es) 2008-11-14
CO6160329A2 (es) 2010-05-20
NZ572251A (en) 2010-08-27
AU2007248341C1 (en) 2013-01-17
WO2007130780A2 (en) 2007-11-15
US7951829B2 (en) 2011-05-31
SI2021330T1 (sl) 2011-01-31
CN101511797A (zh) 2009-08-19
MY154595A (en) 2015-06-30
ECSP088854A (es) 2008-11-27
NO20085031L (no) 2009-01-06
HRP20100700T1 (hr) 2011-02-28
IL194916A (en) 2013-01-31
KR101434883B1 (ko) 2014-08-27
CN101511797B (zh) 2013-01-02

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