EA200801729A1 - Солюбилизация и нацеленная доставка препаратов с самособирающимися амфифильными полимерами - Google Patents

Солюбилизация и нацеленная доставка препаратов с самособирающимися амфифильными полимерами

Info

Publication number
EA200801729A1
EA200801729A1 EA200801729A EA200801729A EA200801729A1 EA 200801729 A1 EA200801729 A1 EA 200801729A1 EA 200801729 A EA200801729 A EA 200801729A EA 200801729 A EA200801729 A EA 200801729A EA 200801729 A1 EA200801729 A1 EA 200801729A1
Authority
EA
Eurasian Patent Office
Prior art keywords
drugs
solubilization
self
targeted delivery
amphiphilic polymers
Prior art date
Application number
EA200801729A
Other languages
English (en)
Other versions
EA025295B1 (ru
Inventor
Энил Дайвен
Энн Луизе Онтон
Джейант Дж. Тетейк
Original Assignee
Элексел, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элексел, Инк. filed Critical Элексел, Инк.
Publication of EA200801729A1 publication Critical patent/EA200801729A1/ru
Publication of EA025295B1 publication Critical patent/EA025295B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
    • C08G75/02—Polythioethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/05—Alcohols; Metal alcoholates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Предложены амфифильные биоразлагаемые сополимеры, включающие гидрофильньный остов с подвесными алифатическими группами как гидрофобный компонент. Полимеры образуют молекулярные скопления наномасштаба в водных средах, имеющие гидрофобные внутренние части, способные солюбилизировать нерастворимые органические соединения, такие как препараты, витамины, красители и средства визуализации. Полимеры необязательно имеют реакционноспособные функциональные группы, которые обеспечивают точки присоединения для антител, лигандов и других нацеливающих частей, используемых при нацеленной доставке препаратов и средств визуализации.
EA200801729A 2006-01-19 2006-01-19 Амфифильные гребенчатые полимеры, фармацевтическая композиция и способы повышения растворимости веществ EA025295B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2006/001820 WO2007084126A1 (en) 2006-01-19 2006-01-19 Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers

Publications (2)

Publication Number Publication Date
EA200801729A1 true EA200801729A1 (ru) 2009-02-27
EA025295B1 EA025295B1 (ru) 2016-12-30

Family

ID=38287941

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801729A EA025295B1 (ru) 2006-01-19 2006-01-19 Амфифильные гребенчатые полимеры, фармацевтическая композиция и способы повышения растворимости веществ

Country Status (21)

Country Link
US (1) US8173764B2 (ru)
EP (1) EP1979407B1 (ru)
JP (1) JP5027157B2 (ru)
KR (1) KR101263057B1 (ru)
CN (1) CN101400730B (ru)
AP (1) AP2570A (ru)
AU (1) AU2006336311B2 (ru)
BR (1) BRPI0621291A2 (ru)
CA (1) CA2637560C (ru)
CY (1) CY1115715T1 (ru)
DK (1) DK1979407T5 (ru)
EA (1) EA025295B1 (ru)
ES (1) ES2523431T3 (ru)
HK (1) HK1127490A1 (ru)
IL (2) IL192869A (ru)
NO (1) NO338835B1 (ru)
NZ (1) NZ570484A (ru)
PL (1) PL1979407T3 (ru)
PT (1) PT1979407E (ru)
SI (1) SI1979407T1 (ru)
WO (1) WO2007084126A1 (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897170B2 (en) * 2006-08-25 2011-03-01 Boston Scientific Scimed, Inc. Medical devices having improved mechanical performance
WO2008091246A1 (en) 2007-01-22 2008-07-31 Allexcel, Inc. Self-assembling amphiphilic polymers as antiviral agents
MX341715B (es) * 2007-07-19 2016-08-23 Allexcel Inc Polímeros anfifílicos de autoensamblaje como agentes anticáncer.
JP5539993B2 (ja) 2008-09-23 2014-07-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 薬物送達のためのナノ担体
WO2010038747A1 (ja) * 2008-09-30 2010-04-08 国立大学法人大阪大学 親水性材料、医用材料および薬剤徐放材料
KR100987693B1 (ko) 2008-10-20 2010-10-13 서울대학교산학협력단 폴리(에틸렌 글리콜)-ｂ-[폴리(Ｌ-세린)-ｇ-폴리(Ｄ,Ｌ-락티드)]의 블록공중합체 및 이를 이용한 약물전달체용 나노입자의 제조 방법
AU2011360928A1 (en) 2010-11-10 2013-06-20 Battelle Memorial Institute Self-assembling polymer particle release system
US8496946B2 (en) 2011-03-10 2013-07-30 International Business Machines Corporation Antimicrobial hydrogels, methods of preparation thereof, and articles therefrom
US9642916B2 (en) 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
CN103254442B (zh) * 2013-04-28 2015-01-14 天津大学 二硫键键接的聚酯梳型接枝共聚物及其制备方法和应用
WO2016172042A1 (en) * 2015-04-18 2016-10-27 The Texas A&M University System Polymer systems and their applications in diagnostics and drug delivery
WO2017193294A1 (zh) * 2016-05-10 2017-11-16 苏州大学张家港工业技术研究院 基于聚氨基酸的功能性生物可降解纳米粒子的制备方法
WO2018053316A1 (en) 2016-09-15 2018-03-22 The Regents Of The University Of California Improved hybrid telodendrimers
CN110423355B (zh) * 2019-08-29 2021-09-14 武汉轻工大学 羧甲基化莲藕多糖-曲古霉素a轭合物的制备方法
CN113082219B (zh) * 2021-04-07 2023-02-17 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种基于π-π作用的疏水药物的增溶方法
WO2022271183A1 (en) * 2021-06-25 2022-12-29 Allexcel Inc. Self-assembling amphphlic polymers as anti-covid-19 agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5319006A (en) * 1992-11-23 1994-06-07 Arco Chemical Technology, L.P. Preparation of polyesters from polyethers by an ester-insertion process
CA2226299A1 (en) * 1995-08-11 1997-02-27 Dendritech, Inc. Hyper comb-branched polymer conjugates
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
DE19726186A1 (de) * 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
AU752942B2 (en) 1998-04-13 2002-10-03 Massachusetts Institute Of Technology Comb copolymers for regulating cell-surface interactions
US6162877A (en) * 1998-12-04 2000-12-19 Hercules Incorporated Hydrophobically modified comb copolymers
EP1063254A1 (de) 1999-06-25 2000-12-27 Technische Uni München, Klinikum rechts der Isar, Inst. für Experiment. Onkoligie und Therapieforschung Copolymere für den Transport von Nukleinsäuren in die Zelle
DE19942302A1 (de) * 1999-09-04 2001-03-08 Beiersdorf Ag Sulfonierte Kammpolymere mit ausgewähltem Lithium/Natrium-Verhältnis und Zubereitungen, insbesondere haarkosmetische Zubereitungen auf der Grundlage von solchen sulfonierten Kammpolymeren
US6521736B2 (en) 2000-09-15 2003-02-18 University Of Massachusetts Amphiphilic polymeric materials
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
EP1465598A4 (en) 2001-12-21 2006-12-20 David S Soane USE OF OLIGOMERS AND POLYMERS FOR THE SOLUBILIZATION, STABILIZATION AND SUPPLY OF MEDICAMENTS
US7018655B2 (en) * 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
GB0221942D0 (en) 2002-09-20 2002-10-30 Univ Strathclyde Drug delivery
US8349991B2 (en) 2005-04-19 2013-01-08 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
EP2171088B1 (en) * 2007-06-19 2015-10-14 Stratos Genomics Inc. High throughput nucleic acid sequencing by expansion

Also Published As

Publication number Publication date
AP2008004573A0 (en) 2008-08-31
AU2006336311A1 (en) 2007-07-26
HK1127490A1 (en) 2009-09-25
IL225205A (en) 2017-03-30
CN101400730B (zh) 2012-10-17
CA2637560A1 (en) 2007-07-26
CA2637560C (en) 2013-11-26
DK1979407T3 (en) 2014-11-03
DK1979407T5 (en) 2014-12-01
AU2006336311B2 (en) 2013-01-24
US8173764B2 (en) 2012-05-08
EP1979407A4 (en) 2010-05-26
BRPI0621291A2 (pt) 2011-12-06
NZ570484A (en) 2011-02-25
US20100260743A1 (en) 2010-10-14
JP5027157B2 (ja) 2012-09-19
IL192869A0 (en) 2009-02-11
IL192869A (en) 2013-04-30
KR20080098373A (ko) 2008-11-07
EP1979407A1 (en) 2008-10-15
EP1979407B1 (en) 2014-08-06
ES2523431T3 (es) 2014-11-25
JP2009528394A (ja) 2009-08-06
AP2570A (en) 2013-01-23
CN101400730A (zh) 2009-04-01
PT1979407E (pt) 2014-10-16
SI1979407T1 (sl) 2015-01-30
NO338835B1 (no) 2016-10-24
NO20083573L (no) 2008-10-17
KR101263057B1 (ko) 2013-05-09
EA025295B1 (ru) 2016-12-30
PL1979407T3 (pl) 2015-03-31
WO2007084126A1 (en) 2007-07-26
CY1115715T1 (el) 2017-01-25

Similar Documents

Publication Publication Date Title
EA200801729A1 (ru) Солюбилизация и нацеленная доставка препаратов с самособирающимися амфифильными полимерами
EA200900685A1 (ru) Самособирающиеся амфифильные полимеры в качестве противовирусных средств
Mokhtarzadeh et al. Bacterial-derived biopolymers: Advanced natural nanomaterials for drug delivery and tissue engineering
WO2008141110A3 (en) Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
Arpicco et al. Hyaluronic acid conjugates as vectors for the active targeting of drugs, genes and nanocomposites in cancer treatment
WO2008076333A8 (en) Polymer-drug conjugates with tether groups for controlled drug delivery
ATE465205T1 (de) Polyglutamat-aminosäure-konjugate und verfahren
MX2009011247A (es) Nanoparticulas que comprenden una ciclodextrina y una molecula biologicamente activa y sus aplicaciones.
EA200901451A1 (ru) Самособирающиеся амфифильные полимеры в качестве противоопухолевых средств
WO2008094834A3 (en) Multi-functional drug carriers
WO2008124735A3 (en) Multi-functional polyglutamate drug carriers
WO2006138380A3 (en) Amine-containing lipids and uses thereof
WO2006010083A3 (en) Biodegradable nanoparticles
WO2011079279A3 (en) Nanoconjugates and nanoconjugate formulations
EA200600877A1 (ru) Наночастицы для доставки лекарств
WO2006097558A3 (es) Nanopartículas de quitosano y polientilenglicol como sistema de administración de moléculas biológicamente activas
ATE506392T1 (de) Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen
WO2008085556A3 (en) Surfactant-free nanoparticles for drug delivery
CY1109120T1 (el) Φαρμακευτικη συνθεση βινφλουνινης που προοριζεται για παρεντερικη χορηγηση, μεθοδος παρασκευης και χρησης
WO2009070380A3 (en) Water-soluble carbon nanotube compositions for drug delivery and medical applications
MX2009006410A (es) Conjugados de polimero-oligonucleotido, proteina y/o peptido.
GB2451599A (en) Nanostructures suitable for delivery of agents
WO2008141107A8 (en) Compositions that include a hydrophobic compound and a polyamino acid conjugate
WO2008135852A3 (en) Pharmaceutical compositions comprising nanoparticles and casein
MY153244A (en) Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU