EA200800786A1 - Тетрагидроизохинолиновые и тетрагидробензоазепиновые производные в качестве igf-1r ингибиторов, способ лечения или профилактики заболеваний, при которых благоприятна деактивация igf-1r, изделие для введения производных и хемотерапевтических агентов в комбинации, фармакологический инструмент для разработки и стандартизации тест-систем - Google Patents
Тетрагидроизохинолиновые и тетрагидробензоазепиновые производные в качестве igf-1r ингибиторов, способ лечения или профилактики заболеваний, при которых благоприятна деактивация igf-1r, изделие для введения производных и хемотерапевтических агентов в комбинации, фармакологический инструмент для разработки и стандартизации тест-системInfo
- Publication number
- EA200800786A1 EA200800786A1 EA200800786A EA200800786A EA200800786A1 EA 200800786 A1 EA200800786 A1 EA 200800786A1 EA 200800786 A EA200800786 A EA 200800786A EA 200800786 A EA200800786 A EA 200800786A EA 200800786 A1 EA200800786 A1 EA 200800786A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- igf
- derivatives
- tetragidrobenzoazepinovye
- deactivation
- standardization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
Abstract
Синтезированы соединения формулы (I). Обнаружено, что они регулируют понижающим образом или ингибируют экспрессию или функцию рецептора IGF-1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71517005P | 2005-09-09 | 2005-09-09 | |
IB2005002667 | 2005-09-09 | ||
PCT/IB2006/002474 WO2007029107A1 (en) | 2005-09-09 | 2006-09-08 | Isoquinolines derivatives as igf-1r inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200800786A1 true EA200800786A1 (ru) | 2008-08-29 |
Family
ID=37460368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200800786A EA200800786A1 (ru) | 2005-09-09 | 2006-09-08 | Тетрагидроизохинолиновые и тетрагидробензоазепиновые производные в качестве igf-1r ингибиторов, способ лечения или профилактики заболеваний, при которых благоприятна деактивация igf-1r, изделие для введения производных и хемотерапевтических агентов в комбинации, фармакологический инструмент для разработки и стандартизации тест-систем |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090099133A1 (ru) |
EP (1) | EP1940796A1 (ru) |
JP (1) | JP2009507820A (ru) |
KR (1) | KR20080065591A (ru) |
AU (1) | AU2006288847A1 (ru) |
BR (1) | BRPI0616731A2 (ru) |
CA (1) | CA2621820A1 (ru) |
EA (1) | EA200800786A1 (ru) |
NO (1) | NO20081206L (ru) |
WO (1) | WO2007029107A1 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2544672A1 (en) | 2010-03-09 | 2013-01-16 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
AU2012212075A1 (en) | 2011-02-02 | 2013-07-18 | Amgen Inc. | Methods and compositons relating to inhibition of IGF-1R |
US20140045847A1 (en) * | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
US9700619B2 (en) | 2011-11-11 | 2017-07-11 | Duke University | Combination drug therapy for the treatment of solid tumors |
US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
AU2015220750B2 (en) * | 2014-02-24 | 2020-04-16 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
TR201911032T4 (tr) * | 2015-05-18 | 2019-08-21 | Tolero Pharmaceuticals Inc | Artırılmış biyoyararlanıma sahip alvocıdıb ön ilaçları. |
WO2017129763A1 (en) | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer |
WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
US11497756B2 (en) | 2017-09-12 | 2022-11-15 | Sumitomo Pharma Oncology, Inc. | Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib |
US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6337338B1 (en) * | 1998-12-15 | 2002-01-08 | Telik, Inc. | Heteroaryl-aryl ureas as IGF-1 receptor antagonists |
EP1113007A1 (en) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
SE0203746D0 (sv) * | 2002-12-18 | 2002-12-18 | Karolinska Innovations Ab | New compounds |
BRPI0418462A (pt) * | 2004-03-12 | 2007-06-05 | Analytecon Sa | derivados de tetrahidroisoquinolina e terahidrobenzazepina como inibidores igf-1r |
-
2006
- 2006-09-08 EA EA200800786A patent/EA200800786A1/ru unknown
- 2006-09-08 JP JP2008529711A patent/JP2009507820A/ja not_active Withdrawn
- 2006-09-08 BR BRPI0616731A patent/BRPI0616731A2/pt not_active IP Right Cessation
- 2006-09-08 KR KR1020087006725A patent/KR20080065591A/ko not_active Application Discontinuation
- 2006-09-08 US US11/991,531 patent/US20090099133A1/en not_active Abandoned
- 2006-09-08 AU AU2006288847A patent/AU2006288847A1/en not_active Abandoned
- 2006-09-08 CA CA002621820A patent/CA2621820A1/en not_active Abandoned
- 2006-09-08 EP EP06795449A patent/EP1940796A1/en not_active Withdrawn
- 2006-09-08 WO PCT/IB2006/002474 patent/WO2007029107A1/en active Application Filing
-
2008
- 2008-03-07 NO NO20081206A patent/NO20081206L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2009507820A (ja) | 2009-02-26 |
BRPI0616731A2 (pt) | 2016-08-23 |
CA2621820A1 (en) | 2007-03-15 |
AU2006288847A1 (en) | 2007-03-15 |
US20090099133A1 (en) | 2009-04-16 |
KR20080065591A (ko) | 2008-07-14 |
WO2007029107A1 (en) | 2007-03-15 |
EP1940796A1 (en) | 2008-07-09 |
NO20081206L (no) | 2008-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200800786A1 (ru) | Тетрагидроизохинолиновые и тетрагидробензоазепиновые производные в качестве igf-1r ингибиторов, способ лечения или профилактики заболеваний, при которых благоприятна деактивация igf-1r, изделие для введения производных и хемотерапевтических агентов в комбинации, фармакологический инструмент для разработки и стандартизации тест-систем | |
UY29479A1 (es) | Inhibidores de adn-pk | |
EA200801428A1 (ru) | Производные пиридиазинона для лечения опухолей | |
NO20073859L (no) | Pyrrolopyrazoler, potente kinaseinhibitorer | |
ATE479687T1 (de) | Kinaseinhibitoren | |
DK1483265T3 (da) | Purinderivater som kinaseinhibitorer | |
NO20061321L (no) | Kinazolinderivater som tyrosin kinase inhibitorer | |
ATE512151T1 (de) | Pyrrolotriazin-kinaseinhibitoren | |
EA200700365A1 (ru) | Производные индол-2-карбоксамидина как антагонисты nmda рецептора | |
WO2007008704A3 (en) | Melanocortin receptor ligands | |
MY146989A (en) | Kinase inhibitors | |
TW200728277A (en) | Bicyclic derivatives as P38 inhibitors | |
ATE508119T1 (de) | Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmer | |
RS53599B1 (en) | PIRIDON DERIVATIVES FOR STRESS MODULATION OF ACTIVATED PROTEIN KINASE SYSTEMS | |
DK2270008T3 (da) | 8-Heteroaryl-3-alkyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-oner som PI-3-kinaseinhibitorer | |
BRPI0412347A (pt) | 2-aminofenil-4-fenilpiridinas como inibidores de quinase | |
TW200736229A (en) | Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors | |
BRPI0615705A2 (pt) | processo para preparar um composto, e, composto | |
NO20083923L (no) | Pyrazolkinoloner er potente parp-inhibitorer | |
CY1109916T1 (el) | Βενζιμιδαζολο-θειοφαινικες ενωσεις ως plk αναστολεις | |
BRPI0518607A2 (pt) | derivados de pirrol tendo atividade antagonista de receptor crth2 | |
WO2007120333A3 (en) | Tetracyclic kinase inhibitors | |
AR058127A1 (es) | Derivados de piperidina antagonistas de cgrp, procedimientos para su preparacion asi como su uso como medicamentos | |
DK1711177T3 (da) | 1H-thieno-2,3-c-pyrazolderivater, der er egnede som kinase-I-inhibitorer | |
UA85505C2 (en) | Kinase inhibitors |