EA200800175A1 - НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB - Google Patents

НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB

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Publication number
EA200800175A1
EA200800175A1 EA200800175A EA200800175A EA200800175A1 EA 200800175 A1 EA200800175 A1 EA 200800175A1 EA 200800175 A EA200800175 A EA 200800175A EA 200800175 A EA200800175 A EA 200800175A EA 200800175 A1 EA200800175 A1 EA 200800175A1
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EA
Eurasian Patent Office
Prior art keywords
nrr
aryl
heterocycloalkyl
haloalkyl
hydroxyalkyl
Prior art date
Application number
EA200800175A
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English (en)
Other versions
EA016300B1 (ru
Inventor
Йоханн Лебан
Харальд Шмитт
Кристина Вольф
Стефано Пегораро
Андреас Вуцик
Original Assignee
4ЭсЦэ АГ
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Priority claimed from PCT/EP2005/008261 external-priority patent/WO2006032322A1/en
Application filed by 4ЭсЦэ АГ filed Critical 4ЭсЦэ АГ
Publication of EA200800175A1 publication Critical patent/EA200800175A1/ru
Publication of EA016300B1 publication Critical patent/EA016300B1/ru

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
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Abstract

Настоящее изобретение относится к соединениям общей формулы (III), или их фармацевтически приемлемым солям с кислотой или основанием, или или их фармацевтически приемлемым пролекарствам или стереоизомерам. Формула (III), где Rпредставляет собой Н, -С(O)NRR, галоген, алкил, галогеноалкил, арил, гетероарил, ОН, SH, NROR, NH, амин, алкиламин, алкокси, циклоалкил, гетероциклоалкил, гидроксиалкил или галогеноалкилокси; Rпредставляет собой Н, галоген, алкил, -C(NR)NRR, -(СН)арил, -(CH)NRR, -C(O)NRR, -N=CRR, -NRC(O)R, циклоалкил, гетероциклоалкил, галогеноалкил, гидроксиалкил, гидроксиалкиламино, алкиламино, гетероарил или арил; Rпредставляет собой галоген, алкил,-C(NR)NRR, -(СН)арил, -(CH)NRR, -C(O)NRR, -N=CRR, -NRC(O)R, циклоалкил, гетероциклоалкил, галогеноалкил, гидроксиалкил, гидроксиалкиламино, алкиламино, гетероарил или арил.
EA200800175A 2005-07-29 2006-03-15 НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB EA016300B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2005/008261 WO2006032322A1 (en) 2004-09-20 2005-07-29 NOVEL HETEROCYCLIC NF-κB INHIBITORS
PCT/EP2006/002396 WO2007016979A2 (en) 2005-07-29 2006-03-15 NOVEL HETEROCYCLIC NF-κB INHIBITORS

Publications (2)

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EA200800175A1 true EA200800175A1 (ru) 2008-08-29
EA016300B1 EA016300B1 (ru) 2012-04-30

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JP (1) JP2009502816A (ru)
KR (1) KR20080031038A (ru)
CN (1) CN101233119A (ru)
AU (1) AU2006278998A1 (ru)
BR (1) BRPI0614188A2 (ru)
CA (1) CA2617225A1 (ru)
EA (1) EA016300B1 (ru)
IL (1) IL189112A0 (ru)
NO (1) NO20081056L (ru)
NZ (2) NZ565470A (ru)
SG (1) SG172738A1 (ru)
UA (1) UA97348C2 (ru)
WO (1) WO2007016979A2 (ru)

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CA2855756A1 (en) 2011-11-29 2013-06-06 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of nf-kb for treatment of disease
JP6619731B2 (ja) * 2013-06-18 2019-12-11 ４エスツェー アクチェンゲゼルシャフト Ｄｙｒｋキナーゼ阻害剤としての２，３−ジヒドロベンゾフラン−５−イル化合物
BR112016017344B1 (pt) * 2014-01-29 2023-05-16 Ucb Biopharma Sprl Composto de heteroaril amida, sua composição farmacêutica, seu uso, e método de interferir ou de prevenir, retardar, inverter, ou inibir a agregação da proteína ou peptídeo numa célula
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

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JP2009502816A (ja) 2009-01-29
NZ565470A (en) 2010-11-26
KR20080031038A (ko) 2008-04-07
NO20081056L (no) 2008-02-28
SG172738A1 (en) 2011-07-28
CA2617225A1 (en) 2007-02-15
WO2007016979A3 (en) 2007-08-02
NZ588971A (en) 2012-06-29
UA97348C2 (en) 2012-02-10
IL189112A0 (en) 2008-08-07
BRPI0614188A2 (pt) 2011-03-15
AU2006278998A1 (en) 2007-02-15

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