EA200702292A1 - Способ разделения производных пробукола - Google Patents

Способ разделения производных пробукола

Info

Publication number
EA200702292A1
EA200702292A1 EA200702292A EA200702292A EA200702292A1 EA 200702292 A1 EA200702292 A1 EA 200702292A1 EA 200702292 A EA200702292 A EA 200702292A EA 200702292 A EA200702292 A EA 200702292A EA 200702292 A1 EA200702292 A1 EA 200702292A1
Authority
EA
Eurasian Patent Office
Prior art keywords
probucol
separation
derivatives
derivative problems
mono
Prior art date
Application number
EA200702292A
Other languages
English (en)
Inventor
М. Дэвид Вайнгартен
Крис Чэппелоу
Original Assignee
Атеродженикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атеродженикс, Инк. filed Critical Атеродженикс, Инк.
Publication of EA200702292A1 publication Critical patent/EA200702292A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring

Abstract

Даны способы отделения однозамещенных производных пробукола от смеси одно- и двузамещенных производных пробукола. В частности, даны способы отделения монокарбоксизамещенных производных пробукола от смеси моно- и дикарбоксизамещенных производных пробукола.
EA200702292A 2005-04-21 2006-04-21 Способ разделения производных пробукола EA200702292A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67400105P 2005-04-21 2005-04-21
US70583705P 2005-08-05 2005-08-05
PCT/US2006/015022 WO2006116038A2 (en) 2005-04-21 2006-04-21 Process for the separation of probucol derivatives

Publications (1)

Publication Number Publication Date
EA200702292A1 true EA200702292A1 (ru) 2008-04-28

Family

ID=37215283

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702292A EA200702292A1 (ru) 2005-04-21 2006-04-21 Способ разделения производных пробукола

Country Status (12)

Country Link
US (2) US7687659B2 (ru)
EP (1) EP1874725A4 (ru)
JP (1) JP2008538567A (ru)
KR (1) KR20080007373A (ru)
AU (1) AU2006240083A1 (ru)
BR (1) BRPI0610602A2 (ru)
CA (1) CA2606414A1 (ru)
EA (1) EA200702292A1 (ru)
IL (1) IL186350A (ru)
MX (1) MX2007013081A (ru)
SG (1) SG161305A1 (ru)
WO (1) WO2006116038A2 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1874725A4 (en) * 2005-04-21 2011-04-06 Atherogenics Inc PROCESS FOR SEPARATING PROBUCOL DERIVATIVES
WO2009002263A1 (en) * 2007-06-26 2008-12-31 Astrazeneca Ab Process for isolating mono-carboxy substituted probucol derivates

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS496295B1 (ru) * 1970-04-02 1974-02-13
FR2130975A5 (en) 1971-03-29 1972-11-10 Aries Robert Bis(4-(phenoxyalkanoyloxy)-phenylthio)alkanes - hypolipemics hypocholesterolemics
FR2133024A5 (en) 1971-04-06 1972-11-24 Aries Robert Bis-(4-nicotinoyloxyphenylthio) propanes - with hypocholesterolaemic and hypolipaemic activity
FR2134810A5 (en) 1971-04-21 1972-12-08 Aries Robert Bis-(3-alkyl-5-t-alkyl-4-(thiazole-5-carboxy)phenylthio) alcanes - - with hypocholesterolaemic and hypolipaemic activity
FR2140771A5 (en) 1971-06-07 1973-01-19 Aries Robert Tetralinyl phenoxy alkanoic esters - of bis hydroxyphenylthio alkanes, hypolipemics etc
FR2140769A5 (en) 1971-06-07 1973-01-19 Aries Robert Benzofuryloxy alkanoic derivs of probucol - hypocholesterolemic and hypolipemic agents
FR2168137A1 (en) 1972-01-17 1973-08-31 Dynachim Sarl Bis 4-hydroxyphenylthioalkane esters - with hypocholesterolaemic and hypolipaemic activities
JPH01207258A (ja) * 1988-02-12 1989-08-21 Japanese Res & Dev Assoc Bio Reactor Syst Food Ind 脱酸方法
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
CN1275596C (zh) * 1997-05-14 2006-09-20 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
CA2404044A1 (en) * 2000-04-11 2001-10-18 Atherogenics, Inc. Compounds and methods to increase plasma hdl cholesterol levels and improve hdl functionality
US6323359B1 (en) * 2000-05-02 2001-11-27 Salsbury Chemicals, Inc. Process for preparing probucol derivatives
KR20050044352A (ko) * 2001-11-09 2005-05-12 아테로제닉스, 인코포레이티드 심혈관 병리의 역전 및 예방 방법
JP4467429B2 (ja) * 2002-07-12 2010-05-26 アセロジエニクス・インコーポレイテツド 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態
CN100548950C (zh) * 2003-01-13 2009-10-14 阿特罗吉尼克斯公司 制备普罗布考及其衍生物的酯和醚的方法
US20060025481A1 (en) * 2004-02-09 2006-02-02 Strange Matthew L Process for preparation of probucol derivatives and polymorphic forms thereof
US7809540B2 (en) * 2004-02-24 2010-10-05 Aspen Technology, Inc. Computer method and system for predicting physical properties using a conceptual segment-based ionic activity coefficient model
US7294736B2 (en) * 2004-04-09 2007-11-13 Cambrex Charles City, Inc. Process for preparation of probucol derivatives
WO2005102323A2 (en) * 2004-04-20 2005-11-03 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
EP1874725A4 (en) * 2005-04-21 2011-04-06 Atherogenics Inc PROCESS FOR SEPARATING PROBUCOL DERIVATIVES

Also Published As

Publication number Publication date
US20060258883A1 (en) 2006-11-16
SG161305A1 (en) 2010-05-27
EP1874725A4 (en) 2011-04-06
JP2008538567A (ja) 2008-10-30
AU2006240083A1 (en) 2006-11-02
US7687659B2 (en) 2010-03-30
KR20080007373A (ko) 2008-01-18
IL186350A0 (en) 2008-01-20
MX2007013081A (es) 2008-01-18
US20100174108A1 (en) 2010-07-08
WO2006116038A3 (en) 2006-12-07
IL186350A (en) 2012-08-30
CA2606414A1 (en) 2006-11-02
BRPI0610602A2 (pt) 2010-07-06
EP1874725A2 (en) 2008-01-09
WO2006116038A2 (en) 2006-11-02

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