EA200501376A1 - DERIVATIVES OF 1,2,4-SUBSTITUTED 1,2,3,4-TETRAHYDRO- and 1,2-DIHYDROCHINOLINES AND 1,2,3,4-TETRAHYDROCHINOXALINE AS AN INHIBITORS CETR FOR THE TREATMENT OF ATHEROSCLEROSIS AND FAT - Google Patents

DERIVATIVES OF 1,2,4-SUBSTITUTED 1,2,3,4-TETRAHYDRO- and 1,2-DIHYDROCHINOLINES AND 1,2,3,4-TETRAHYDROCHINOXALINE AS AN INHIBITORS CETR FOR THE TREATMENT OF ATHEROSCLEROSIS AND FAT

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Publication number
EA200501376A1
EA200501376A1 EA200501376A EA200501376A EA200501376A1 EA 200501376 A1 EA200501376 A1 EA 200501376A1 EA 200501376 A EA200501376 A EA 200501376A EA 200501376 A EA200501376 A EA 200501376A EA 200501376 A1 EA200501376 A1 EA 200501376A1
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EA
Eurasian Patent Office
Prior art keywords
atherosclerosis
levels
cholesterol
tetrahydrochinoxaline
dihydrochinolines
Prior art date
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EA200501376A
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Russian (ru)
Inventor
Джордж Чанг
Мари Тереза Дидиук
Яри Илмари Финнеман
Рави Шанкер Гаригипати
Райан Майкл Келли
Дэвид Остен Перри
Роджер Бенджамин Руггери
Брюс Майкл Бекле
Майкл П. Полластри
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Пфайзер Продактс Инк.
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Publication of EA200501376A1 publication Critical patent/EA200501376A1/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Соединения хинолина и хиноксалина формул I и III, где заместители имеют указанные в пп.1 и 15 значения, фармацевтические композиции, содержащие указанные соединения, и применение указанных соединений для повышения уровней содержания некоторых липидов в плазме, включая липопротеин-холестерин высокой плотности, и для снижения уровней содержания некоторых других липидов в плазме, таких как LDL-холестерин и триглицериды, и соответственно для лечения заболеваний, которые обостряются из-за низких уровней HDL-холестерина и/или высоких уровней LDL-холестерина и триглицеридов, таких как атеросклероз и сердечно-сосудистые заболевания у некоторых млекопитающих, включая людей.The quinoline and quinoxaline compounds of formulas I and III, where the substituents have the meanings indicated in claims 1 and 15, pharmaceutical compositions containing these compounds, and the use of these compounds to increase the levels of certain plasma lipids, including high-density lipoprotein-cholesterol, and for lowering levels of some other plasma lipids, such as LDL-cholesterol and triglycerides, and accordingly for treating diseases that are exacerbated by low levels of HDL-cholesterol and / or high levels of LDL-choles sterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

EA200501376A 2003-03-28 2004-03-15 DERIVATIVES OF 1,2,4-SUBSTITUTED 1,2,3,4-TETRAHYDRO- and 1,2-DIHYDROCHINOLINES AND 1,2,3,4-TETRAHYDROCHINOXALINE AS AN INHIBITORS CETR FOR THE TREATMENT OF ATHEROSCLEROSIS AND FAT EA200501376A1 (en)

Applications Claiming Priority (2)

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US45827403P 2003-03-28 2003-03-28
PCT/IB2004/000836 WO2004085401A1 (en) 2003-03-28 2004-03-15 1,2,4-substituted 1,2,3,4-tetrahydro-and 1,2 dihydro-quinoline and 1,2,3,4-tetrahydro-quinoxaline derivatives as cetp inhibitors for the treatment of atherosclerosis and obesity

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EP (1) EP1622872A1 (en)
JP (1) JP2006521344A (en)
KR (1) KR100729883B1 (en)
CN (1) CN1795177A (en)
AR (1) AR044507A1 (en)
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EP2287166A3 (en) 2003-07-14 2011-06-22 Arena Pharmaceuticals, Inc. Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
WO2006033001A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds
WO2006033004A1 (en) * 2004-09-23 2006-03-30 Pfizer Products Inc. Quinoline compounds as cetp inhibitors
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