EA200500169A1 - SUBSTITUTED DERIVATIVES 1,3-DIPHENYLPROP-2-EN-1-SHE, RECEIVING AND APPLICATION - Google Patents
SUBSTITUTED DERIVATIVES 1,3-DIPHENYLPROP-2-EN-1-SHE, RECEIVING AND APPLICATIONInfo
- Publication number
- EA200500169A1 EA200500169A1 EA200500169A EA200500169A EA200500169A1 EA 200500169 A1 EA200500169 A1 EA 200500169A1 EA 200500169 A EA200500169 A EA 200500169A EA 200500169 A EA200500169 A EA 200500169A EA 200500169 A1 EA200500169 A1 EA 200500169A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- diphenylprop
- application
- receiving
- substituted derivatives
- derivatives
- Prior art date
Links
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- DQFBYFPFKXHELB-VAWYXSNFSA-N trans-chalcone Chemical class C=1C=CC=CC=1C(=O)\C=C\C1=CC=CC=C1 DQFBYFPFKXHELB-VAWYXSNFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Abstract
Настоящее изобретение относится к новым замещенным производным 1,3-дифенилпроп-2-ен-1-она, к содержащим их фармацевтическим композициям, их применению в терапии, в частности для лечения ишемии мозга. Оно также относится к способу получения этих производных.Международная заявка была опубликована вместе с отчетом о международном поиске.The present invention relates to novel substituted 1,3-diphenylprop-2-en-1-one derivatives, to pharmaceutical compositions containing them, their use in therapy, in particular for the treatment of brain ischemia. It also refers to the method of obtaining these derivatives. The international application was published along with an international search report.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0208571A FR2841900B1 (en) | 2002-07-08 | 2002-07-08 | NOVEL SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES, PREPARATION AND USES |
PCT/FR2003/002127 WO2004005233A1 (en) | 2002-07-08 | 2003-07-08 | Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500169A1 true EA200500169A1 (en) | 2005-06-30 |
EA011090B1 EA011090B1 (en) | 2008-12-30 |
Family
ID=29725283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200500169A EA011090B1 (en) | 2002-07-08 | 2003-07-08 | Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof |
Country Status (24)
Country | Link |
---|---|
US (3) | US7943661B2 (en) |
EP (1) | EP1525177B1 (en) |
JP (1) | JP4575771B2 (en) |
KR (1) | KR100974577B1 (en) |
CN (1) | CN100548960C (en) |
AT (1) | ATE365703T1 (en) |
AU (1) | AU2003264698B2 (en) |
BR (1) | BRPI0312398B8 (en) |
CA (1) | CA2490986C (en) |
CY (1) | CY1108085T1 (en) |
DE (1) | DE60314633T2 (en) |
DK (1) | DK1525177T3 (en) |
EA (1) | EA011090B1 (en) |
ES (1) | ES2287528T3 (en) |
FR (1) | FR2841900B1 (en) |
IL (2) | IL165696A0 (en) |
MX (1) | MXPA05000427A (en) |
NO (1) | NO329700B1 (en) |
NZ (1) | NZ538051A (en) |
PL (1) | PL207362B1 (en) |
PT (1) | PT1525177E (en) |
SI (1) | SI1525177T1 (en) |
WO (1) | WO2004005233A1 (en) |
ZA (1) | ZA200501082B (en) |
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FR2841900B1 (en) | 2002-07-08 | 2007-03-02 | Genfit S A | NOVEL SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES, PREPARATION AND USES |
FR2841784B1 (en) | 2002-07-08 | 2007-03-02 | COMPOSITION BASED ON SUBSTITUTED 1,3-DIPHENYLPROP-2EN-1-ONE DERIVATIVES, PREPARATION AND USES | |
JP2007517841A (en) * | 2004-01-08 | 2007-07-05 | ジェンフィット | 1,3-diphenylprop-2-en-1-one derivative compound, process for its preparation and use thereof |
FR2902789A1 (en) | 2006-06-21 | 2007-12-28 | Genfit Sa | SUBSTITUTED 1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES |
US20100285126A1 (en) * | 2007-08-02 | 2010-11-11 | Rahul Dabre | Pharmaceutical compositions of fenofibrate |
US10722575B2 (en) | 2009-11-26 | 2020-07-28 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
US9221751B2 (en) | 2009-11-26 | 2015-12-29 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
HUE039731T2 (en) * | 2009-11-26 | 2019-01-28 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
WO2011080276A1 (en) | 2009-12-29 | 2011-07-07 | Genfit | Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative |
SI2571843T1 (en) | 2010-05-17 | 2018-04-30 | Genfit | Improved preparation of chalcone derivatives |
TWI415600B (en) * | 2011-08-10 | 2013-11-21 | Univ Kaohsiung Medical | Composition for treating atherosclerosis and a preparation method thereof |
BR112014016129B1 (en) | 2011-12-28 | 2022-04-05 | Genfit | Compound, 1,3-diphenylpropane derivative and pharmaceutical composition |
CN102697757B (en) * | 2012-05-18 | 2014-06-04 | ***广州总医院 | Application of p-hydroxy benzylidene acetone in preparation of drugs for preventing and/or treating encephalopathy |
DK2948137T3 (en) | 2013-01-18 | 2019-01-07 | Genfit | METHODS OF TREATING FIBROSE AND CANCER TYPES |
WO2017143038A1 (en) * | 2016-02-16 | 2017-08-24 | Concert Pharmaceuticals, Inc. | Deuterated gft-505 |
CN109152756B (en) | 2016-03-31 | 2022-05-17 | 基恩菲特公司 | Methods of treating cholestatic diseases |
FR3056909B1 (en) * | 2016-09-30 | 2019-04-19 | Nashpharm | COMPOSITION COMPRISING AT LEAST ONE PHARMACEUTICALLY ACCEPTABLE SALT OF SOLUBLE ELAFIBRANOR IN AQUEOUS MEDIA HAVING IMPROVED INTESTINAL ABSORPTION |
FR3056908B1 (en) * | 2016-09-30 | 2019-04-19 | Nashpharm | METFORMIN AND ELAFIBRANOR SALT HAVING DUAL ACTIVITY FOR THE TREATMENT OF OBESITY ASSOCIATED WITH NON-ALCOHOLIC STEATO-HEPATITIS (NASH) AND HYPERTRIGLYCERIDEMIA |
WO2018112037A1 (en) * | 2016-12-16 | 2018-06-21 | Jia Zhou | Inhibitors of bromodomain-containing protein 4 (brd4) |
EP3572399A4 (en) * | 2017-01-22 | 2020-01-22 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Crystal form of gft-505 and preparation method and use thereof |
CA3051776A1 (en) | 2017-02-21 | 2018-08-30 | Genfit | Combination therapy |
CA3051977A1 (en) | 2017-02-24 | 2018-08-30 | Genfit | Pharmaceutical compositions for combination therapy |
KR20190136079A (en) | 2017-04-18 | 2019-12-09 | 장피트 | Combination comprising a PPAR agonist such as elapifinor and acetyl-COA carboxylase (ACC) inhibitor |
CN108658908B (en) * | 2017-07-31 | 2019-05-10 | 广州必贝特医药技术有限公司 | 1,3- bis- replaces ketene compounds and its application |
BR112020002261A2 (en) | 2017-08-04 | 2020-07-28 | Advitech Advisory And Technologies Sa | process for the preparation of elafibranor, compound and use of at least one compound |
EP3681537A1 (en) | 2017-09-13 | 2020-07-22 | Novartis AG | Combinations comprising fxr agonists |
EP3710425A1 (en) | 2017-11-16 | 2020-09-23 | Teva Pharmaceuticals International GmbH | Solid state forms of elafibranor |
WO2019105234A1 (en) | 2017-11-30 | 2019-06-06 | 四川科伦博泰生物医药股份有限公司 | Aromatic compound, pharmaceutical composition thereof and use thereof |
EP3514541A1 (en) * | 2018-01-17 | 2019-07-24 | Siemens Healthcare Diagnostics Products GmbH | Method of quantitative determination of a therapeutical tnf-alpha inhibitor |
WO2019186410A1 (en) * | 2018-03-27 | 2019-10-03 | Lupin Limited | Solid forms of elafibranor and processes thereof |
EP3830070A1 (en) * | 2018-08-03 | 2021-06-09 | Genfit | Elafibranor salts |
WO2020039297A1 (en) * | 2018-08-24 | 2020-02-27 | Mankind Pharma Ltd. | Novel compounds and their use in preparation of elafibranor and pharmaceutical acceptable salts thereof |
WO2020115628A1 (en) * | 2018-12-03 | 2020-06-11 | Mankind Pharma Ltd. | Solid forms of elafibranor and process of preparation thereof |
CN110156648A (en) * | 2019-05-30 | 2019-08-23 | 河北科技大学 | A kind of preparation method of Elafibranor intermediate |
CA3153784A1 (en) | 2019-10-28 | 2021-05-06 | Nicolas STANKOVIC-VALENTIN | Combination therapy having antioxydant properties |
CN112824380A (en) * | 2019-11-21 | 2021-05-21 | 杭州百诚医药科技股份有限公司 | Alpha-fluoro chalcone derivative and application thereof |
CN111138264B (en) * | 2019-11-29 | 2023-08-04 | 温州医科大学 | Syringaldehyde derivative and application thereof in preparing anti-gynecological tumor drugs |
CN113121394B (en) * | 2019-12-30 | 2022-11-08 | 中国药科大学 | Preparation method of phenoxyacetic acid derivative |
CA3163583A1 (en) | 2020-02-10 | 2021-08-19 | Genfit | Polymorphs of elafibranor |
JP2023526410A (en) | 2020-05-18 | 2023-06-21 | ジェンフィット | Elafibranol for the treatment of primary sclerosing cholangitis |
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CN114853686B (en) | 2021-08-23 | 2023-06-20 | 中国药科大学 | Triazolone compound and medical application thereof |
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FR2841900B1 (en) | 2002-07-08 | 2007-03-02 | Genfit S A | NOVEL SUBSTITUTED 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES, PREPARATION AND USES |
FR2841784B1 (en) * | 2002-07-08 | 2007-03-02 | COMPOSITION BASED ON SUBSTITUTED 1,3-DIPHENYLPROP-2EN-1-ONE DERIVATIVES, PREPARATION AND USES | |
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JP2007517841A (en) * | 2004-01-08 | 2007-07-05 | ジェンフィット | 1,3-diphenylprop-2-en-1-one derivative compound, process for its preparation and use thereof |
-
2002
- 2002-07-08 FR FR0208571A patent/FR2841900B1/en not_active Expired - Fee Related
-
2003
- 2003-07-08 ES ES03762749T patent/ES2287528T3/en not_active Expired - Lifetime
- 2003-07-08 KR KR1020057000349A patent/KR100974577B1/en active IP Right Grant
- 2003-07-08 US US10/520,079 patent/US7943661B2/en active Active
- 2003-07-08 IL IL16569603A patent/IL165696A0/en unknown
- 2003-07-08 AT AT03762749T patent/ATE365703T1/en active
- 2003-07-08 JP JP2004518890A patent/JP4575771B2/en not_active Expired - Lifetime
- 2003-07-08 BR BRPI0312398A patent/BRPI0312398B8/en active IP Right Grant
- 2003-07-08 SI SI200330864T patent/SI1525177T1/en unknown
- 2003-07-08 MX MXPA05000427A patent/MXPA05000427A/en active IP Right Grant
- 2003-07-08 DE DE60314633T patent/DE60314633T2/en not_active Expired - Lifetime
- 2003-07-08 PL PL372809A patent/PL207362B1/en unknown
- 2003-07-08 PT PT03762749T patent/PT1525177E/en unknown
- 2003-07-08 WO PCT/FR2003/002127 patent/WO2004005233A1/en active IP Right Grant
- 2003-07-08 CN CNB038163667A patent/CN100548960C/en not_active Expired - Lifetime
- 2003-07-08 EP EP03762749A patent/EP1525177B1/en not_active Expired - Lifetime
- 2003-07-08 AU AU2003264698A patent/AU2003264698B2/en not_active Ceased
- 2003-07-08 DK DK03762749T patent/DK1525177T3/en active
- 2003-07-08 EA EA200500169A patent/EA011090B1/en not_active IP Right Cessation
- 2003-07-08 CA CA2490986A patent/CA2490986C/en not_active Expired - Fee Related
- 2003-07-08 NZ NZ538051A patent/NZ538051A/en not_active IP Right Cessation
-
2004
- 2004-12-03 NO NO20045301A patent/NO329700B1/en not_active IP Right Cessation
- 2004-12-09 IL IL165696A patent/IL165696A/en active IP Right Grant
-
2005
- 2005-02-07 ZA ZA200501082A patent/ZA200501082B/en unknown
-
2006
- 2006-07-26 US US11/493,040 patent/US7566737B2/en not_active Expired - Lifetime
-
2007
- 2007-08-03 CY CY20071101040T patent/CY1108085T1/en unknown
-
2011
- 2011-04-11 US US13/083,659 patent/US8058308B2/en not_active Expired - Lifetime
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