EA200000310A1 - April - новый белок, воздействующий на рост - Google Patents
April - новый белок, воздействующий на ростInfo
- Publication number
- EA200000310A1 EA200000310A1 EA200000310A EA200000310A EA200000310A1 EA 200000310 A1 EA200000310 A1 EA 200000310A1 EA 200000310 A EA200000310 A EA 200000310A EA 200000310 A EA200000310 A EA 200000310A EA 200000310 A1 EA200000310 A1 EA 200000310A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- april
- growth
- new protein
- protein impact
- impact
- Prior art date
Links
- 102100039097 Protein IMPACT Human genes 0.000 title 1
- 101710183393 Protein IMPACT Proteins 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
APRIL, новый член семейства факторов некроза опухолей (TNF), модифицированные формы APRIL и содержащие их фармацевтические композиции.Отчет о международном поиске был опубликован 1999.06.03.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5878697P | 1997-09-12 | 1997-09-12 | |
US7938498P | 1998-03-26 | 1998-03-26 | |
PCT/US1998/019191 WO1999012965A2 (en) | 1997-09-12 | 1998-09-11 | April- a novel protein with growth effects |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200000310A1 true EA200000310A1 (ru) | 2000-10-30 |
EA005411B1 EA005411B1 (ru) | 2005-02-24 |
Family
ID=26738027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000310A EA005411B1 (ru) | 1997-09-12 | 1998-09-11 | Применение антитела против полипептида april для получения лекарственного препарата для лечения опухолей |
Country Status (20)
Country | Link |
---|---|
US (3) | US20030138884A1 (ru) |
EP (1) | EP1027431A2 (ru) |
JP (1) | JP2001515712A (ru) |
KR (1) | KR100618492B1 (ru) |
CN (1) | CN1195849C (ru) |
AU (1) | AU759717B2 (ru) |
BR (1) | BR9812634A (ru) |
CA (1) | CA2303615A1 (ru) |
CZ (1) | CZ294615B6 (ru) |
EA (1) | EA005411B1 (ru) |
EE (1) | EE200000147A (ru) |
HU (1) | HUP0004611A3 (ru) |
IL (1) | IL134537A0 (ru) |
IS (1) | IS5378A (ru) |
NO (1) | NO20001242L (ru) |
NZ (1) | NZ503850A (ru) |
PL (1) | PL339463A1 (ru) |
SK (1) | SK3542000A3 (ru) |
TR (1) | TR200000669T2 (ru) |
WO (1) | WO1999012965A2 (ru) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6541224B2 (en) | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
US7217788B2 (en) | 1996-03-14 | 2007-05-15 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta polypeptides |
AU1700999A (en) * | 1997-11-26 | 1999-06-15 | Eli Lilly And Company | Tnf ligand family gene |
US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
EP1415659B9 (en) | 1999-01-25 | 2012-02-15 | Biogen Idec MA Inc. | An antibody specific for soluble BAFF for use in the treatment of cancer |
US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
KR20090016772A (ko) | 1999-08-17 | 2009-02-17 | 바이오겐 아이덱 엠에이 인코포레이티드 | Baff 수용체(bcma), 면역조절제 |
WO2001025256A2 (en) * | 1999-10-06 | 2001-04-12 | University Of Utah Research Foundation | Trdl-1-gamma, a novel tumor necrosis-like ligand |
UA74798C2 (ru) * | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Способ лечения рака у млекопитающих с помощью полипептида, который препятствует взаимодействию между april и его рецепторами |
CA2897626C (en) | 2000-02-11 | 2020-03-24 | Biogen Idec Ma Inc. | Heterologous polypeptide of the tnf family |
AU2006201471B2 (en) * | 2000-02-16 | 2009-07-23 | Genentech, Inc. | Uses of agonists and antagonists to modulate activity of TNF-related molecules |
DE60028830T2 (de) * | 2000-02-16 | 2007-01-18 | Genentech, Inc., South San Francisco | Anti-april antikörper und hybridomazellen |
EP1280826B1 (en) * | 2000-05-12 | 2007-05-02 | Amgen Inc. | Polypeptides for inhibiting april-mediated b- and t-cell proliferation. |
EP2431054A3 (en) * | 2000-06-15 | 2013-03-06 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
UA83458C2 (ru) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Выделенный полипептид baff-r (рецептор фактора активации в-клеток семейства tnf) |
GB2370273A (en) * | 2000-12-20 | 2002-06-26 | Viaxxel Biotech Gmbh | Compounds that affect CD83 expression |
JP2004537290A (ja) | 2001-05-24 | 2004-12-16 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 腫瘍壊死因子δ(APRIL)に対する抗体 |
EA007275B1 (ru) | 2001-05-24 | 2006-08-25 | Займодженетикс, Инк. | Слитые белки taci-иммуноглобулина |
CA2472049A1 (en) | 2002-01-04 | 2003-07-17 | Xencor | Dominant negative proteins and methods thereof |
US7381792B2 (en) | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
WO2004089982A2 (en) * | 2003-01-06 | 2004-10-21 | Xencor | April variants and methods thereof |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
JP5524441B2 (ja) | 2003-03-28 | 2014-06-18 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 短縮されたbaffレセプター |
CA2554526A1 (en) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants of the extracellular domain of bcma and uses thereof |
US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
WO2005113598A2 (en) * | 2004-05-21 | 2005-12-01 | Xencor, Inc. | Tnf super family members with altered immunogenicity |
CA2590461A1 (en) | 2004-12-23 | 2006-06-29 | Laboratoires Serono S.A. | Bcma polypeptides and uses thereof |
KR20080056714A (ko) | 2005-08-09 | 2008-06-23 | 지모제넥틱스, 인코포레이티드 | TACI―Ig 융합 분자를 사용하여 B―세포 악성종양을치료하는 방법 |
WO2007019573A2 (en) | 2005-08-09 | 2007-02-15 | Zymogenetics, Inc. | Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules |
EP1934258B1 (en) * | 2005-09-26 | 2011-03-02 | Enzo Life Sciences (ELS) AG | Antibodies against april as biomarkers for early prognosis of lymphoma patients |
US20070086979A1 (en) | 2005-10-13 | 2007-04-19 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
US9726673B2 (en) | 2005-11-23 | 2017-08-08 | Genentech, Inc. | Methods and compositions related to B cell assays |
BRPI0711823A2 (pt) | 2006-05-15 | 2012-01-17 | Ares Trading Sa | métodos para tratamento de doenças auto-imunes com uma molécula de fusão taci-ig |
ES2928709T3 (es) | 2009-03-02 | 2022-11-22 | Aduro Biotech Holdings Europe B V | Anticuerpos frente a un ligando inductor de proliferación (APRIL) |
WO2011109280A1 (en) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Methods and compositions to treat immune-mediated disorders |
EP2542679A1 (en) * | 2010-03-05 | 2013-01-09 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | B-cell stimulating fusion proteins of an antigen with baff or april |
NL2011406C2 (en) * | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
SI3175706T1 (sl) * | 2013-09-23 | 2019-03-29 | Regeneron Pharmaceuticals, Inc. | Nehumane živali s humaniziranim genom signal-regulatornega proteina |
GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
AU2014353347B2 (en) * | 2013-11-19 | 2020-07-02 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
EP4285923A3 (en) | 2015-11-25 | 2024-03-06 | Visterra, Inc. | Antibody molecules to april and uses thereof |
US11484027B2 (en) | 2020-10-29 | 2022-11-01 | Industrial Polymers and Chemicals, Inc. | Air filter with pathogen monitoring and inactivation |
WO2023019223A2 (en) | 2021-08-11 | 2023-02-16 | Akso Biopharmaceutical Inc. | METHODS OF REDUCING PRODUCTION OF IgA, IgM AND/OR IgG USING sBCMA VARIANTS AND FC FUSION PROTEINS THEREOF |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5256775A (en) * | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
US5264564A (en) * | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
AU6166396A (en) * | 1995-06-07 | 1996-12-30 | Biogen, Inc. | Complexes of modified lymphotoxins as pharmaceutical prepara tions |
ATE254135T1 (de) * | 1996-03-14 | 2003-11-15 | Human Genome Sciences Inc | Humaner tumornekrosefaktor delta und epsilon |
US6509170B1 (en) * | 1996-03-14 | 2003-01-21 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor delta |
US6171787B1 (en) * | 1997-06-26 | 2001-01-09 | Abbott Laboratories | Member of the TNF family useful for treatment and diagnosis of disease |
-
1998
- 1998-09-11 SK SK354-2000A patent/SK3542000A3/sk unknown
- 1998-09-11 EE EEP200000147A patent/EE200000147A/xx unknown
- 1998-09-11 EA EA200000310A patent/EA005411B1/ru unknown
- 1998-09-11 PL PL98339463A patent/PL339463A1/xx unknown
- 1998-09-11 JP JP2000510770A patent/JP2001515712A/ja active Pending
- 1998-09-11 CN CNB988090384A patent/CN1195849C/zh not_active Expired - Fee Related
- 1998-09-11 HU HU0004611A patent/HUP0004611A3/hu unknown
- 1998-09-11 AU AU93162/98A patent/AU759717B2/en not_active Ceased
- 1998-09-11 WO PCT/US1998/019191 patent/WO1999012965A2/en not_active Application Discontinuation
- 1998-09-11 CA CA002303615A patent/CA2303615A1/en not_active Abandoned
- 1998-09-11 TR TR2000/00669T patent/TR200000669T2/xx unknown
- 1998-09-11 BR BR9812634-2A patent/BR9812634A/pt not_active Application Discontinuation
- 1998-09-11 KR KR1020007002577A patent/KR100618492B1/ko not_active IP Right Cessation
- 1998-09-11 NZ NZ503850A patent/NZ503850A/xx unknown
- 1998-09-11 CZ CZ2000869A patent/CZ294615B6/cs not_active IP Right Cessation
- 1998-09-11 IL IL13453798A patent/IL134537A0/xx unknown
- 1998-09-11 EP EP98946066A patent/EP1027431A2/en not_active Withdrawn
-
2000
- 2000-02-18 IS IS5378A patent/IS5378A/is unknown
- 2000-03-09 NO NO20001242A patent/NO20001242L/no unknown
-
2002
- 2002-05-01 US US10/138,073 patent/US20030138884A1/en not_active Abandoned
-
2004
- 2004-02-12 US US10/778,890 patent/US20050112596A1/en not_active Abandoned
-
2005
- 2005-12-06 US US11/296,049 patent/US20060084148A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NO20001242D0 (no) | 2000-03-09 |
PL339463A1 (en) | 2000-12-18 |
SK3542000A3 (en) | 2000-08-14 |
US20050112596A1 (en) | 2005-05-26 |
WO1999012965A2 (en) | 1999-03-18 |
EP1027431A2 (en) | 2000-08-16 |
JP2001515712A (ja) | 2001-09-25 |
WO1999012965A3 (en) | 1999-06-03 |
HUP0004611A2 (hu) | 2001-04-28 |
IL134537A0 (en) | 2001-04-30 |
CA2303615A1 (en) | 1999-03-18 |
US20060084148A1 (en) | 2006-04-20 |
NZ503850A (en) | 2002-12-20 |
CZ2000869A3 (cs) | 2000-09-13 |
CN1270632A (zh) | 2000-10-18 |
EE200000147A (et) | 2001-02-15 |
IS5378A (is) | 2000-02-18 |
HUP0004611A3 (en) | 2002-04-29 |
AU9316298A (en) | 1999-03-29 |
TR200000669T2 (tr) | 2000-08-21 |
EA005411B1 (ru) | 2005-02-24 |
CZ294615B6 (cs) | 2005-02-16 |
NO20001242L (no) | 2000-05-11 |
AU759717B2 (en) | 2003-04-17 |
KR100618492B1 (ko) | 2006-08-31 |
BR9812634A (pt) | 2000-08-22 |
CN1195849C (zh) | 2005-04-06 |
US20030138884A1 (en) | 2003-07-24 |
KR20010023893A (ko) | 2001-03-26 |
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