EA200000205A1 - Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов - Google Patents
Производные пирролопирролона в качестве ингибиторов эластазы нейтрофиловInfo
- Publication number
- EA200000205A1 EA200000205A1 EA200000205A EA200000205A EA200000205A1 EA 200000205 A1 EA200000205 A1 EA 200000205A1 EA 200000205 A EA200000205 A EA 200000205A EA 200000205 A EA200000205 A EA 200000205A EA 200000205 A1 EA200000205 A1 EA 200000205A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrrolopyrlonone
- elastasis
- neutrophils
- inhibitors
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Согласно данному изобретению предложены соединения формулы (I) (показана относительная стереохимия), где R, Rи Rтакие, как указано в описании. Соединения формулы (I) полезны, кроме всего прочего, в лечении воспалительных заболеваний дыхательных путей.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9719187.8A GB9719187D0 (en) | 1997-09-09 | 1997-09-09 | Compounds |
PCT/EP1998/005604 WO1999012931A1 (en) | 1997-09-09 | 1998-09-07 | Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200000205A1 true EA200000205A1 (ru) | 2000-10-30 |
Family
ID=10818820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000205A EA200000205A1 (ru) | 1997-09-09 | 1998-09-07 | Производные пирролопирролона в качестве ингибиторов эластазы нейтрофилов |
Country Status (24)
Country | Link |
---|---|
US (1) | US6228853B1 (ru) |
EP (1) | EP1019406A1 (ru) |
JP (1) | JP2001515902A (ru) |
KR (1) | KR20010023830A (ru) |
CN (1) | CN1278821A (ru) |
AP (1) | AP2000001760A0 (ru) |
AU (1) | AU9536098A (ru) |
BR (1) | BR9811651A (ru) |
CA (1) | CA2303249A1 (ru) |
EA (1) | EA200000205A1 (ru) |
EE (1) | EE200000137A (ru) |
GB (1) | GB9719187D0 (ru) |
HR (1) | HRP20000136A2 (ru) |
HU (1) | HUP0003475A3 (ru) |
ID (1) | ID24364A (ru) |
IL (1) | IL134935A0 (ru) |
IS (1) | IS5394A (ru) |
MA (1) | MA26544A1 (ru) |
NO (1) | NO20001200L (ru) |
PL (1) | PL339186A1 (ru) |
SK (1) | SK3242000A3 (ru) |
TR (1) | TR200001026T2 (ru) |
WO (1) | WO1999012931A1 (ru) |
ZA (1) | ZA988162B (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
WO2011072163A1 (en) | 2009-12-11 | 2011-06-16 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
WO2011072152A1 (en) | 2009-12-11 | 2011-06-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry of steroidal compounds in multiplex samples |
CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
IL297211A (en) | 2020-04-16 | 2022-12-01 | Mereo Biopharma 4 Ltd | Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency |
AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3983245A (en) | 1975-02-06 | 1976-09-28 | Smithkline Corporation | Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes |
GB8512230D0 (en) * | 1985-05-14 | 1985-06-19 | Shell Internationale Researche | Preparation of carboxylic acid salt |
GB9211783D0 (en) | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
GB9402680D0 (en) | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
TR199801282T2 (xx) * | 1996-01-03 | 1998-12-21 | Smithkline Beecham P.L.C. | Mutilin'in karbamoiloksi t�revleri ve antibakteriyel olarak kullan�m�. |
TR199801935T2 (xx) * | 1996-03-28 | 1999-03-22 | Glaxo Group Limited | N�trofil elastaz inhibit�rleri olarak pirolopirolon t�revleri. |
-
1997
- 1997-09-09 GB GBGB9719187.8A patent/GB9719187D0/en not_active Ceased
-
1998
- 1998-09-07 MA MA25244A patent/MA26544A1/fr unknown
- 1998-09-07 EP EP98948905A patent/EP1019406A1/en not_active Withdrawn
- 1998-09-07 PL PL98339186A patent/PL339186A1/xx not_active Application Discontinuation
- 1998-09-07 TR TR2000/01026T patent/TR200001026T2/xx unknown
- 1998-09-07 AP APAP/P/2000/001760A patent/AP2000001760A0/en unknown
- 1998-09-07 WO PCT/EP1998/005604 patent/WO1999012931A1/en not_active Application Discontinuation
- 1998-09-07 ZA ZA9808162A patent/ZA988162B/xx unknown
- 1998-09-07 EA EA200000205A patent/EA200000205A1/ru unknown
- 1998-09-07 IL IL13493598A patent/IL134935A0/xx unknown
- 1998-09-07 CN CN98810967A patent/CN1278821A/zh active Pending
- 1998-09-07 BR BR9811651-7A patent/BR9811651A/pt not_active Application Discontinuation
- 1998-09-07 EE EEP200000137A patent/EE200000137A/xx unknown
- 1998-09-07 CA CA002303249A patent/CA2303249A1/en not_active Abandoned
- 1998-09-07 US US09/508,326 patent/US6228853B1/en not_active Expired - Fee Related
- 1998-09-07 AU AU95360/98A patent/AU9536098A/en not_active Abandoned
- 1998-09-07 JP JP2000510738A patent/JP2001515902A/ja active Pending
- 1998-09-07 ID IDW20000665A patent/ID24364A/id unknown
- 1998-09-07 SK SK324-2000A patent/SK3242000A3/sk unknown
- 1998-09-07 KR KR1020007002505A patent/KR20010023830A/ko not_active Application Discontinuation
- 1998-09-07 HU HU0003475A patent/HUP0003475A3/hu unknown
-
2000
- 2000-03-03 IS IS5394A patent/IS5394A/is unknown
- 2000-03-08 NO NO20001200A patent/NO20001200L/no not_active Application Discontinuation
- 2000-03-09 HR HR20000136A patent/HRP20000136A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU9536098A (en) | 1999-03-29 |
AP2000001760A0 (en) | 2000-03-31 |
ZA988162B (en) | 2000-03-22 |
KR20010023830A (ko) | 2001-03-26 |
BR9811651A (pt) | 2000-08-08 |
SK3242000A3 (en) | 2001-03-12 |
EP1019406A1 (en) | 2000-07-19 |
NO20001200D0 (no) | 2000-03-08 |
IL134935A0 (en) | 2001-05-20 |
HUP0003475A3 (en) | 2002-01-28 |
EE200000137A (et) | 2001-02-15 |
TR200001026T2 (tr) | 2000-09-21 |
NO20001200L (no) | 2000-05-08 |
JP2001515902A (ja) | 2001-09-25 |
ID24364A (id) | 2000-07-13 |
CA2303249A1 (en) | 1999-03-18 |
CN1278821A (zh) | 2001-01-03 |
US6228853B1 (en) | 2001-05-08 |
HRP20000136A2 (en) | 2000-08-31 |
MA26544A1 (fr) | 2004-12-20 |
IS5394A (is) | 2000-03-03 |
PL339186A1 (en) | 2000-12-04 |
HUP0003475A2 (hu) | 2001-09-28 |
WO1999012931A1 (en) | 1999-03-18 |
GB9719187D0 (en) | 1997-11-12 |
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