EA199900608A1 - Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов - Google Patents

Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов

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Publication number
EA199900608A1
EA199900608A1 EA199900608A EA199900608A EA199900608A1 EA 199900608 A1 EA199900608 A1 EA 199900608A1 EA 199900608 A EA199900608 A EA 199900608A EA 199900608 A EA199900608 A EA 199900608A EA 199900608 A1 EA199900608 A1 EA 199900608A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
radical
general formula
possible substituents
Prior art date
Application number
EA199900608A
Other languages
English (en)
Other versions
EA002114B1 (ru
Inventor
Жан-Доминик Бурза
Алан Коммерсон
Норбер Дере
Патрик Майлие
Фабьенн Суниго-Томсон
Жан-Поль Мартэн
Марк Капе
Мишель Шев
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of EA199900608A1 publication Critical patent/EA199900608A1/ru
Publication of EA002114B1 publication Critical patent/EA002114B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к соединениям общей формулы I, к способу их получения, к фармацевтическим композициям на их основе, а также к их использованию для приготовления медикаментов. В общей формуле IAr обозначает замещенный или конденсированный фенил или полициклический или гетероциклический радикал, R обозначает радикал общей формулы - (CH)-X(CH)-Z в которой Xобозначает простую связь, O, S; m = 0,1; n = 0,1,2; причем радикалы (CH)могут быть замещенными; Z обозначает карбокси-радикал, радикал COOR(R- алкил), CON(R) (R), (R- водород или алкил, R- водород, гидрокси, арилсульфонил, гетероцикл, амино с возможными заместителями, алкокси с возможными заместителями, алкил с возможными заместителями, амино, PO(OR), (R- водород или алкил), радикал NH-CO-T (T - или алкил с возможными заместителями), или же радикалRи R- водород или галоген или алкил, алкокси с возможными заместителями, алкилтио, алкоксикарбонил или Rи Rв орто-положении один к другому образуют гетероцикл с 1 или 2 гетероатомами, который может иметь заместители, Rи R– водород, или галоген, или алкил, алкенил, алкокси, алкилтио, карбокси или алкоксикарбонил, R- водород, алкил, алкилтио, X = O, или S, или NH, -CO-, метилен, винилдиил, алкен-1,1-диил или циклоалкан-1,1-диил, и Y = O или S, в рацемической форме или в форме их оптических изомеров, а также солей соединений общей формулы I. Соединения общей формулы I являются ингибиторами фарнезилтрансферазы, которые обладают замечательными противоопухолевыми и антилейкемическими свойствами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900608A 1996-12-30 1997-12-23 Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов EA002114B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9616206A FR2757855B1 (fr) 1996-12-30 1996-12-30 Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/002407 WO1998029390A1 (fr) 1996-12-30 1997-12-23 Inhibiteurs de farnesyle transferase

Publications (2)

Publication Number Publication Date
EA199900608A1 true EA199900608A1 (ru) 2000-02-28
EA002114B1 EA002114B1 (ru) 2001-12-24

Family

ID=9499293

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900608A EA002114B1 (ru) 1996-12-30 1997-12-23 Новые ингибиторы фарнезилтрансферазы, способы их получения, содержащие их фармацевтические композиции и их применение для получения медикаментов

Country Status (32)

Country Link
EP (1) EP0948483B1 (ru)
JP (1) JP2001509147A (ru)
KR (1) KR20000062391A (ru)
AR (1) AR008950A1 (ru)
AT (1) ATE214367T1 (ru)
AU (1) AU741921B2 (ru)
BR (1) BR9714498A (ru)
CA (1) CA2275943A1 (ru)
CO (1) CO4920252A1 (ru)
CZ (1) CZ233599A3 (ru)
DE (1) DE69711081T2 (ru)
DK (1) DK0948483T3 (ru)
DZ (1) DZ2389A1 (ru)
EA (1) EA002114B1 (ru)
ES (1) ES2172033T3 (ru)
FR (1) FR2757855B1 (ru)
HU (1) HUP0001747A3 (ru)
ID (1) ID22922A (ru)
IL (1) IL130453A0 (ru)
MA (1) MA26460A1 (ru)
NO (1) NO993225L (ru)
NZ (1) NZ336042A (ru)
PE (1) PE28199A1 (ru)
PL (1) PL334345A1 (ru)
PT (1) PT948483E (ru)
SK (1) SK88399A3 (ru)
TN (1) TNSN97214A1 (ru)
TR (1) TR199901502T2 (ru)
UY (1) UY24832A1 (ru)
WO (1) WO1998029390A1 (ru)
YU (1) YU30299A (ru)
ZA (1) ZA9711734B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2787327B1 (fr) * 1998-12-21 2003-01-17 Aventis Pharma Sa Compositions contenant des inhibiteurs de farnesyle transferase
FR2796640A1 (fr) * 1999-07-22 2001-01-26 Aventis Pharma Sa Nouveaux inhibiteurs de farnesyle transferase, leur preparation, les compositions pharmaceutiques qui les contiennent et leur utilisation pour la preparation de medicaments
FR2796641B1 (fr) * 1999-07-22 2001-09-21 Aventis Pharma Sa Nouveau procede de preparation de composes benzoperhydroisoindole
FR2845994B1 (fr) * 2002-10-18 2006-05-19 Servier Lab Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0730605A1 (en) * 1993-11-05 1996-09-11 Warner-Lambert Company Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
FR2736641B1 (fr) * 1995-07-10 1997-08-22 Rhone Poulenc Rorer Sa Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
BR9714498A (pt) 2000-03-21
UY24832A1 (es) 2001-08-27
ATE214367T1 (de) 2002-03-15
TNSN97214A1 (fr) 2005-03-15
DE69711081D1 (de) 2002-04-18
SK88399A3 (en) 2000-05-16
NZ336042A (en) 2000-12-22
EP0948483A1 (fr) 1999-10-13
CO4920252A1 (es) 2000-05-29
EP0948483B1 (fr) 2002-03-13
PL334345A1 (en) 2000-02-28
NO993225D0 (no) 1999-06-29
ID22922A (ru) 1999-12-16
WO1998029390A1 (fr) 1998-07-09
DK0948483T3 (da) 2002-07-01
YU30299A (sh) 2002-03-18
HUP0001747A2 (hu) 2000-09-28
FR2757855A1 (fr) 1998-07-03
JP2001509147A (ja) 2001-07-10
KR20000062391A (ko) 2000-10-25
FR2757855B1 (fr) 1999-01-29
ZA9711734B (en) 1998-06-25
HUP0001747A3 (en) 2000-10-30
TR199901502T2 (xx) 1999-09-21
EA002114B1 (ru) 2001-12-24
AR008950A1 (es) 2000-02-23
MA26460A1 (fr) 2004-12-20
ES2172033T3 (es) 2002-09-16
PT948483E (pt) 2002-08-30
AU5669498A (en) 1998-07-31
PE28199A1 (es) 1999-06-05
CZ233599A3 (cs) 1999-09-15
CA2275943A1 (fr) 1998-07-09
DE69711081T2 (de) 2002-08-01
DZ2389A1 (fr) 2002-12-28
AU741921B2 (en) 2001-12-13
NO993225L (no) 1999-08-24
IL130453A0 (en) 2000-06-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU