EA199900433A1 - Производные 2-метоксифенилпиперазина - Google Patents
Производные 2-метоксифенилпиперазинаInfo
- Publication number
- EA199900433A1 EA199900433A1 EA199900433A EA199900433A EA199900433A1 EA 199900433 A1 EA199900433 A1 EA 199900433A1 EA 199900433 A EA199900433 A EA 199900433A EA 199900433 A EA199900433 A EA 199900433A EA 199900433 A1 EA199900433 A1 EA 199900433A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- imidazo
- relates
- formula
- well
- Prior art date
Links
- VNZLQLYBRIOLFZ-UHFFFAOYSA-N 1-(2-methoxyphenyl)piperazine Chemical compound COC1=CC=CC=C1N1CCNCC1 VNZLQLYBRIOLFZ-UHFFFAOYSA-N 0.000 title 1
- -1 2-imidazo [1,2-a] pyridinyl Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- LCCQUAVRRQQTLG-UHFFFAOYSA-N 2,3-dihydroimidazo[2,1-b][1,3]thiazole Chemical compound C1=CN=C2SCCN21 LCCQUAVRRQQTLG-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000027534 Emotional disease Diseases 0.000 abstract 1
- 208000027626 Neurocognitive disease Diseases 0.000 abstract 1
- 206010034719 Personality change Diseases 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретение относится к новым конденсированным гетероциклическим соединениям с кольцевым соединяющим атомом азота формулы (I)где Q - 2-индолизинил, 2-имидазо [1,2-а] пиридинил, 2-имидазо[1,2-а] пиримидинил, 6-(2,3-дигидроимидазо [2,1-b] тиазол)-ил или 6-имидазо [2,1-b] тиазолил; и n - целое число от 2 до 4, а также к их терапевтически полезным солям. Изобретение также относится к фармацевтическим композициям, включающим эти соединения, а также к способу получения указанных соединений и композиций. Новые соединения формулы (I) проявляют, в основном, нейролептическую активность, поэтому изобретение относится также к способу лечения шизофрении, органических умственных расстройств, эмоциональных расстройств, состояния беспокойства и изменения личности.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9603001A HUP9603001A3 (en) | 1996-10-30 | 1996-10-30 | Heterocycle compounds comprising nitrogen, process for producing them and pharmaceutical compositions containing the same |
PCT/HU1997/000069 WO1998018797A1 (en) | 1996-10-30 | 1997-10-22 | 2-methoxyphenylpiperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199900433A1 true EA199900433A1 (ru) | 1999-10-28 |
Family
ID=89994394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199900433A EA199900433A1 (ru) | 1996-10-30 | 1997-10-22 | Производные 2-метоксифенилпиперазина |
Country Status (25)
Country | Link |
---|---|
US (1) | US6103724A (ru) |
EP (1) | EP0935599A1 (ru) |
JP (1) | JP2001503048A (ru) |
KR (1) | KR20000052872A (ru) |
CN (1) | CN1235606A (ru) |
AP (1) | AP9901532A0 (ru) |
AR (1) | AR010260A1 (ru) |
AU (1) | AU4962097A (ru) |
BG (1) | BG103370A (ru) |
BR (1) | BR9712588A (ru) |
CA (1) | CA2269814A1 (ru) |
CZ (1) | CZ132099A3 (ru) |
EA (1) | EA199900433A1 (ru) |
EE (1) | EE9900182A (ru) |
HU (1) | HUP9603001A3 (ru) |
IL (1) | IL129418A0 (ru) |
IS (1) | IS5026A (ru) |
NO (1) | NO992059D0 (ru) |
OA (1) | OA11041A (ru) |
PL (1) | PL333076A1 (ru) |
SK (1) | SK49499A3 (ru) |
TR (1) | TR199900946T2 (ru) |
TW (1) | TW406083B (ru) |
WO (1) | WO1998018797A1 (ru) |
ZA (1) | ZA979617B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
PT1216249E (pt) * | 1999-09-14 | 2004-04-30 | Aventis Pharma Inc | Derivados de etilicos e propilicos insubstituidos de tienoisoxazol-fenoxi uteis como antagonistas d4 |
WO2001019833A1 (en) * | 1999-09-14 | 2001-03-22 | Aventis Pharmaceuticals, Inc. | Thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as d4 antagonists |
US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
WO2001074815A2 (en) | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
TW200811175A (en) * | 2006-06-21 | 2008-03-01 | Nihon Mediphysics Co Ltd | Novel compound with affinity with amyloid |
CA2703649A1 (en) * | 2007-10-24 | 2009-04-30 | Shigeyuki Tanifuji | Novel compound having affinity for amyloid |
CN101903383A (zh) * | 2007-10-26 | 2010-12-01 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物 |
US7985752B2 (en) * | 2008-05-29 | 2011-07-26 | Sk Holdings Co., Ltd. | Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof |
US7964605B2 (en) * | 2008-05-29 | 2011-06-21 | Sk Holdings Co., Ltd. | Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof |
CN106187873B (zh) * | 2016-07-25 | 2019-11-05 | 宜春学院 | 一种芳胺基烷基氧类化合物及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4880824A (en) * | 1987-09-21 | 1989-11-14 | Ortho Pharmaceutical Corporation | Phenyl and benzoyl substituted imidazo-fused heterocyclic calcium channel blockers |
KR100191774B1 (ko) * | 1991-04-22 | 1999-06-15 | 오스카 아끼히꼬 | 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 |
US5486517A (en) * | 1994-05-10 | 1996-01-23 | Warner-Lambert Company | Benzimidazoles and imidazopyridines as central nervous system agents |
US6013654A (en) * | 1997-08-14 | 2000-01-11 | Pharmacia & Upjohn Company | Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases |
-
1996
- 1996-10-30 HU HU9603001A patent/HUP9603001A3/hu unknown
-
1997
- 1997-10-22 PL PL97333076A patent/PL333076A1/xx unknown
- 1997-10-22 AU AU49620/97A patent/AU4962097A/en not_active Abandoned
- 1997-10-22 KR KR1019990703721A patent/KR20000052872A/ko not_active Application Discontinuation
- 1997-10-22 CA CA002269814A patent/CA2269814A1/en not_active Abandoned
- 1997-10-22 EE EEP199900182A patent/EE9900182A/xx unknown
- 1997-10-22 JP JP10520214A patent/JP2001503048A/ja active Pending
- 1997-10-22 CN CN97199313A patent/CN1235606A/zh active Pending
- 1997-10-22 EP EP97912393A patent/EP0935599A1/en not_active Withdrawn
- 1997-10-22 TR TR1999/00946T patent/TR199900946T2/xx unknown
- 1997-10-22 WO PCT/HU1997/000069 patent/WO1998018797A1/en not_active Application Discontinuation
- 1997-10-22 IL IL12941897A patent/IL129418A0/xx unknown
- 1997-10-22 SK SK494-99A patent/SK49499A3/sk unknown
- 1997-10-22 BR BR9712588-1A patent/BR9712588A/pt not_active Application Discontinuation
- 1997-10-22 CZ CZ991320A patent/CZ132099A3/cs unknown
- 1997-10-22 AP APAP/P/1999/001532A patent/AP9901532A0/en unknown
- 1997-10-22 US US09/284,313 patent/US6103724A/en not_active Expired - Fee Related
- 1997-10-22 EA EA199900433A patent/EA199900433A1/ru unknown
- 1997-10-27 ZA ZA9709617A patent/ZA979617B/xx unknown
- 1997-10-31 AR ARP970105061A patent/AR010260A1/es unknown
- 1997-11-17 TW TW086117150A patent/TW406083B/zh active
-
1999
- 1999-04-15 IS IS5026A patent/IS5026A/is unknown
- 1999-04-29 BG BG103370A patent/BG103370A/bg unknown
- 1999-04-29 NO NO992059A patent/NO992059D0/no not_active Application Discontinuation
- 1999-04-30 OA OA9900092A patent/OA11041A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2269814A1 (en) | 1998-05-07 |
JP2001503048A (ja) | 2001-03-06 |
TR199900946T2 (xx) | 1999-07-21 |
HUP9603001A3 (en) | 1999-07-28 |
AU4962097A (en) | 1998-05-22 |
BG103370A (bg) | 2000-05-31 |
CZ132099A3 (cs) | 1999-08-11 |
CN1235606A (zh) | 1999-11-17 |
IS5026A (is) | 1999-04-15 |
OA11041A (en) | 2003-03-07 |
KR20000052872A (ko) | 2000-08-25 |
PL333076A1 (en) | 1999-11-08 |
EP0935599A1 (en) | 1999-08-18 |
HU9603001D0 (en) | 1996-12-30 |
ZA979617B (en) | 1998-05-21 |
BR9712588A (pt) | 1999-10-26 |
SK49499A3 (en) | 2000-03-13 |
HUP9603001A2 (hu) | 1998-07-28 |
WO1998018797A1 (en) | 1998-05-07 |
NO992059L (no) | 1999-04-29 |
AR010260A1 (es) | 2000-06-07 |
AP9901532A0 (en) | 1999-06-30 |
EE9900182A (et) | 1999-12-15 |
IL129418A0 (en) | 2000-02-17 |
TW406083B (en) | 2000-09-21 |
US6103724A (en) | 2000-08-15 |
NO992059D0 (no) | 1999-04-29 |
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