EA199900330A1 - Способ получения бензотиофенов - Google Patents

Способ получения бензотиофенов

Info

Publication number
EA199900330A1
EA199900330A1 EA199900330A EA199900330A EA199900330A1 EA 199900330 A1 EA199900330 A1 EA 199900330A1 EA 199900330 A EA199900330 A EA 199900330A EA 199900330 A EA199900330 A EA 199900330A EA 199900330 A1 EA199900330 A1 EA 199900330A1
Authority
EA
Eurasian Patent Office
Prior art keywords
benzotiophenes
obtaining
provides
cation exchange
improved method
Prior art date
Application number
EA199900330A
Other languages
English (en)
Other versions
EA001914B1 (ru
Inventor
Джеффри Т. Викензи
Тони Й. Занг
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA199900330A1 publication Critical patent/EA199900330A1/ru
Publication of EA001914B1 publication Critical patent/EA001914B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

Данное изобретение обеспечивает улучшенный способ получения бензотиофенов с использованием катионообменных смол.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900330A 1996-09-25 1997-09-19 Способ получения бензотиофенов EA001914B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2669596P 1996-09-25 1996-09-25
PCT/US1997/016683 WO1998013363A1 (en) 1996-09-25 1997-09-19 Process for the synthesis of benzothiophenes

Publications (2)

Publication Number Publication Date
EA199900330A1 true EA199900330A1 (ru) 2000-06-26
EA001914B1 EA001914B1 (ru) 2001-10-22

Family

ID=21833302

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900330A EA001914B1 (ru) 1996-09-25 1997-09-19 Способ получения бензотиофенов

Country Status (31)

Country Link
US (1) US5977383A (ru)
EP (1) EP0832889B1 (ru)
JP (1) JP2001501208A (ru)
KR (1) KR20000048539A (ru)
CN (1) CN1088704C (ru)
AR (1) AR013321A1 (ru)
AT (1) ATE318805T1 (ru)
AU (1) AU718919B2 (ru)
BR (1) BR9712844A (ru)
CA (1) CA2266617A1 (ru)
CO (1) CO4900043A1 (ru)
CZ (1) CZ92899A3 (ru)
DE (1) DE69735339T2 (ru)
EA (1) EA001914B1 (ru)
EG (1) EG21037A (ru)
ES (1) ES2257761T3 (ru)
HU (1) HUP9904228A3 (ru)
ID (1) ID21349A (ru)
IL (1) IL129001A (ru)
IN (1) IN183239B (ru)
MY (1) MY118009A (ru)
NO (1) NO991193L (ru)
NZ (1) NZ334591A (ru)
PE (1) PE2699A1 (ru)
PL (1) PL332208A1 (ru)
TR (1) TR199900672T2 (ru)
TW (1) TW472053B (ru)
UA (1) UA62938C2 (ru)
WO (1) WO1998013363A1 (ru)
YU (1) YU15399A (ru)
ZA (1) ZA978372B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921827B2 (en) * 2000-11-27 2005-07-26 Eli Lilly And Company Process for preparing 3-aryl-benzo{b} thiophenes

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300575B (de) * 1965-05-21 1969-08-07 Bristol Myers Co Benzo[b]thiophene
US3394125A (en) * 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
AT364852B (de) * 1977-11-05 1981-11-25 Thomae Gmbh Dr K Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
IL65378A (en) * 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
US4544746A (en) * 1982-05-17 1985-10-01 Ciba-Geigy Corporation Process for preparing 2-anilinoacridone
KR890701591A (ko) * 1987-09-25 1989-12-21 베르너 발데그 4-(트리알킬벤질)-피페라지닐 화합물의 디아실 유도체
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
DE4204969A1 (de) * 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes

Also Published As

Publication number Publication date
US5977383A (en) 1999-11-02
HUP9904228A2 (hu) 2001-05-28
IL129001A0 (en) 2000-02-17
TW472053B (en) 2002-01-11
TR199900672T2 (xx) 1999-06-21
KR20000048539A (ko) 2000-07-25
IN183239B (ru) 1999-10-09
AU718919B2 (en) 2000-04-20
NO991193D0 (no) 1999-03-11
YU15399A (sh) 2001-07-10
DE69735339D1 (de) 2006-04-27
MY118009A (en) 2004-08-30
ES2257761T3 (es) 2006-08-01
CA2266617A1 (en) 1998-04-02
ID21349A (id) 1999-05-27
BR9712844A (pt) 1999-11-16
EP0832889B1 (en) 2006-03-01
EG21037A (en) 2000-09-30
IL129001A (en) 2003-06-24
DE69735339T2 (de) 2006-10-12
AR013321A1 (es) 2000-12-27
CN1230957A (zh) 1999-10-06
PL332208A1 (en) 1999-08-30
EP0832889A1 (en) 1998-04-01
ZA978372B (en) 1999-03-17
HUP9904228A3 (en) 2001-06-28
NZ334591A (en) 2000-07-28
PE2699A1 (es) 1999-02-04
CO4900043A1 (es) 2000-03-27
JP2001501208A (ja) 2001-01-30
UA62938C2 (en) 2004-01-15
CN1088704C (zh) 2002-08-07
NO991193L (no) 1999-03-25
ATE318805T1 (de) 2006-03-15
EA001914B1 (ru) 2001-10-22
AU4356197A (en) 1998-04-17
CZ92899A3 (cs) 1999-09-15
WO1998013363A1 (en) 1998-04-02

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU