EA199700259A1 - Безводные кристаллы - Google Patents

Безводные кристаллы

Info

Publication number
EA199700259A1
EA199700259A1 EA199700259A EA199700259A EA199700259A1 EA 199700259 A1 EA199700259 A1 EA 199700259A1 EA 199700259 A EA199700259 A EA 199700259A EA 199700259 A EA199700259 A EA 199700259A EA 199700259 A1 EA199700259 A1 EA 199700259A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
crystal
compound
active ingredient
anhydrous crystal
Prior art date
Application number
EA199700259A
Other languages
English (en)
Other versions
EA000301B1 (ru
Inventor
Юкио Сато
Хироаки Китаока
Тацуя Терада
Макото Оно
Original Assignee
Дайити Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайити Фармасьютикал Ко., Лтд. filed Critical Дайити Фармасьютикал Ко., Лтд.
Publication of EA199700259A1 publication Critical patent/EA199700259A1/ru
Publication of EA000301B1 publication Critical patent/EA000301B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

В настоящем изобретении предложен безводный кристалл соединения, представленного формулой R-CHCONH-R, где Rпредставляет замещенную или незамещенную пиридильную группу или замещенную или незамещенную фенильную группу и Rпредставляет замещенную или незамещенную 2-оксо-1-пирролидинильную группу; по существу не обладающий гигроскопичностью. Безводный кристалл получают сушкой водосодержащего кристалла указанного соединения при температуре 80°С или выше, при пониженном давлении. Полученный безводный кристалл имеет прирост веса 1% или менее при хранении при относительной влажности 83% при температуре 25°С в течение 30 суток. Безводный кристалл используют для производства лекарственного средства, содержащего соединение указанной выше формулы в качестве активного ингредиента с постоянным содержанием активного ингредиента.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700259A 1995-03-23 1996-03-01 Безводные кристаллы EA000301B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP6423495 1995-03-23
JP9478295 1995-04-20
PCT/JP1996/000485 WO1996029308A1 (fr) 1995-03-23 1996-03-01 Cristaux anhydres

Publications (2)

Publication Number Publication Date
EA199700259A1 true EA199700259A1 (ru) 1998-02-26
EA000301B1 EA000301B1 (ru) 1999-04-29

Family

ID=26405355

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700259A EA000301B1 (ru) 1995-03-23 1996-03-01 Безводные кристаллы

Country Status (16)

Country Link
US (1) US6169108B1 (ru)
EP (1) EP0819676B1 (ru)
KR (1) KR100402554B1 (ru)
CN (1) CN1084734C (ru)
AT (1) ATE224873T1 (ru)
AU (1) AU4843696A (ru)
CA (1) CA2215846A1 (ru)
DE (1) DE69623943T2 (ru)
DK (1) DK0819676T3 (ru)
EA (1) EA000301B1 (ru)
ES (1) ES2184852T3 (ru)
HK (1) HK1008991A1 (ru)
NO (1) NO314933B1 (ru)
PT (1) PT819676E (ru)
TW (1) TW430653B (ru)
WO (1) WO1996029308A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060241144A1 (en) * 2005-04-20 2006-10-26 Albert Cha Method for treating apathy syndrome
CN105512207B (zh) * 2015-11-27 2019-04-09 上海携程商务有限公司 争抢式的数据复制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
IT1141287B (it) * 1979-06-13 1986-10-01 Nattermann A & Cie Ammidi di acidi pirrolidin-(2)-on-(1)-ilalchil-carbossilici,procedimento per la loro preparazione e prodotti medicinali che le contengono
US5461157A (en) * 1992-06-19 1995-10-24 Daiichi Pharmaceutical Co., Ltd. Process for preparing pyrrolidinylacetamide derivatives
JPH0665197A (ja) * 1992-06-19 1994-03-08 Dai Ichi Seiyaku Co Ltd ピロリジニルアセトアミド誘導体の製法

Also Published As

Publication number Publication date
EP0819676B1 (en) 2002-09-25
EA000301B1 (ru) 1999-04-29
KR100402554B1 (ko) 2005-09-02
EP0819676A4 (en) 1998-07-08
ES2184852T3 (es) 2003-04-16
NO314933B1 (no) 2003-06-16
AU4843696A (en) 1996-10-08
ATE224873T1 (de) 2002-10-15
TW430653B (en) 2001-04-21
CN1179149A (zh) 1998-04-15
PT819676E (pt) 2003-01-31
WO1996029308A1 (fr) 1996-09-26
DE69623943T2 (de) 2003-08-07
CA2215846A1 (en) 1996-09-26
DE69623943D1 (de) 2002-10-31
HK1008991A1 (en) 1999-07-30
NO974369D0 (no) 1997-09-22
CN1084734C (zh) 2002-05-15
KR19980703240A (ko) 1998-10-15
DK0819676T3 (da) 2003-01-27
US6169108B1 (en) 2001-01-02
NO974369L (no) 1997-11-24
EP0819676A1 (en) 1998-01-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU