EA021570B1 - Твердые композиции для лечения инфекции hcv (варианты) - Google Patents

Твердые композиции для лечения инфекции hcv (варианты) Download PDF

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Publication number
EA021570B1
EA021570B1 EA201290892A EA201290892A EA021570B1 EA 021570 B1 EA021570 B1 EA 021570B1 EA 201290892 A EA201290892 A EA 201290892A EA 201290892 A EA201290892 A EA 201290892A EA 021570 B1 EA021570 B1 EA 021570B1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutically acceptable
surfactant
solid
solid dispersion
composition
Prior art date
Application number
EA201290892A
Other languages
English (en)
Russian (ru)
Other versions
EA201290892A1 (ru
Inventor
Бернд ЛИПОЛЬД
Карин Розенблатт
Петер ХЕЛИГ
Раджив Гокхале
Лина Прасад
Джонатан Миллер
Эрик А. Шмитт
Джон Б. Моррис
Original Assignee
Эббви Бахамаз Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эббви Бахамаз Лтд. filed Critical Эббви Бахамаз Лтд.
Publication of EA201290892A1 publication Critical patent/EA201290892A1/ru
Publication of EA021570B1 publication Critical patent/EA021570B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)
EA201290892A 2010-03-10 2011-03-08 Твердые композиции для лечения инфекции hcv (варианты) EA021570B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33996410P 2010-03-10 2010-03-10
PCT/US2011/027511 WO2011112558A2 (en) 2010-03-10 2011-03-08 Solid compositions

Publications (2)

Publication Number Publication Date
EA201290892A1 EA201290892A1 (ru) 2013-03-29
EA021570B1 true EA021570B1 (ru) 2015-07-30

Family

ID=44564075

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290892A EA021570B1 (ru) 2010-03-10 2011-03-08 Твердые композиции для лечения инфекции hcv (варианты)

Country Status (27)

Country Link
US (1) US20110312973A1 (es)
EP (1) EP2544689B1 (es)
JP (2) JP5717768B2 (es)
KR (1) KR101579079B1 (es)
CN (2) CN103118681B (es)
AR (1) AR081736A1 (es)
AU (1) AU2011224558B2 (es)
BR (1) BR112012022774A2 (es)
CA (1) CA2792601C (es)
CL (1) CL2012002500A1 (es)
CO (1) CO6640208A2 (es)
DO (1) DOP2012000245A (es)
EA (1) EA021570B1 (es)
EC (1) ECSP12012148A (es)
ES (1) ES2613608T3 (es)
GT (1) GT201200257A (es)
IL (1) IL221833A (es)
MX (1) MX2012010478A (es)
MY (1) MY156888A (es)
NZ (1) NZ602288A (es)
PE (1) PE20130198A1 (es)
SG (1) SG183985A1 (es)
TW (1) TWI490218B (es)
UA (1) UA104517C2 (es)
UY (1) UY33265A (es)
WO (1) WO2011112558A2 (es)
ZA (1) ZA201207093B (es)

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US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
CA2847355A1 (en) * 2011-09-16 2013-03-21 Abbvie Inc. Methods for treating hcv
AU2015100283B4 (en) * 2011-10-21 2015-06-18 Abbvie Ireland Unlimited Company Methods for treating HCV
AU2013201758B2 (en) * 2011-10-21 2014-11-27 Abbvie Ireland Unlimited Company Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
AU2015200715A1 (en) * 2011-10-21 2015-03-05 Abbvie Ireland Unlimited Company Methods for treating HCV
AU2013201532B2 (en) 2011-10-21 2014-10-02 Abbvie Ireland Unlimited Company Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
ES2529144B1 (es) * 2011-10-21 2015-10-26 Abbvie Inc. Combinación de aad para uso en el tratamiento del vhc
CH707029B1 (de) * 2011-10-21 2015-03-13 Abbvie Inc Verfahren zur Behandlung von HCV, umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin, aber nicht Interferon.
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
CA2876496A1 (en) 2012-06-27 2014-01-03 Abbvie Inc. Methods for treating hcv
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
NZ630435A (en) * 2012-07-12 2016-11-25 Abbvie Inc Crystalline forms of an hcv inhibitor
RS62676B1 (sr) 2012-09-11 2021-12-31 Medivation Prostate Therapeutics Llc Formulacije enzalutamida
JP6154474B2 (ja) 2012-10-19 2017-06-28 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070974A1 (en) 2012-11-05 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014137869A1 (en) 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
ES2735355T3 (es) 2013-03-15 2019-12-18 Gilead Sciences Inc Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C
JP2016523924A (ja) 2013-07-02 2016-08-12 アッヴィ・インコーポレイテッド Ｈｃｖの治療方法
WO2015038596A1 (en) 2013-09-11 2015-03-19 Emory University Nucleotide and nucleoside compositions and uses related thereto
US20150141351A1 (en) * 2013-11-18 2015-05-21 AbbVie Deutschland GmbH & Co. KG Solid Pharmaceutical Compositions
US20150175612A1 (en) * 2013-12-04 2015-06-25 Abbvie Inc. Crystal forms
EP3089757A1 (en) * 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
EP3099295A1 (en) 2014-01-28 2016-12-07 Abbvie Inc. Dose adjustment in combination therapy of hepatitis c
JP6831704B2 (ja) * 2014-06-18 2021-02-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 非イオン界面活性剤を含む新規の薬学的組成物
US20160074462A1 (en) 2014-09-11 2016-03-17 Abbvie Inc. Method of Treating HCV
WO2016134058A1 (en) 2015-02-18 2016-08-25 Abbvie Inc. Combinations useful to treat hepatitis c virus
US20160375017A1 (en) 2015-06-26 2016-12-29 Abbvie Inc. Solid Pharmaceutical Compositions for Treating HCV
TWI630922B (zh) * 2015-08-28 2018-08-01 康霈生技股份有限公司 用於減少局部脂肪的醫藥組成物及其用途
US11192914B2 (en) 2016-04-28 2021-12-07 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
EP4137132A1 (en) 2016-09-30 2023-02-22 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
WO2018170235A1 (en) 2017-03-15 2018-09-20 Accera, Inc. Pharmaceutical compositions having high drug loadings of medium chain triglycerides and methods related thereto
US10004719B1 (en) 2017-05-30 2018-06-26 Taigen Biotechnology Co., Ltd. Solid dispersion formulation
IL283450B1 (en) * 2018-11-30 2024-02-01 Chemocentryx Inc Solid solution capsule formulations containing (3S,2R)-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6-methylbenzoyl)-N-(4-methyl-3-(trifluoromethyl)phenyl) Piperidine-3-carboxamide, methods for their preparation and their medical uses
WO2023154171A1 (en) * 2022-02-14 2023-08-17 Purdue Research Foundation Polymer salts for improved drug delivery from amorphous solid dispersions

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US20030195228A1 (en) * 2002-02-07 2003-10-16 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20040229776A1 (en) * 2003-04-02 2004-11-18 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20090269305A1 (en) * 2008-04-15 2009-10-29 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
US20100144608A1 (en) * 2008-09-11 2010-06-10 Yiyin Ku Macrocyclic hepatitis C serine protease inhibitors
US20100168384A1 (en) * 2009-06-30 2010-07-01 Abbott Laboratories Anti-viral compounds

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Patent Citations (5)

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US20030195228A1 (en) * 2002-02-07 2003-10-16 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20040229776A1 (en) * 2003-04-02 2004-11-18 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for hepatitis C viral protease inhibitors
US20090269305A1 (en) * 2008-04-15 2009-10-29 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
US20100144608A1 (en) * 2008-09-11 2010-06-10 Yiyin Ku Macrocyclic hepatitis C serine protease inhibitors
US20100168384A1 (en) * 2009-06-30 2010-07-01 Abbott Laboratories Anti-viral compounds

Also Published As

Publication number Publication date
PE20130198A1 (es) 2013-03-24
IL221833A (en) 2017-01-31
CA2792601A1 (en) 2011-09-15
TW201202239A (en) 2012-01-16
KR101579079B1 (ko) 2015-12-21
CN103118681B (zh) 2015-02-18
CO6640208A2 (es) 2013-03-22
UA104517C2 (uk) 2014-02-10
WO2011112558A2 (en) 2011-09-15
UY33265A (es) 2011-10-31
EP2544689B1 (en) 2017-01-11
BR112012022774A2 (pt) 2017-09-12
SG183985A1 (en) 2012-10-30
AU2011224558B2 (en) 2014-02-27
ES2613608T3 (es) 2017-05-24
AR081736A1 (es) 2012-10-17
CN104771364A (zh) 2015-07-15
JP5890553B2 (ja) 2016-03-22
ZA201207093B (en) 2013-05-29
CN103118681A (zh) 2013-05-22
EP2544689A2 (en) 2013-01-16
JP2013522208A (ja) 2013-06-13
MY156888A (en) 2016-04-15
MX2012010478A (es) 2013-02-01
TWI490218B (zh) 2015-07-01
CA2792601C (en) 2015-09-29
US20110312973A1 (en) 2011-12-22
DOP2012000245A (es) 2013-02-15
WO2011112558A3 (en) 2012-01-05
EA201290892A1 (ru) 2013-03-29
JP2015145387A (ja) 2015-08-13
KR20130048210A (ko) 2013-05-09
CL2012002500A1 (es) 2012-12-07
EP2544689A4 (en) 2014-04-02
CN104771364B (zh) 2018-05-25
JP5717768B2 (ja) 2015-05-13
ECSP12012148A (es) 2012-10-30
NZ602288A (en) 2014-02-28
AU2011224558A1 (en) 2012-09-27
GT201200257A (es) 2014-09-26

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